A comparative study of neovascularisation in atherosclerotic plaques using CD31, CD105 and TGFβ1

Pathobiology

Volumn 73, Issue 4, 2006, Pages 192-197

  Li, Chenggang ^a   Mollahan, Pamela ^b   Baguneid, Mohamed S ^b   McMahon, Ray F ^b   Kumar, Pat ^c   Walker, Michael G ^b   Freemont, Anthony J ^a   Kumar, Shant ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER ROYAL INFIRMARY   (United Kingdom)

^c MANCHESTER METROPOLITAN UNIVERSITY   (United Kingdom)

Author keywords

Atherosclerosis; CD105; CD31; Neovascularisation; TGF 1

Indexed keywords

ANTIBODY; BIOLOGICAL MARKER; CD31 ANTIGEN; ENDOGLIN; LIPID; TRANSFORMING GROWTH FACTOR BETA1;

ARTERY; ARTICLE; ATHEROMA; ATHEROSCLEROTIC PLAQUE; CAROTID ENDARTERECTOMY; COMPARATIVE STUDY; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOLOGY; INTIMA; MAJOR CLINICAL STUDY; MICROVASCULATURE; NEOVASCULARIZATION (PATHOLOGY); PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; STAINING; TISSUE SECTION;

ANTIGENS, CD; ANTIGENS, CD31; ATHEROSCLEROSIS; BIOLOGICAL MARKERS; CAROTID STENOSIS; HUMANS; IMMUNOENZYME TECHNIQUES; NEOVASCULARIZATION, PATHOLOGIC; RECEPTORS, CELL SURFACE; TRANSFORMING GROWTH FACTOR BETA1;

EID: 33751332294     PISSN: 10152008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000096020     Document Type: Article

References (30)

1. Kadar A, Glasz T: Development of atherosclerosis and plaque biology. Cardiovasc Surg 2001;9:109-121.
2. Corti R, Fuster V, Badimon JJ: Pathogenetic concepts of acute coronary syndromes. J Am Coll Cardiol 2003;41(4 suppl S):7S-14S.
3. Barger AC, Beeuwkes R 3rd, Lainey LL, Silverman KJ: Hypothesis: vasa vasorum and neovascularization of human coronary arteries. A possible role in the pathophysiology of atherosclerosis. N Engl J Med 1984;310:175-177.
4. Conway EM: Angiogenesis: a link to thrombosis in athero-thrombotic disease. Pathophysiol Haemost Thromb 2004;33:241-248.
5. Ross JS, Stagliano NE, Donovan MJ, Breitbart RE, Ginsburg GS: Atherosclerosis: a cancer of the blood vessels? Am J Clin Pathol 2001;116:s97-s107.
6. Hayden MR, Tyagi SC: Arteriogenesis: angiogenesis within unstable atherosclerotic plaque - interactions with extracellular matrix. Curr Interv Cardiol Rep 2000;2:218-227.
7. Cicha I, Yilmaz A, Klein M, et al: Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitro. Arterioscler Thromb Vasc Biol 2005;25:1008-1013.
8. Laszik ZG, Zhou XJ, Ferrell GL, Silva FG, Esmon CT: Down-regulation of endothelial expression of endothelial cell protein C receptor and thrombomodulin in coronary atherosclerosis. Am J Pathol 2001;159:797-802.
9. Milei J, Parodi JC, Fernandez-Alonso G, et al: Carotid atherosclerosis. Immunocytochemical analysis of the vascular and cellular composition in endarterectomies. Cardiologia 1996;41:535-542.
10. Zibara K, Chignier E, Covacho C, et al: Modulation of expression of endothelial intercellular adhesion molecule-1, platelet-endothelial cell adhesion molecule-1, and vascular cell adhesion molecule-1 in aortic arch lesions of apolipoprotein E-deficient compared with wild-type mice. Arterioscler Thromb Vasc Biol 2000;20:2288-2296.
11. Duff SE, Li C, Garland JM, Kumar S: CD105 is important for angiogenesis: evidence and potential applications. FASEB J 2003;17:984-992.
12. Fox SB, Harris AL: Histological quantitation of tumour angiogenesis. APMIS 2004;112:413-430.
13. Li C, Gardy R, Seon BK, et al: Both high intratumoral microvessel density determined using CD105 antibody and elevated plasma levels of CD105 in colorectal cancer patients correlate with poor prognosis. Br J Cancer 2003;88:1424-1431.
14. Sharma S, Sharma MC, Sarkar C: Morphology of angiogenesis in human cancer: a conceptual overview, histoprognostic perspective and significance of neoangiogenesis. Histopathology 2005;46:481-489.
15. Kumar S, Ghellal A, Li C, et al: Breast carcinoma: vascular density determined using CD105 antibody correlates with tumor prognosis. Cancer Res 1999;59:856-861.
16. Carr S, Farb A, Pearce WH, Virmani R, Yao JS: Atherosclerotic plaque rupture in symptomatic carotid artery stenosis. J Vasc Surg 1996;23:755-765.
17. de Boer OJ, van der Wal AC, Teeling P, Becker AE: Leucocyte recruitment in rupture prone regions of lipid-rich plaques: a prominent role for neovascularization? Cardiovasc Res 1999;41:443-449.
18. Ferroni P, Basili S, Davi G: Platelet activation, inflammatory mediators and hypercholesterolemia. Curr Vasc Pharmacol 2003;1:157-169.
19. Cook-Mills JM, Deem TL: Active participation of endothelial cells in inflammation. J Leukoc Biol 2005;77:487-495.
20. Bobik A, Agrotis A, Kanellakis P, et al: Distinct patterns of transforming growth factor-beta isoform and receptor expression in human atherosclerotic lesions. Colocalization implicates TGF-beta in fibrofatty lesion development. Circulation 1999;99:2883-2891.
21. Grainger DJ: Transforming growth factor beta and atherosclerosis: so far, so good for the protective cytokine hypothesis. Arterioscler Thromb Vasc Biol 2004;24:399-404.
22. McCaffrey TA: TGF-betas and TGF-beta receptors in atherosclerosis. Cytokine Growth Factor Rev 2000;11:103-114.
23. Lutgens E, Gijbels M, Smook M, et al: Transforming growth factor-beta mediates balance between inflammation and fibrosis during plaque progression. Arterioscler Thromb Vasc Biol 2002;22:975-982.
24. Mallat Z, Gojova A, Marchiol-Fournigault C, et al: Inhibition of transforming growth factor-beta signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice. Circ Res 2001;89:930-934.
25. Pepper MS: Transforming growth factor-beta: vasculogenesis, angiogenesis, and vessel wall integrity. Cytokine Growth Factor Rev 1997;8:21-43.
26. 1 on human vascular endothelial cells. FASEB J 2000;14:55-64.
27. Conley BA, Smith JD, Guerrero-Esteo M, Bernabeu C, Vary CP: Endoglin, a TGF-beta receptor-associated protein, is expressed by smooth muscle cells in human atherosclerotic plaques. Atherosclerosis 2000;153:323-335.
28. Li C, Bethell H, Wilson PB, Bhatnagar D, Walker MG, Kumar S: The significance of CD105, TGF7beta; and CD105/TGFβ complexes in coronary artery disease. Atherosclerosis 2000;152:249-256.
29. Conley BA, Koleva R, Smith JD, et al: Endoglin controls cell migration and composition of focal adhesions: function of the cytosolic domain. J Biol Chem 2004;279:27440-27449.
30. Li C, Guo B, Ding S, et al: TNF alpha downregulates CD105 expression in vascular endothelial cells: a comparative study with TGF beta 1. Anticancer Res 2003;23:1189-1196.