A physiologically based pharmacokinetic (PB/PK) model for multiple exposure routes of soman in multiple species

Archives of Toxicology

Volumn 80, Issue 11, 2006, Pages 719-731

  Sweeney, Richard E ^a   Langenberg, Jan P ^b   Maxwell, Donald M ^c  

^a RESECO Research Engineering Consultants   (United States)

^b TNO   (Netherlands)

^c US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; CARBOXYLESTERASE; ENZYME; SOMAN;

ADIPOSE TISSUE; ALLOMETRY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL BLOOD; ARTICLE; BLOOD FLOW VELOCITY; BLOOD LEVEL; BODY WEIGHT; BREATHING RATE; COMPUTER LANGUAGE; COMPUTER SIMULATION; CONTROLLED STUDY; EXPOSURE; GUINEA PIG; IN VITRO STUDY; KIDNEY PERFUSION; LD 50; LIVER PERFUSION; LUNG PERFUSION; MALE; MARMOSET; METABOLISM; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; PROVOCATION TEST; RAT; REGRESSION ANALYSIS; SENSITIVITY ANALYSIS; STEREOISOMERISM; TIDAL VOLUME; TISSUE LEVEL; TOXICOKINETICS; VENOUS BLOOD;

ADMINISTRATION, INHALATION; ANIMALS; CALLITHRIX; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; COMPUTER SIMULATION; GUINEA PIGS; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; MALE; MODELS, BIOLOGICAL; RATS; RATS, WISTAR; SOMAN;

ANIMALIA; CAVIA PORCELLUS; MARMOSETS;

EID: 33751435330     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-006-0114-0     Document Type: Article

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