Effect of ketogenic diet on hippocampus mossy fiber sprouting and GluR5 expression in kainic acid induced rat model

Chinese Medical Journal

Volumn 119, Issue 22, 2006, Pages 1925-1929

  Xu, Xiang Ping ^a   Sun, Ruo Peng ^a   Jin, Rui Feng ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Epilepsy; Glutamate receptor; Kainic acid; Ketogenic diet; Mossy fiber sprouting

Indexed keywords

3 HYDROXYBUTYRIC ACID; GLUTAMATE RECEPTOR 5; KAINIC ACID; MESSENGER RNA;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; EPILEPSY; GENE EXPRESSION; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HISTOPATHOLOGY; KETOGENIC DIET; MALE; MOSSY FIBER; NERVE SPROUTING; NISSL STAINING; NONHUMAN; PROTEIN EXPRESSION; RAT; RAT STRAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 33751433899     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200611020-00013     Document Type: Article

References (18)

1. Muller-Schwarze AB, Tandon P, Liu Z, Yang YL, Holmes GL, Stafstrom CE. Ketogenic diet reduces spontaneous seizures and mossy fiber sprouting in the kainic acid model. Neuroreport 1999; 10: 1517-1522.
2. Holmes GL, Sarkisian M, Ben-Ari Y, Chevassus-Au-Louis N. Mossy fiber sprouting after recurrent seizures during early development in rats. J Comp Neurol 1999; 404: 537-553.
3. Behr J, Gebhardt C, Heinemann U, Mody I. Kindling enhances kainite receptor-mediated depression of GABAergic inhibition in rat granule cells. Eur J Neurosci 2002; 16: 861-867.
4. 3 region of the hippocampus. J Neurosci 2000; 20: 8269-8278.
5. Ziegler DR, Araujo E, Rotta LN, Perry ML, Goncalves CA. A ketogenic diet increases protein phosphorylation in brain slices of rats. J Nutr 2002; 132: 483-487.
6. Lefevre F, Aronson N. Ketogenic diet for the treatment of refractory epilepsy in children: a systematic review of efficacy. Pediatrics 2000; 105: e46.
7. Bough KJ, Valiyil R, Han FT, Eagles DA. Seizure resistance is dependent upon age and calorie restriction in rats fed a ketogenic diet. Epilepsy Res 1999; 35: 21-28.
8. Sutula T, He XX, Cavazos J, Scott G. Synaptic reorganization in the hippocampus induced by abnormal functional activity. Science 1988; 239: 1147-1150.
9. McNamara JO. Emerging insights into the genesis of epilepsy. Nature 1999; 399: a15-21.
10. Zhao Q, Stafstrom CE, Fu DD, Hu Y, Holmes GL. Detrimental effects of the ketogenic diet on cognitive function in rats. Pediatr Res 2004; 55: 498-506.
11. Borowicz KK, Zadrozniak M, Czuczwar SJ. Low-affinity kainite receptor-mediated events reduce the protective activity of phenobarbital and diphenylhydantoin against maximal electroshock in mice. Neuropharmacology 2002; 43:1082-1086.
12. 7 mRNA and protein expression in rat hippocampus. Epilepsia 2005; 46: 616-623.
13. Mathern GW, Pretorius JK, Kornblum HI, Mendoza D, Lozada A, Leite JP, et al. Altered hippocampal kainate-receptor mRNA levels in temporal lobe epilepsy patients. Neurobiol Dis 1998; 5: 151-176.
14. Noh HS, Kin YS, Lee HP, Chung KM, Kim DW, Kang SS, et al. The protective effect of a ketogenic diet on kainic acid-induced hippocampal cell death in the male ICR mice. Epilepsy Res 2003; 53: 119-128.
15. 6 kainate receptor subunits coexist in hippocampus neurons and coassemble to form functional receptors. J Neurosci 2000; 20:196-205.
16. Huettner JE. Kainate receptors and synaptic transmission. Prog Neurobiol 2003; 70: 387-407.
17. Ben-Ari Y, Cossart R. Kainate, a double agent that generates seizures: two decades of progress. Trends Neurosci 2000; 23: 580-587.
18. 5 agonist of kainate receptors. J Neurophysiol 2002; 88: 523-527.