Intrastriatal infusion of the Parkinsonian neurotoxin, MPP+, induces damage of striatal cell nuclei in Sprague-Dawley rats

Journal of Chemical Neuroanatomy

Volumn 32, Issue 2-4, 2006, Pages 90-100

  Banerjee, Rebecca ^a   Sreetama, Sen ^a   Saravanan, Karuppagounder S ^a   Chandra, Goutam ^a   Nath De, Sailendra ^a   Mohanakumar, Kochupurackal P ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

Cholinergic neurons; Distorted and shrunken nuclei; Intrastriatal infusion of MPP+; Non dopaminergic toxicity; Nucleus and nucleolus; Parkinson's disease; Perinuclear nucleolus

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; ACETYLCHOLINESTERASE; ACRIDINE ORANGE; DOPAMINE; DYE; HOE 33342; HYDROLASE; NEUROTOXIN; SODIUM CHLORIDE; TYROSINE HYDROLASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CELL DAMAGE; CELL DENSITY; CELL NUCLEUS MEMBRANE; CELL POPULATION; CHOLINERGIC NERVE CELL; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; ELECTROCHEMISTRY; ENZYMOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFUSION; LATERAL BRAIN VENTRICLE; MALE; MEASUREMENT; NONHUMAN; NUCLEOLUS; PARKINSONISM; PERIKARYON; PRIORITY JOURNAL; RAT; RAT STRAIN; SPINDLE CELL; SUBSTANTIA NIGRA;

1-METHYL-4-PHENYLPYRIDINIUM; ACETYLCHOLINE; ANIMALS; ATROPHY; CELL NUCLEUS; CHOLINERGIC FIBERS; COLORING AGENTS; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HERBICIDES; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; NERVE DEGENERATION; NEURONS; NEUROTOXINS; PARKINSONIAN DISORDERS; RATS; RATS, SPRAGUE-DAWLEY; TYROSINE 3-MONOOXYGENASE;

EID: 33751330408     PISSN: 08910618     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchemneu.2006.05.004     Document Type: Article

References (67)

1. Altar C.A., Heikkila R.E., Manzino L., and Marien M.R. 1-Methyl-4-phenylpyridine (MPP+): regional dopamine neuron uptake, toxicity, and novel rotational behavior following dopamine receptor proliferation. Eur. J. Pharmacol. 131 (1986) 199-209
2. Bezard E., Gross C.E., Fournier M.C., Dovero S., Bloch B., and Jaber M. Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter. Exp. Neurol. 155 (1999) 268-273
3. Bjugstad K.B., Redmond Jr. D.E., Teng Y.D., Elsworth J.D., Roth R.H., Blanchard B.C., Snyder E.Y., and Sladek Jr. J.R. Neural stem cells implanted into MPTP-treated monkeys increase the size of endogenous tyrosine hydroxylase-positive cells found in the striatum: a return to control measures. Cell Transplant. 14 (2005) 183-192
4. + can disrupt the nigrostriatal dopamine system by acting in the terminal area. Neuropharmacology 25 (1986) 939-941
5. Burns R.S., Chiueh C.C., Markey S.P., Ebert M.H., Jacobowitz D.M., and Kopin I.J. A primate model of Parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Natl. Acad. Sci. U.S.A. 80 (1983) 4546-4550
6. + injection into rat substantia nigra causes secondary glial activation but not cell death in the ipsilateral striatum. Neurobiol. Dis. 7 (2000) 343-361
7. +-induced neurodegeneration and glutathione impairment in the nigrostriatal dopaminergic pathway. J. Pineal Res. 32 (2002) 262-269
8. +, a metabolite of MPTP, by brain synaptosomes. Biochem. Biophys. Res. Commun. 128 (1985) 1228-1232
9. Chiueh C.C., Markey S.P., Burns R.S., Johannessen J.N., Pert A., and Kopin I.J. Neurochemical and behavioral effects of systemic and intranigral administration of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the rat. Eur. J. Pharmacol. 100 (1984) 189-194
10. 125I]RT1-55. Brain Res. 690 (1995) 217-224
11. Date I., Felten D.L., and Felten S.Y. Long-term effect of MPTP in the mouse brain in relation to aging: neurochemical and immunocytochemical analysis. Brain Res. 519 (1990) 266-276
12. Davis G.C., Williams A.C., Markey S.P., Ebert M.H., Caine E.D., Reichert C.M., and Kopin I.J. Chronic Parkinsonism secondary to intravenous injection of meperidine analogues. Psychiatry Res. 1 (1979) 249-254
13. + in astrocytic cultures. Toxicol. Appl. Pharmacol. 158 (1999) 296-302
14. +) decreases striatal fructose 2,6-bisphosphate in rats. J. Neurochem. 62 (1994) 1913-1920
15. Espino A., Cutillas B., Tortosa A., Ferrer I., Bartrons R., and Ambrosio S. Chronic effects of single intrastriatal injections of 6-hydroxydopamine or 1-methyl-4-phenylpyridinium studied by microdialysis in freely moving rats. Brain Res. 695 (1995) 151-157
16. +-lesioned rats: a microdialysis study in vivo. Neurochem. Res. 23 (1998) 1217-1223
17. Frim D.M., Uhler T.A., Galpern W.R., Beal M.F., Breakefield X.O., and Isacson O. Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 5104-5108
18. Gainetdinov R.R., Fumagalli F., Jones S.R., and Caron M.G. Dopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter. J. Neurochem. 69 (1997) 1322-1325
19. Ghorayeb I., Fernagut P.O., Hervier L., Labattu B., Bioulac B., and Tison F. A 'single toxin-double lesion' rat model of striatonigral degeneration by intrastriatal 1-methyl-4-phenylpyridinium ion injection: a motor behavioural analysis. Neuroscience 115 (2002) 33-46
20. Hartmann A., Troadec J.D., Hunot S., Kikly K., Faucheux B.A., Mouatt-Prigent A., Ruberg M., Agid Y., and Hirsch E.C. Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis. J. Neurosci. 21 (2001) 2247-2255
21. Haycock J.W. Stimulation-dependent phosphorylation of tyrosine-hydroxylase in rat corpus striatum. Brain Res. Bull. 19 (1987) 619-622
22. Heikkila R.E., Manzino L., Cabbat F.S., and Duvoisin R.C. Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by monoamine oxidase inhibitors. Nature 311 (1984) 467-469
23. +) to rats. Neurosci. Lett. 59 (1985) 135-140
24. Heikkila R.E., Nicklas W.J., Vyas I., and Duvoisin R.C. Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity. Neurosci. Lett. 62 (1985) 389-394
25. Henze C., Hartmann A., Lescot T., Hirsch E.C., and Michel P.P. Proliferation of microglial cells induced by 1-methyl-4-phenylpyridinium in mesencephalic cultures results from an astrocyte-dependent mechanism: role of granulocyte macrophage colony-stimulating factor. J. Neurochem. 95 (2005) 1069-1077
26. Hersch S.M., Yi H., Heilman C.J., Edwards R.H., and Levey A.I. Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra. J. Comp. Neurol. 388 (1997) 211-227
27. Holt D.J., Hersh L.B., and Saper C.B. Cholinergic innervation in the human striatum: a three-compartment model. Neuroscience 74 (1996) 67-87
28. Jasso-Lopez D., and Tapia R. Neurotoxic effect of intranigral injection of 1-methyl-4-phenylpyridinium on GABA-containing neurons and its relation to circling behavior. J. Neurochem. 64 (1995) 794-801
29. + by dopamine neurons explains selectivity of Parkinsonism-inducing neurotoxin, MPTP. Eur. J. Pharmacol. 106 (1984) 455-456
30. Karnovsky M.J., and Roots L. A "direct-coloring" thiocholine method for cholinesterases. J. Histochem. Cytochem. 12 (1964) 219-221
31. Kohutnicka M., Lewandowska E., Kurkowska-Jastrzebska I., Czlonkowski A., and Czlonkowska A. Microglial and astrocytic involvement in a murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Immunopharmacology 39 (1998) 167-180
32. Lam C.S., Korzh V., and Strahle U. Zebrafish embryos are susceptible to the dopaminergic neurotoxin MPTP. Eur. J. Neurosci. 21 (2005) 1758-1762
33. Langston J.W., Ballard P., Tetrud J.W., and Irwin I. Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219 (1983) 979-980
34. 3H]PTT), for dopamine transport sites in rat brain. J. Pharmacol. Exp. Ther. 293 (2000) 686-696
35. Ma T., Cai Z., Wellman S.E., and Ho I.K. A quantitative histochemistry technique for measuring regional distribution of acetylcholinesterase in the brain using digital scanning densitometry. Anal. Biochem. 296 (2001) 18-28
36. Maharaj D.S., Saravanan K.S., Maharaj H., Mohanakumar K.P., and Daya S. Acetaminophen and aspirin inhibit superoxide anion generation and lipid peroxidation, and protect against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats. Neurochem. Int. 44 (2004) 355-360
37. McNaught K.S., and Jenner P. Altered glial function causes neuronal death and increases neuronal susceptibility to 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced toxicity in astrocytic/ventral mesencephalic co-cultures. J. Neurochem. 73 (1999) 2469-2476
38. Mitra N., Mohanakumar K.P., and Ganguly D.K. Dissociation of serotoninergic and dopaminergic components in acute effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Brain Res. Bull. 28 (1992) 355-364
39. Mitra N., Mohanakumar K.P., and Ganguly D.K. Resistance of golden hamster to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: relationship with low levels of regional monoamine oxidase-B. J. Neurochem. 62 (1994) 1906-1912
40. +. Neuroreport 15 (2004) 1039-1044
41. + on the release of serotonin and 5-hydroxyindoleacetic acid from rat striatum in vivo. Eur. J. Pharmacol. 166 (1989) 49-55
42. Mori S., Fujitake J., Kuno S., and Sano Y. Immunohistochemical evaluation of the neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on dopaminergic nigrostriatal neurons of young adult mice using dopamine and tyrosine hydroxylase antibodies. Neurosci. Lett. 90 (1988) 57-62
43. Muralikrishnan D., and Mohanakumar K.P. Neuroprotection by bromocriptine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice. FASEB J. 12 (1998) 905-912
44. Nakamura K., Bindokas V.P., Marks J.D., Wright D.A., Frim D.M., Miller R.J., and Kang U.J. The selective toxicity of 1-methyl-4-phenylpyridinium to dopaminergic neurons: the role of mitochondrial complex I and reactive oxygen species revisited. Mol. Pharmacol. 58 (2000) 271-278
45. Nicklas W.J., Vyas I., and Heikkila R.E. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci. 36 (1985) 2503-2508
46. Palkovits M., and Brownstein M.J. Microdissection of brain areas by punch techniques. In: Cuello A.C. (Ed). Brain Microdissection Techniques (1983), John Wiley & Sons, New York 1-36
47. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates. fourth ed. (1998), Academic Press, San Diego
48. Pickel V.M., Garzon M., and Mengual E. Electron microscopic immunolabeling of transporters and receptors identifies transmitter-specific functional sites envisioned in Cajal's neuron. Prog. Brain Res. 136 (2002) 145-155
49. Pollard H.B., Dhariwal K., Adeyemo O.M., Markey C.J., Caohuy H., Levine M., Markey S., and Youdim M.B. A Parkinsonian syndrome induced in the goldfish by the neurotoxin MPTP. FASEB J. 6 (1992) 3108-3116
50. Przedborski S., and Vila M. The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model a tool to explore the pathogenesis of Parkinson's disease. Ann. N. Y. Acad. Sci. 991 (2003) 189-198
51. Ramsay R.R., and Singer T.P. Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria. J. Biol. Chem. 261 (1986) 7585-7587
52. Ricaurte G.A., Langston J.W., Delanney L.E., Irwin I., Peroutka S.J., and Forno L.S. Fate of nigrostriatal neurons in young mature mice given 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: a neurochemical and morphological reassessment. Brain Res. 376 (1986) 117-124
53. Robinson D.G., Ehlers U., Herken R., Herrmann B., Mayer F., and Schurmann F.W. Methods of Preparation for Electron Microscopy (1987), Springer Verlag, Berlin/Heidelberg
54. Sairam K., Saravanan K.S., Banerjee R., and Mohanakumar K.P. Non-steroidal anti-inflammatory drug sodium salicylate, but not diclofenac or celecoxib, protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats. Brain Res. 966 (2003) 245-252
55. Serra P.A., Sciola L., Delogu M.R., Spano A., Monaco G., Miele E., Rocchitta G., Miele M., Migheli R., and Desole M.S. The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induces apoptosis in mouse nigrostriatal glia. Relevance to nigral neuronal death and striatal neurochemical changes. J. Biol. Chem. 277 (2002) 34451-34461
56. +) nigral toxicity in the rat by prior decortication or MK-801 treatment: a stereological estimate of neuronal loss. Neurobiol. Aging 14 (1993) 295-301
57. Storey E., Hyman B.T., Jenkins B., Brouillet E., Miller J.M., Rosen B.R., and Beal M.F. 1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism. J. Neurochem. 58 (1992) 1975-1978
58. + and MPP+. J. Neural Transm. 74 (1988) 75-86
59. Sundstrom E., Goldstein M., and Jonsson G. Uptake inhibition protects nigro-striatal dopamine neurons from the neurotoxicity of 1-methyl-4-phenylpyridine (MPP+) in mice. Eur. J. Pharmacol. 131 (1986) 289-292
60. Sundstrom E., Fredriksson A., and Archer T. Chronic neurochemical and behavioral changes in MPTP-lesioned C57BL/6 mice: a model for Parkinson's disease. Brain Res. 528 (1990) 181-188
61. Tatton N.A., and Kish S.J. In situ detection of apoptotic nuclei in the substantia nigra pars compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydrophenylpyridine treated mice using terminal deoxynucleotidyl transferase labeling and acridine orange. Neuroscience 77 (1997) 1037-1048
62. +). Neurosci. Lett. 141 (1992) 203-207
63. Tomas-Camardiel M., Sanchez-Hidalgo M.C., Sanchez del Pino M.J., Navarro A., Machado A., and Cano J. Comparative study of the neuroprotective effect of dehydroepiandrosterone and 17beta-estradiol against 1-methyl-4-phenylpyridium toxicity on rat striatum. Neuroscience 109 (2002) 569-584
64. Tsai M.J., and Lee E.H. Nitric oxide donors protect cultured rat astrocytes from 1-methyl-4-phenylpyridinium-induced toxicity. Free Radic. Biol. Med. 24 (1998) 705-713
65. +-induced COX-2 activation and subsequent dopaminergic neurodegeneration. FASEB J. 19 (2005) 1134-1136
66. +: selective vulnerability of cultured mouse astrocytes. Brain Res. 836 (1999) 237-244
67. Zang L.Y., and Misra H.P. Acetylcholinesterase inhibition by 1-methyl-4-phenylpyridinium ion, a bioactivated metabolite of MPTP. Mol. Cell. Biochem. 126 (1993) 93-100