Effects of des-aspartate-angiotensin I on the expression of angiotensin AT1 and AT2 receptors in ventricles of hypertrophic rat hearts

Regulatory Peptides

Volumn 117, Issue 3, 2004, Pages 207-212

  Chen, W S ^a   Sim, M K ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Angiotensin AT1 receptors; Angiotensin AT2 receptors; Cardiac hypertrophy; Des aspartate angiotensin I; Rats; RT PCR; Western blotting

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN DERIVATIVE; ANGIOTENSIN I [DEASPARTIC ACID]; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA COARCTATION; ARTICLE; BINDING ASSAY; CLINICAL PROTOCOL; CONTROLLED STUDY; DESENSITIZATION; DRUG BINDING SITE; DRUG EFFECT; DRUG MEGADOSE; HEART VENTRICLE HYPERTROPHY; INTERNALIZATION; LIGAND BINDING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHAM FEEDING; SPECIES COMPARISON; WESTERN BLOTTING;

EID: 1642430822     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2003.10.017     Document Type: Article

References (19)

1. Blair-West J.R., Coghan J.P., Denton D.A., Funder J.W., Scoggins B.A., Wright R.D. The effect of the heptapeptide (2-8) and hexapeptide (3-8) fragments of angiotensin II on aldosterone secretion. J. Clin. Endocrinol. Metab. 32:1971;575-578.
2. Sim M.K., Min L. Effects of des-aspartate-angiotensin I on experimentally induced cardiac hypertrophy in rats. Int. J. Cardiol. 63:1998;223-227.
3. Min L., Sim M.K., Xu X.G. Effects of des-aspartate-angiotensin I on angiotensin II-induced incorporation of phenylalanine and thymidine in cultured rat cardiomyocetes and aortic smooth muscle cells. Regul. Pept. 95:2000;93-97.
4. Sim M.K., Soh K.S. Effects of des-Asp-angiotensin I on the electrical-stimulated contraction of the rabbit pulmonary artery. Eur. J. Pharmacol. 285:1995;215-219.
5. Sim M.K., Chai S.K. Subtypes of losartan-sensitive angiotensin receptor in the rabbit pulmonary artery. Br. J. Pharmacol. 117:1996;1504-1506.
6. Gasparo M.D., Catt K.J., Inagami T., Wright J.W., Unger T.H. International union of pharmacology: XXIII. The angiotensin II receptors. Pharmacol. Rev. 52:2000;415-472.
7. Horiuch M., Akishita M., Dzau V.J. Recent progress in angiotensin II type 2 receptor research in the cardiovascular system. Hypertension. 33:1999;613-621.
8. Everett A.D., McReddie A.F., Fisher A., Gomez R.A. Angiotensin receptor regulates cardiac hypertrophy and transforming growth factor-β1 expression. Hypertension. 23:1994;587-592.
9. Fujii N., Tanaka M., Ohnishi J., Yukawa K., Takimoto E., Shimada S.et al. Alteration of angiotensin II receptor contents in hypertrophied hearts. Biochem. Biophys. Res. Commun. 212:1995;326-333.
10. Suzuki J., Matsubara H., Urakami M., Inada M. Rat angiotensin II (type 1A) receptor mRNA regulation and subtype expression in myocardial growth and hypertrophy. Circ. Res. 73:1993;439-447.
11. Wolf K., Della B.R., Bruckschlegel G., Schunkert H., Riegger G.A., Kurtz A. Angiotensin II receptor gene expression in hypertrophied left ventricles of rat hearts. J. Hypertens. 14:1996;349-354.
12. Iwai N., Shimoike H., Kinoshita M. Cardiac rennin-angiotensin system in the hypertrophied heart. Circulation. 92:1995;2690-2696.
13. 2-receptor subtypes in hypertrophied rat hearts. Am. J. Physiol. 267:1994;H844-H852.
14. Chen W.S., Sim M.K., Go M.L. Structure-activity and structure-binding studies of des-Asp1-angiotensin I analogues on the rabbit pulmonary artery. Regul. Pept. 106:2002;39-46.
15. Sim M.K., Manjeet S. Properties of muscarinic receptors mediating second messenger responses in the rabbit aorta. Eur. J. Pharmacol. 189:1990;399-404.
16. 1 angiotensin receptor internalization. Regul. Pept. 91:2000;29-44.
17. Hein L.et al. Intracellular trafficking of angiotensin II and its AT1 and AT2 receptor: Evidence for selective sorting of receptor and ligand. Mol. Endocrinol. 11:1997;1266-1277.
18. 2 receptor: fact, fancy and fantasy. Regul. Pept. 81:1999;11-24.
19. Sangaralingham S.J., Pak B.J., Tse M.Y., Angelis E., Adam M.A., Smallegange C.et al. Expression of the translational repressor NAT1 in experimental models of cardiac hypertrophy. Mol. Cell. Biochem. 245:2003;183-190.