Analysis of serum antibody profile against H pylori VacA and CagA antigens in Turkish patients with duodenal ulcer

World Journal of Gastroenterology

Volumn 12, Issue 42, 2006, Pages 6869-6873

  Erzin, Yusuf ^a   Altun, Sibel ^a   Dobrucali, Ahmet ^a   Aslan, Mustafa ^a   Erdamar, Sibel ^a   Dirican, Ahmet ^a   Tuncer, Murat ^a   Kocazeybek, Bekir ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

Author keywords

CagA; Duodenal ulcer; H pylori; VacA; Western blot

Indexed keywords

CAGA PROTEIN; IMMUNOGLOBULIN G ANTIBODY; UREASE; VACUOLATING TOXIN;

ADULT; AGED; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ARTICLE; BACTERIAL VIRULENCE; BACTERIUM CULTURE; CHI SQUARE TEST; CONTROLLED STUDY; DIET RESTRICTION; DUODENUM ULCER; DYSPEPSIA; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GASTROINTESTINAL ENDOSCOPY; HELICOBACTER PYLORI; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; PROSPECTIVE STUDY; STATISTICAL SIGNIFICANCE; STOMACH BIOPSY; TURKEY (REPUBLIC); ULCEROGENESIS; WESTERN BLOTTING;

EID: 33751358593     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v12.i42.6869     Document Type: Article

References (39)

1. Dunn BE, Cohen H, Blaser MJ. Helicobacter pylori. Clin Microbiol Rev 1997; 10: 720-741
2. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Schistosomes, liver flukes and Helicobacter pylori. IARC Monogr Eval Carcinog Risks Hum 1994; 61: 1-241
3. Axon AT. Are all helicobacters equal? Mechanisms of gastroduodenal pathology and their clinical implications. Gut 1999; 45 Suppl 1: 1144
4. Blaser MJ. Role of vacA and the cagA locus of Helicobacter pylori in human disease. Aliment Pharmacol Ther 1996; 10 Suppl 1: 73-77
5. Parsonnet J, Friedman GD, Orentreich N, Vogelman H. Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut 1997; 40: 297-301
6. Blaser MJ, Crabtree JE. CagA and the outcome of Helicobacter pylori infection. Am J Clin Pathol 1996; 106: 565-567
7. Cover TL, Dooley CP, Blaser MJ. Characterization of and human serologic response to proteins in Helicobacter pylori broth culture supernatants with vacuolizing cytotoxin activity. Infect Immun 1990; 58: 603-610
8. Phadnis SH, Ilver D, Janzon L, Normark S, Westblom TU. Pathological significance and molecular characterization of the vacuolating toxin gene of Helicobacter pylori. Infect Immun 1994; 62: 1557-1565
9. Schmitt W, Haas R. Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: structural similarities with the IgA protease type of exported protein. Mol Microbiol 1994; 12: 307-319
10. Ertem D, Harmanci H, Pehlivanoglu E. Helicobacter pylori infection in Turkish preschool and school children: role of socioeconomic factors and breast feeding. Turk J Pediatr 2003; 45: 114-199
11. Us D, Hascelik G. Seroprevalence of Helicobacter pylori infection in an Asymptornatic Turkish population. J Infect 1998; 37: 148-150
12. Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med 2002; 347: 1175-1186
13. Akopyanz N, Bukanov NO, Westblom TU, Kresovich S, Berg DE. DNA diversity among clinical isolates of Helicobacter pylori detected by PCR-based RAPD fingerprinting. Nucleic Acids Res 1992; 20: 5137-5142
14. Fujimoto S, Marshall B, Blaser MJ. PCR-based restriction fragment length polymorphism typing of Helicobacter pylori. J Clin Microbiol 1994; 32: 331-334
15. Cover TL. The vacuolating cytotoxin of Helicobacter pylori. Mol Microbiol 1996; 20: 241-246
16. Atherton JC, Cao P, Peek RM Jr, Tummuru MK, Blaser MJ, Cover TL. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem 1995; 270: 17771-17777
17. Figura. N, Guglielmetti P, Rossolini A, Barberi A, Cusi G, Musmanno RA, Russi M, Quaranta S. Cytotoxin production by Campylobacter pylori strains isolated from patients with peptic ulcers and from patients with chronic gastritis only. J Clin Microbiol 1989; 27: 225-226
18. Fox JG, Correa P, Taylor NS, Thompson N, Fontham E, Janney F, Sobhan M, Ruiz B, Hunter F. High prevalence and persistence of cytotoxin-positive Helicobacter pylori strains in a population with high prevalence of atrophic gastritis. Am J Gastroenterol 1992; 87: 1554-1560
19. Leunk RD. Production of a cytotoxin by Helicobacter pylori. Rev Infect Dis 1991; 13 Suppl 8: S686-S689
20. Cover TL, Dooley CP, Blaser MJ. Characterization of and human serologic response to proteins in Helicobacter pylori broth culture supernatants with vacuolizing cytotoxin activity. Infect Immun 1990; 58: 603-610
21. Tee W, Lambert JR, Dwyer B. Cytotoxin production by Helicobacter pylori from patients with upper gastrointestinal tract diseases. J Clin Microbiol 1995; 33: 1203-1205
22. Tummura MK, Cover TL, Blaser MJ. Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production. Infect Immun 1993; 61: 1799-1809
23. Covacci A, Censini S, Bugnoli M, Petracca. R, Burroni D, Macchia G, Massone A, Papini E, Xiang Z, Figura N. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci USA 1993; 90: 5791-5795
24. Crabtree JE, Taylor JD, Wyatt JI, Heatley RV, Shallcross TM, Tompkins DS, Rathbone BJ. Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology. Lancet 1991; 338: 332-335
25. Oderda G, Figura N, Bayeli PF. Serologic IgG recognition of Helicobacter pylori cytotoxin-associated protein, peptic ulcer and gastroduodenal pathology in childhood. Eur J Gastroenterol Hepatol 1993; 5: 695-699
26. Sozzi M, Valentini M, Figura N, De Paoli P, Tedeschi RM, Gloghini A, Serraino D, Poletti M, Carbone A. Atrophic gastritis and intestinal metaplasia in Helicobacter pyloti infection: the role of CagA status. Am J Gastroenterol 1998; 93: 375-379
27. Cover TL, Glupczynski Y, Lage AP, Burette A, Tummuru. MK, Perez-Perez GI, Blaser MJ. Serologic detection of infection with cagA+ Helicobacter pylori strains. J Clin Microbiol 1995; 33: 1496-1500
28. Crabtree JE, Wyatt JI, Sobala GM, Miller G, Tompkins DS, Primrose JN, Morgan AG. Systemic and mucosal humoral responses to Helicobacter pylori in gastric cancer. Gut 1993; 34: 1339-1343
29. Maeda S, Ogura K, Yoshida H, Kanai F, lkenoue T, Kato N, Shiratori Y, Omata M. Major virulence factors, VacA and CagA, are commonly positive in Helicobacter pylori isolates in Japan. Gut 1998; 42: 338-343
30. Hua J, Zheng PY, Yeoh KG, Ho B. The status of the cagA gene does not predict Helicobacter pylori-associated peptic ulcer disease in Singapore. Microbios 2000; 102: 113-120
31. Yang JC, Wang TH, Wang HJ, Kuo CH, Wang JT, Wang WC. Genetic analysis of the cytotoxin-associated gene and the vacuolating toxin gene in Helicobacter pylori strains isolated from Taiwanese patients. Am J Gastroenterol 1997; 92: 1316-1321
32. Yamaoka Y, Kodama T, Gutierrez O, Kim JG, Kashima. K, Graham DY. Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: studies in four different countries. J Clin Microbiol 1999; 37: 2274-2279
33. Yamaoka Y, Souchek J, Odenbreit S, Haas R, Arnqvist A, Boren T, Kodama T, Osato MS, Gutierrez O, Kim JG, Graham DY. Discrimination between cases of duodenal ulcer and gastritis on the basis of putative virulence factors of Helicobacter pylori. J Clin Microbiol 2002; 40: 2244-2246
34. Butent K, Murat A, Esin A, Fatih K, MMMurat H, Hakan H, Melih K, Mehmet A, Bulent Y, Fatih H. Association of CagA and VacA presence with ulcer and non-ulcer dyspepsia in a Turkish population. World J Gastroenterol 2003; 9: 1580-1583
35. Demirturk L, Ozel AM, Yazgan Y, Solmazgul E, Yildirim S, Gultepe M, Gurbuz AK. CagA status in dyspeptic patients with and without peptic ulcer disease in Turkey: association with histopathologic findings. Helicobacter 2001; 6: 163-168
36. Serin E, YUrnaz U, Kunefeci G, Ozer B, Gumurdulu Y, Guclu M, Kayasekuk F, Boyacioglu S. Serum positive cagA in patients with non-uker dyspepsia and peptic ulcer disease from two centers in different regions of Turkey. World J Gastroenterol 2003; 9: 833-835
37. Abasiyanik MF, Sander E, Salih BA. Helicobacter pylori anti-CagA antibodies: prevalence in symptomatic and asymptornatic subjects in Turkey. Can J Gastroenterol 2002; 16: 527-532
38. Saribasak H, Salih BA, Yamaoka Y, Sander E. Analysis of Helicobacter pylori genotypes and correlation with clinical outcome in Turkey. J Clin Microbiol 2004; 42:1648-1651
39. Graham DY, Yamaoka Y. Disease-specific Helicobacter pylori virulence factors: the unfulfilled promise. Helicobacter 2000; 5 Suppl 1: S3-S9; discussion S27-S31