Olfactory Mucosal Necrosis in Male CD Rats Following Acute Inhalation Exposure to Hydrogen Sulfide: ReversibilitY and the Possible Role of Regional Metabolism

Toxicologic Pathology

Volumn 30, Issue 2, 2002, Pages 200-208

  Brenneman, Karrie A ^a   Meleason, David F ^a   Sar, Madhabananda ^a   Marshall, Marianne W ^a   James, R Arden ^a   Gross, Elizabeth A ^a   Martin, Joseph T ^a   Dorman, David C ^a  

^a CIIT Centers for Health Research   (United Kingdom)

Author keywords

annexin I; cytochrome oxidase; immunohistochemistry; microvillar cells; mitochondrial swelling; Nasal pathology; olfactory epithelial regeneration; olfactory marker protein

Indexed keywords

HYDROGEN SULFIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL REGENERATION; CONTROLLED STUDY; ETHMOID SINUS; EXPOSURE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INHALATION; MALE; METABOLISM; MITOCHONDRION SWELLING; NONHUMAN; NOSE INJURY; OLFACTORY EPITHELIUM; OLFACTORY NERVE; PRIORITY JOURNAL; RAT;

ADMINISTRATION, INHALATION; ANIMALS; ELECTRON TRANSPORT COMPLEX IV; HYDROGEN SULFIDE; MALE; MOUTH MUCOSA; NECROSIS; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; RODENTIA;

EID: 0036220815     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/019262302753559533     Document Type: Article

References (30)

1. Agency for Toxic Substances and Disease Registry (ATSDR) (1999). Toxicological Profile for Hydrogen Sulfide, US Department of Commerce, Springfield, VA.
2. Boorman GA, Morgan KT, Uriah LC (1990). Nose, larynx, and trachea. In: Pathology of the Fischer Rat, Boorman GA, Eustis SL, Elwell MR, Montgomery CA Jr, MacKenzie WF (eds). Academic Press, Inc, San Diego, p 321.
3. Brenneman KA, James RA, Gross EA, Dorman DC (2000). Olfactory neuronal loss following subchronic inhalation exposure to low levels of hydrogen sulfide in adult male CD rats. Toxicol Pathol 28: 326-333.
4. Buckley LA, Morgan KT, Swenberg JA, James RA, Hamm Jr JE, Barrow CS (1985). The toxicity of dimethylamine in F-344 rats and B6C3F1 mice following a 1 year inhalation exposure. Fundam Appl Toxicol 5: 341-352.
5. Carr VM, Farbman AI, Colletti LM, Morgan JI (1991). Identification of a new nonneurona l cell type in the rat olfactory epithelium. Neuroscience 45: 433-449.
6. Cheville NF (1976). Cell Pathology, The Iowa State University Press, Ames, IA, pp 10, 46-47.
7. Harding JW, Getchell TV, Margolis FLF (1978). Deviation of the primary olfactory pathway in mice. V. Long-term effect of intranasal ZnSO4 irrigation on behavior, biochemistry and morphology. Brain Res 140: 271-285.
8. Hastings L., Miller ML, Minnerma DJ, Evans J., Radike M. (1991). Effects of methyl bromide on the rat olfactory system. Chem Senses 16: 43-55.
9. Hirsch AR, Zavala G. (1999). Long term effects on the olfactory system of exposure to hydrogen sulfide. Occup Environ Med 56: 284-287.
10. Jiang XZ, Buckley LA, Morgan KT (1983). Histopathology of toxic responses to chlorine gas in the nasal passages of rats and mice. Toxicol Appl Pharmacol 103: 143-155.
11. Johnson EW, Eller PM, Jafek BW (1993). An immuno-electron microscopic comparison of olfactory marker protein localization in the supranuclear regions of the rat olfactory epithelium and vomeronasal organ neuroepithelium. Acta Otolaryngol 113: 766-771.
12. Keller A., Margolis FL (1975). Immunological studies of the rat olfactory marker protein. J Neurochem 24: 1101-1106.
13. Khan AA, Schuler MM, Prior MG, Yong S., Coppock RW, Florence LZ, Lillie LE (1990). Effects of hydrogen sulfide exposure on lung mitochondrial respiratory chain enzymes in rats. Toxicol Appl Pharmacol 103: 482-490.
14. Kimbell JS, Godo MN, Gross EA, Joyner DR, Richardson RB, Morgan KT (1997). Computer simulation of inspiratory airflow in all regions of the F344 rat nasal passages. Toxicol Appl Pharmacol 145: 388-398.
15. Lopez A., Prior M., Yong S., Lillie L., Lefebvre M. (1988). Nasal lesions in rats exposed to hydrogen sulfide for four hours. Am J Vet Res 49: 1107-1111.
16. Méryl S., Gross EA, Joyner DR, Godo M., Morgan KT (1994). Nasal diagrams: A tool for recording the distribution of nasal lesions inrats and mice. Toxicol Pathol 22: 353-372.
17. Miller ML, Andringa A., Evans JE, Hastings L. (1995). Microvillar cells of the olfactory epithelium: Morphology and regeneration following exposure to toxic compounds. Brain Res 669: 1-9.
18. Moran DT, Carter Rowley J. III, Jafek BW (1982). Electron microscopy of human olfactory epithelium reveals a new cell type: The microvillar cell. Brain Res 253: 39-46.
19. Morgan KT (1991). Approaches to the identification and recording of nasal lesions in toxicology studies. Toxicol Pathol 19: 337-351.
20. Morgan KT, Monticello TM (1990). Airflow, gas deposition, and lesion distribution in the nasal passages. Environ Health Perspect 85: 209-218.
21. National Research Council (1996). Guide for the Care and Use of Laboratory Animals, National Academic Press, Washington, DC, p 125.
22. Nicholls, P. (1975). The effect of sulphide on cytochrome aa3 isosteric and allosteric shifts of the reduced α-peak. Biochim Biophys Acta 396: 24-35.
23. Nicholson RA, Roth SH, Zhang A., Zheng J., Brookes J., Skrajny B., Bennington R. (1998). Inhibition of respiratory and bioenergetic mechanisms by hydrogen sulfide in mammalian brain. J Toxicol Environ Health 54: 491-507.
24. Sar M., Welsch F. (1999). Differential expression of estrogen receptor-β and estrogen receptor-α in the rat ovary. Endocrinology 140: 963-971.
25. Savolainen H., Tenhunen R., Elovaara E., Tossavainen A. (1980). Cumulative biochemical effects of repeated hydrogen sulfide intoxication in mouse brain. Int Arch Occup Environ Health 46: 87-92.
26. Schneider JS, Tobe EH, Mozley PD Jr, Barniskis L., Lidsky TI (1998). Persistent cognitive and motor deficits following acute hydrogen sulfide poisoning. Occup Med (Oxf) 48: 255-260.
27. Struve MF, Brisbois JN, James RA, Marshall MW, Dorman DC (2001). Neurotoxicologica l effects associated with short-term exposure of Sprague-Dawley rats to hydrogen sulfide. Neurotoxicology 22: 375-385.
28. Tvedt B., Skyberg K., Aaserud O., Hebbesland A., Matheisen T. (1991). Brain damage caused by hydrogen sulfide: A follow-up study of six patients. Am J Ind Med 20: 91-101.
29. United States Environmental Protection Agency (US EPA) (1993). Health assessment document for hydrogen sulfide, Office of Research and Development, Research Triangle Park, NC.
30. Wong-Riley MTT (1989). Cytochrome oxidase: An endogenous metabolic marker for neuronal activity. Trends Neurosci 12: 94-101.