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Volumn 115, Issue 2, 2002, Pages 533-546

A 'single toxin-double lesion' rat model of striatonigral degeneration by intrastriatal 1-methyl-4-phenylpyridinium ion injection: A motor behavioural analysis

Author keywords

Animal model; Multiple system atrophy; Paw reaching; Rotations; Stepping test; Thigmotactic scanning

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; APOMORPHINE; OXIDOPAMINE; QUINOLINIC ACID; TOXIN;

EID: 0037146648     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(02)00401-3     Document Type: Article
Times cited : (54)

References (74)
  • 1
    • 0019954340 scopus 로고
    • Apomorphine-induced ipsilateral turning in rats with unilateral lesions of the parafascicular nucleus
    • Ahlenius S., Anden N.E., Grabowska-Anden M. Apomorphine-induced ipsilateral turning in rats with unilateral lesions of the parafascicular nucleus. Exp. Brain Res. 47:1982;270-276.
    • (1982) Exp. Brain Res. , vol.47 , pp. 270-276
    • Ahlenius, S.1    Anden, N.E.2    Grabowska-Anden, M.3
  • 2
    • 0023028468 scopus 로고
    • +): Regional dopamine neuron uptake, toxicity, and novel rotational behavior following dopamine receptor proliferation
    • +): regional dopamine neuron uptake, toxicity, and novel rotational behavior following dopamine receptor proliferation. Eur. J. Pharmacol. 131:1986;199-209.
    • (1986) Eur. J. Pharmacol. , vol.131 , pp. 199-209
    • Altar, C.A.1    Heikkila, R.E.2    Manzino, L.3    Marien, M.R.4
  • 3
    • 0027970324 scopus 로고
    • Ibotenic acid lesions of the striatum reduce drug-induced rotation in the 6-hydroxydopamine-lesioned rat
    • Barker R., Dunnett S.B. Ibotenic acid lesions of the striatum reduce drug-induced rotation in the 6-hydroxydopamine-lesioned rat. Exp. Brain Res. 101:1994;365-374.
    • (1994) Exp. Brain Res. , vol.101 , pp. 365-374
    • Barker, R.1    Dunnett, S.B.2
  • 4
    • 0022446150 scopus 로고
    • Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid
    • Beal M.F., Kowall N.W., Ellison D.W., Mazurek M.F., Swartz K.J., Martin J.B. Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid. Nature. 321:1986;168-171.
    • (1986) Nature , vol.321 , pp. 168-171
    • Beal, M.F.1    Kowall, N.W.2    Ellison, D.W.3    Mazurek, M.F.4    Swartz, K.J.5    Martin, J.B.6
  • 5
    • 0034993599 scopus 로고    scopus 로고
    • Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: Contribution to the apoptotic theory in Parkinson's disease
    • Blum D., Torch S., Lambeng N., Nissou M., Benabid A., Sadoul R., Verna J. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog. Neurobiol. 65:2001;135-172.
    • (2001) Prog. Neurobiol. , vol.65 , pp. 135-172
    • Blum, D.1    Torch, S.2    Lambeng, N.3    Nissou, M.4    Benabid, A.5    Sadoul, R.6    Verna, J.7
  • 7
    • 0032815680 scopus 로고    scopus 로고
    • Replicating Huntington's disease phenotype in experimental animals
    • Brouillet E., Conde F., Beal M.F., Hantraye P. Replicating Huntington's disease phenotype in experimental animals. Prog. Neurobiol. 59:1999;427-468.
    • (1999) Prog. Neurobiol. , vol.59 , pp. 427-468
    • Brouillet, E.1    Conde, F.2    Beal, M.F.3    Hantraye, P.4
  • 8
    • 0025940503 scopus 로고
    • Nigrostriatal pathway modulates striatum vulnerability to quinolinic acid
    • Buisson A., Plateau V., Plotkine M., Boulu R.G. Nigrostriatal pathway modulates striatum vulnerability to quinolinic acid. Neurosci. Lett. 131:1991;257-259.
    • (1991) Neurosci. Lett. , vol.131 , pp. 257-259
    • Buisson, A.1    Plateau, V.2    Plotkine, M.3    Boulu, R.G.4
  • 9
    • 0001496694 scopus 로고
    • A primate model of Parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • Burns R.S., Chiueh C.C., Markey S.P., Ebert M.H., Jacobowitz D.M., Kopin I.J. A primate model of Parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Natl. Acad. Sci. USA. 80:1983;4546-4550.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 4546-4550
    • Burns, R.S.1    Chiueh, C.C.2    Markey, S.P.3    Ebert, M.H.4    Jacobowitz, D.M.5    Kopin, I.J.6
  • 10
    • 0001980568 scopus 로고
    • Acetylcholinesterase histochemistry
    • Björklund, A., Hökfelt, T. (Eds.). Elsevier, Amsterdam
    • Butcher, L.L., 1983. Acetylcholinesterase histochemistry. In: Björklund, A., Hökfelt, T. (Eds.), Handbook of Chemical Neuroanatomy. Elsevier, Amsterdam, pp. 1-49.
    • (1983) Handbook of Chemical Neuroanatomy , pp. 1-49
    • Butcher, L.L.1
  • 12
    • 0032889986 scopus 로고    scopus 로고
    • Biochemical and anatomical characterization of forepaw adjusting steps in rat models of Parkinson's disease: Studies on medial forebrain bundle and striatal lesion
    • Chang J.W., Wachtel S.R., Young D., Kang U.J. Biochemical and anatomical characterization of forepaw adjusting steps in rat models of Parkinson's disease: studies on medial forebrain bundle and striatal lesion. Neuroscience. 88:1999;617-628.
    • (1999) Neuroscience , vol.88 , pp. 617-628
    • Chang, J.W.1    Wachtel, S.R.2    Young, D.3    Kang, U.J.4
  • 13
    • 0021339035 scopus 로고
    • Neurochemical and behavioral effects of systemic and intranigral administration of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the rat
    • Chiueh C.C., Markey S.P., Burns R.S., Johannessen J.N., Pert A., Kopin I.J. Neurochemical and behavioral effects of systemic and intranigral administration of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the rat. Eur. J. Pharmacol. 100:1984;189-194.
    • (1984) Eur. J. Pharmacol. , vol.100 , pp. 189-194
    • Chiueh, C.C.1    Markey, S.P.2    Burns, R.S.3    Johannessen, J.N.4    Pert, A.5    Kopin, I.J.6
  • 15
    • 0030565585 scopus 로고    scopus 로고
    • Skilled motor deficits in rats induced by ventrolateral striatal dopamine depletions: Behavioral and pharmacological characterization
    • Cousins M.S., Salamone J.D. Skilled motor deficits in rats induced by ventrolateral striatal dopamine depletions: behavioral and pharmacological characterization. Brain Res. 732:1996;186-194.
    • (1996) Brain Res. , vol.732 , pp. 186-194
    • Cousins, M.S.1    Salamone, J.D.2
  • 16
    • 0030042757 scopus 로고    scopus 로고
    • Involvement of ventrolateral striatal dopamine in movement initiation and execution: A microdialysis and behavioral investigation
    • Cousins M.S., Salamone J.D. Involvement of ventrolateral striatal dopamine in movement initiation and execution: a microdialysis and behavioral investigation. Neuroscience. 70:1996;849-859.
    • (1996) Neuroscience , vol.70 , pp. 849-859
    • Cousins, M.S.1    Salamone, J.D.2
  • 17
    • 0023919424 scopus 로고
    • Striatal grafts in rats with unilateral neostriatal lesions - III. Recovery from dopamine-dependent motor asymmetry and deficits in skilled paw reaching
    • Dunnett S.B., Isacson O., Sirinathsinghji D.J.S., Clarke D.J., Björklund A. Striatal grafts in rats with unilateral neostriatal lesions - III. Recovery from dopamine-dependent motor asymmetry and deficits in skilled paw reaching. Neuroscience. 24:1988;813-820.
    • (1988) Neuroscience , vol.24 , pp. 813-820
    • Dunnett, S.B.1    Isacson, O.2    Sirinathsinghji, D.J.S.3    Clarke, D.J.4    Björklund, A.5
  • 18
    • 0019990992 scopus 로고
    • Sensorimotor impairments following localized kainic acid and 6-hydroxydopamine lesions of the neostriatum
    • Dunnett S.B., Iversen S.D. Sensorimotor impairments following localized kainic acid and 6-hydroxydopamine lesions of the neostriatum. Brain Res. 248:1982;121-127.
    • (1982) Brain Res. , vol.248 , pp. 121-127
    • Dunnett, S.B.1    Iversen, S.D.2
  • 19
    • 0019959553 scopus 로고
    • Spontaneous and drug-induced rotation following localized 6-hydroxydopamine and kaïnic acid-induced lesions of the neostriatum
    • Dunnett S.B., Iversen S.D. Spontaneous and drug-induced rotation following localized 6-hydroxydopamine and kaïnic acid-induced lesions of the neostriatum. Neuropharmacology. 21:1982;899-908.
    • (1982) Neuropharmacology , vol.21 , pp. 899-908
    • Dunnett, S.B.1    Iversen, S.D.2
  • 21
    • 0031105818 scopus 로고    scopus 로고
    • + produces progressive neuronal degeneration which is mediated by oxidative stress
    • + produces progressive neuronal degeneration which is mediated by oxidative stress. Exp. Neurol. 144:1997;193-198.
    • (1997) Exp. Neurol. , vol.144 , pp. 193-198
    • Fallon, J.1    Matthews, R.T.2    Hyman, B.T.3    Beal, M.F.4
  • 22
    • 0025651148 scopus 로고
    • Striatonigral degeneration. A clinicopathological study
    • Fearnley J.M., Lees A.J. Striatonigral degeneration. A clinicopathological study. Brain. 113:1990;1823-1842.
    • (1990) Brain , vol.113 , pp. 1823-1842
    • Fearnley, J.M.1    Lees, A.J.2
  • 23
    • 0027999848 scopus 로고
    • Behavioral asymmetries and recovery in rats with different degrees of unilateral striatal dopamine depletion
    • Fornaguera J., Carey R.J., Huston J.P., Schwarting R.K.W. Behavioral asymmetries and recovery in rats with different degrees of unilateral striatal dopamine depletion. Brain Res. 664:1994;178-188.
    • (1994) Brain Res. , vol.664 , pp. 178-188
    • Fornaguera, J.1    Carey, R.J.2    Huston, J.P.3    Schwarting, R.K.W.4
  • 24
    • 0027466922 scopus 로고
    • Behavioral indices of moderate nigro-striatal 6-hydroxydopamine lesion: A preclinical Parkinson's model
    • Fornaguera J., Schwarting R.K.W., Boix F., Huston J.P. Behavioral indices of moderate nigro-striatal 6-hydroxydopamine lesion: a preclinical Parkinson's model. Synapse. 13:1993;179-185.
    • (1993) Synapse , vol.13 , pp. 179-185
    • Fornaguera, J.1    Schwarting, R.K.W.2    Boix, F.3    Huston, J.P.4
  • 25
    • 0030465491 scopus 로고    scopus 로고
    • The placement of a striatal ibotenic acid lesion affects skilled forelimb use and the direction of drug-induced rotation
    • Fricker R.A., Annett L.E., Torres E.M., Dunnett S.B. The placement of a striatal ibotenic acid lesion affects skilled forelimb use and the direction of drug-induced rotation. Brain Res. Bull. 41:1996;409-416.
    • (1996) Brain Res. Bull. , vol.41 , pp. 409-416
    • Fricker, R.A.1    Annett, L.E.2    Torres, E.M.3    Dunnett, S.B.4
  • 27
    • 0028276809 scopus 로고
    • Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat
    • Frim D.M., Uhler T.A., Galpern W.R., Beal M.F., Breakefield X.O., Isacson O. Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat. Proc. Natl. Acad. Sci. USA. 91:1994;5104-5108.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5104-5108
    • Frim, D.M.1    Uhler, T.A.2    Galpern, W.R.3    Beal, M.F.4    Breakefield, X.O.5    Isacson, O.6
  • 28
    • 0035157215 scopus 로고    scopus 로고
    • Simultaneous intrastriatal 6-hydroxydopamine and quinolinic acid injection: A model of early-stage striatonigral degeneration
    • Ghorayeb I., Puschban Z., Fernagut P.O., Scherfler C., Rouland R., Wenning G.K., Tison F. Simultaneous intrastriatal 6-hydroxydopamine and quinolinic acid injection: a model of early-stage striatonigral degeneration. Exp. Neurol. 167:2001;133-147.
    • (2001) Exp. Neurol. , vol.167 , pp. 133-147
    • Ghorayeb, I.1    Puschban, Z.2    Fernagut, P.O.3    Scherfler, C.4    Rouland, R.5    Wenning, G.K.6    Tison, F.7
  • 29
    • 0002635241 scopus 로고    scopus 로고
    • Quantitative histochemistry of cytochrome oxidase activity. Theory, methods and regional brain vulnerability
    • Gonzales-Lima, F. (Ed.). Plenum Press, New York
    • Gonzales-Lima, F., Cada, M., 1998. Quantitative histochemistry of cytochrome oxidase activity. Theory, methods and regional brain vulnerability. In: Gonzales-Lima, F. (Ed.), Cytochrome Oxidase in Neuronal Metabolism and Alzheimer's Disease. Plenum Press, New York, pp. 55-90.
    • (1998) Cytochrome Oxidase in Neuronal Metabolism and Alzheimer's Disease , pp. 55-90
    • Gonzales-Lima, F.1    Cada, M.2
  • 31
    • 0025293675 scopus 로고
    • Met-enkephalin immunoreactivity in the basal ganglia in Parkinson's disease and striatonigral degeneration
    • Goto S., Hirano A., Matsumoto S. Met-enkephalin immunoreactivity in the basal ganglia in Parkinson's disease and striatonigral degeneration. Neurology. 40:1990;1051-1056.
    • (1990) Neurology , vol.40 , pp. 1051-1056
    • Goto, S.1    Hirano, A.2    Matsumoto, S.3
  • 32
    • 0029805036 scopus 로고    scopus 로고
    • Subregional loss of putaminal efferents to the basal ganglia output nuclei may cause Parkinsonism in striatonigral degeneration
    • Goto S., Matsumoto S., Ushio Y., Hirano A. Subregional loss of putaminal efferents to the basal ganglia output nuclei may cause Parkinsonism in striatonigral degeneration. Neurology. 47:1996;1032-1036.
    • (1996) Neurology , vol.47 , pp. 1032-1036
    • Goto, S.1    Matsumoto, S.2    Ushio, Y.3    Hirano, A.4
  • 34
  • 35
    • 0024160479 scopus 로고
    • Different patterns of rotational behavior in rats after dorsal or ventral striatal lesions with ibotenic acid
    • Kafetzopoulos E., Vlaha V., Konitsiotis S. Different patterns of rotational behavior in rats after dorsal or ventral striatal lesions with ibotenic acid. Pharmacol. Biochem. Behav. 29:1988;403-406.
    • (1988) Pharmacol. Biochem. Behav. , vol.29 , pp. 403-406
    • Kafetzopoulos, E.1    Vlaha, V.2    Konitsiotis, S.3
  • 36
    • 0035412898 scopus 로고    scopus 로고
    • Sensory function of basal ganglia
    • Kaji R., Murase N. Sensory function of basal ganglia. Mov. Disord. 16:2001;593-594.
    • (2001) Mov. Disord. , vol.16 , pp. 593-594
    • Kaji, R.1    Murase, N.2
  • 37
    • 0032143368 scopus 로고    scopus 로고
    • Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat
    • Kirik D., Rosenblad C., Björklund A. Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat. Exp. Neurol. 152:1998;259-277.
    • (1998) Exp. Neurol. , vol.152 , pp. 259-277
    • Kirik, D.1    Rosenblad, C.2    Björklund, A.3
  • 38
    • 0027160963 scopus 로고
    • Neuronal cell loss of the striatonigral system in multiple system atrophy
    • Kume A., Takahashi A., Hashizume Y. Neuronal cell loss of the striatonigral system in multiple system atrophy. J. Neurol. Sci. 117:1993;33-40.
    • (1993) J. Neurol. Sci. , vol.117 , pp. 33-40
    • Kume, A.1    Takahashi, A.2    Hashizume, Y.3
  • 39
    • 0031774904 scopus 로고    scopus 로고
    • The definition of multiple system atrophy: A review of recent developments
    • Lantos P.L. The definition of multiple system atrophy: a review of recent developments. J. Neuropath. Exp. Neurol. 57:1998;1099-1111.
    • (1998) J. Neuropath. Exp. Neurol. , vol.57 , pp. 1099-1111
    • Lantos, P.L.1
  • 40
    • 0029981267 scopus 로고    scopus 로고
    • Dopaminergic neuronal degeneration and motor impairments following axon terminal lesion by intrastriatal 6-hydroxydopamine in the rat
    • Lee C.S., Sauer H., Björklund A. Dopaminergic neuronal degeneration and motor impairments following axon terminal lesion by intrastriatal 6-hydroxydopamine in the rat. Neuroscience. 72:1996;641-653.
    • (1996) Neuroscience , vol.72 , pp. 641-653
    • Lee, C.S.1    Sauer, H.2    Björklund, A.3
  • 41
    • 0024439793 scopus 로고
    • The neurotoxicity of 1-methyl-4-phenylpyridinium in cultured cerebellar granule cells
    • Marini A.M., Schwartz J.P., Kopin I.J. The neurotoxicity of 1-methyl-4-phenylpyridinium in cultured cerebellar granule cells. J. Neurosci. 9:1989;3665-3672.
    • (1989) J. Neurosci. , vol.9 , pp. 3665-3672
    • Marini, A.M.1    Schwartz, J.P.2    Kopin, I.J.3
  • 42
    • 0024336026 scopus 로고
    • The organization of the projection from the cerebral cortex to the striatum in the rat
    • McGeorge A.J., Faul R.L. The organization of the projection from the cerebral cortex to the striatum in the rat. Neuroscience. 29:1989;503-537.
    • (1989) Neuroscience , vol.29 , pp. 503-537
    • McGeorge, A.J.1    Faul, R.L.2
  • 44
    • 0032860432 scopus 로고    scopus 로고
    • The selective vulnerability of striatopallidal neurons
    • Mitchell I.J., Cooper A.J., Griffiths M.R. The selective vulnerability of striatopallidal neurons. Prog. Neurobiol. 59:1999;691-719.
    • (1999) Prog. Neurobiol. , vol.59 , pp. 691-719
    • Mitchell, I.J.1    Cooper, A.J.2    Griffiths, M.R.3
  • 45
    • 0026101797 scopus 로고
    • The 'staircase test': A measure of independent forelimb reaching and grasping abilities in rats
    • Montoya C.P., Campbell H.L., Pemberton K.D., Dunnett S.B. The 'staircase test': a measure of independent forelimb reaching and grasping abilities in rats. J. Neurosci. Methods. 36:1991;219-228.
    • (1991) J. Neurosci. Methods , vol.36 , pp. 219-228
    • Montoya, C.P.1    Campbell, H.L.2    Pemberton, K.D.3    Dunnett, S.B.4
  • 46
    • 0030580581 scopus 로고    scopus 로고
    • Effects of α-phenyl-tert-butyl nitrone on neuronal survival and motor function following intrastriatal injections of quinolinate or 3-nitropropionic acid
    • Nakao N., Brundin P. Effects of α-phenyl-tert-butyl nitrone on neuronal survival and motor function following intrastriatal injections of quinolinate or 3-nitropropionic acid. Neuroscience. 76:1997;749-761.
    • (1997) Neuroscience , vol.76 , pp. 749-761
    • Nakao, N.1    Brundin, P.2
  • 47
    • 0026565388 scopus 로고
    • The direction of apomorphine-induced rotation behavior is dependent on the location of excitotoxin lesions in the rat basal ganglia
    • Norman A.B., Norgren R.B., Wyatt L.M., Hildebrand J.P., Sanberg P.R. The direction of apomorphine-induced rotation behavior is dependent on the location of excitotoxin lesions in the rat basal ganglia. Brain Res. 569:1992;169-172.
    • (1992) Brain Res. , vol.569 , pp. 169-172
    • Norman, A.B.1    Norgren, R.B.2    Wyatt, L.M.3    Hildebrand, J.P.4    Sanberg, P.R.5
  • 48
    • 0029064091 scopus 로고
    • Forelimb akinesia in the rat Parkinson model: Differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test
    • Olsson M., Nikkhah G., Bentlage C., Björklund A. Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test. J. Neurosci. 15:1995;3863-3875.
    • (1995) J. Neurosci. , vol.15 , pp. 3863-3875
    • Olsson, M.1    Nikkhah, G.2    Bentlage, C.3    Björklund, A.4
  • 50
    • 0023901528 scopus 로고
    • Motor functions of the striatum in the rat: Critical role of the lateral region in tongue and forelimb reaching
    • Pisa M. Motor functions of the striatum in the rat: critical role of the lateral region in tongue and forelimb reaching. Neuroscience. 24:1988;453-463.
    • (1988) Neuroscience , vol.24 , pp. 453-463
    • Pisa, M.1
  • 51
    • 0029015394 scopus 로고
    • Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by intrastriatal injection of 6-hydroxydopamine
    • Przedborski S., Levivier M., Jiang H., Ferreira M., Jackson-Lewis V., Donaldson D., Togasaki D.M. Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by intrastriatal injection of 6-hydroxydopamine. Neuroscience. 67:1995;631-647.
    • (1995) Neuroscience , vol.67 , pp. 631-647
    • Przedborski, S.1    Levivier, M.2    Jiang, H.3    Ferreira, M.4    Jackson-Lewis, V.5    Donaldson, D.6    Togasaki, D.M.7
  • 52
    • 0027730251 scopus 로고
    • Intrastriatal injection of quinolinic acid or kaïnic acid: Differential patterns of cell survival and the effects of data analysis on outcome
    • Roberts R.C., Ahn A., Swartz K.J., Beal M.F., DiFiglia M. Intrastriatal injection of quinolinic acid or kaïnic acid: differential patterns of cell survival and the effects of data analysis on outcome. Exp. Neurol. 124:1993;274-282.
    • (1993) Exp. Neurol. , vol.124 , pp. 274-282
    • Roberts, R.C.1    Ahn, A.2    Swartz, K.J.3    Beal, M.F.4    DiFiglia, M.5
  • 53
    • 0030596117 scopus 로고    scopus 로고
    • The contralateral cortex contributes to the effects of hemidecortication on neuropeptide Y immunoreactivity in the rat striatum
    • Salin P., Nieoullon A. The contralateral cortex contributes to the effects of hemidecortication on neuropeptide Y immunoreactivity in the rat striatum. Neurosci. Lett. 220:1996;179-182.
    • (1996) Neurosci. Lett. , vol.220 , pp. 179-182
    • Salin, P.1    Nieoullon, A.2
  • 54
    • 0024400046 scopus 로고
    • The quinolinic acid model of Huntington's disease: Locomotor abnormalities
    • Sanberg P.R., Calderon S.F., Giordano M., Tew J., Norman A. The quinolinic acid model of Huntington's disease: locomotor abnormalities. Exp. Neurol. 105:1989;45-53.
    • (1989) Exp. Neurol. , vol.105 , pp. 45-53
    • Sanberg, P.R.1    Calderon, S.F.2    Giordano, M.3    Tew, J.4    Norman, A.5
  • 55
    • 0028220834 scopus 로고
    • Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemical study in the rat
    • Sauer H., Oertel W.H. Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat. Neuroscience. 59:1994;401-415.
    • (1994) Neuroscience , vol.59 , pp. 401-415
    • Sauer, H.1    Oertel, W.H.2
  • 56
    • 0034718190 scopus 로고    scopus 로고
    • Complex motor disturbances in a sequential double lesion rat model of striatonigral degeneration (multiple system atrophy)
    • Scherfler C., Puschban Z., Ghorayeb I., Goebel G.P., Tison F., Jellinger K., Poewe W., Wenning G.K. Complex motor disturbances in a sequential double lesion rat model of striatonigral degeneration (multiple system atrophy). Neuroscience. 99:2000;43-54.
    • (2000) Neuroscience , vol.99 , pp. 43-54
    • Scherfler, C.1    Puschban, Z.2    Ghorayeb, I.3    Goebel, G.P.4    Tison, F.5    Jellinger, K.6    Poewe, W.7    Wenning, G.K.8
  • 57
    • 0026030580 scopus 로고
    • Asymmetries in thigmotactic scanning: Evidence for a role of dopaminergic mechanisms
    • Schwarting R.K., Steiner H., Huston J.P. Asymmetries in thigmotactic scanning: evidence for a role of dopaminergic mechanisms. Psychopharmacology (Berl.). 103:1991;19-27.
    • (1991) Psychopharmacology (Berl.) , vol.103 , pp. 19-27
    • Schwarting, R.K.1    Steiner, H.2    Huston, J.P.3
  • 58
    • 0027454044 scopus 로고
    • A video image analyzing system for open-field behavior in the rat focusing on behavioral asymmetries
    • Schwarting R.K.W., Goldenberg R., Steiner H., Fornaguera J., Huston J.P. A video image analyzing system for open-field behavior in the rat focusing on behavioral asymmetries. J. Neurosci. Methods. 49:1993;199-210.
    • (1993) J. Neurosci. Methods , vol.49 , pp. 199-210
    • Schwarting, R.K.W.1    Goldenberg, R.2    Steiner, H.3    Fornaguera, J.4    Huston, J.P.5
  • 59
    • 0030272769 scopus 로고    scopus 로고
    • The unilateral 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments
    • Schwarting R.K.W., Huston J.P. The unilateral 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments. Prog. Neurobiol. 50:1996;275-331.
    • (1996) Prog. Neurobiol. , vol.50 , pp. 275-331
    • Schwarting, R.K.W.1    Huston, J.P.2
  • 61
    • 0027177628 scopus 로고
    • +) nigral toxicity in the rat by prior decortication or MK-801 treatment: A stereological estimate of neuronal loss
    • +) nigral toxicity in the rat by prior decortication or MK-801 treatment: a stereological estimate of neuronal loss. Neurobiol. Aging. 14:1993;295-301.
    • (1993) Neurobiol. Aging , vol.14 , pp. 295-301
    • Srivastava, R.1    Brouillet, E.2    Beal, M.F.3    Storey, E.4    Hyman, B.T.5
  • 62
    • 0030271246 scopus 로고    scopus 로고
    • Transneuronal degeneration in substantia nigra pars reticulata following striatal excitotoxic injury in adult rat: Time-course, distribution and morphology of cell death
    • Stefanis L., Burke R.E. Transneuronal degeneration in substantia nigra pars reticulata following striatal excitotoxic injury in adult rat: time-course, distribution and morphology of cell death. Neuroscience. 74:1996;997-1008.
    • (1996) Neuroscience , vol.74 , pp. 997-1008
    • Stefanis, L.1    Burke, R.E.2
  • 63
    • 0026719208 scopus 로고
    • 1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism
    • Storey E., Hyman B.T., Jenkins B., Brouillet E., Miller J.M., Rosen B.R., Beal M.F. 1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism. J. Neurochem. 58:1992;1975-1978.
    • (1992) J. Neurochem. , vol.58 , pp. 1975-1978
    • Storey, E.1    Hyman, B.T.2    Jenkins, B.3    Brouillet, E.4    Miller, J.M.5    Rosen, B.R.6    Beal, M.F.7
  • 64
    • 0028990327 scopus 로고
    • Effects of 1-methyl-4-phenylpyridinium on radioligand binding to the NMDA receptor complex
    • Sundstrom E., Mo L.L. Effects of 1-methyl-4-phenylpyridinium on radioligand binding to the NMDA receptor complex. Res. Commun. Mol. Pathol. Pharmacol. 88:1995;131-136.
    • (1995) Res. Commun. Mol. Pathol. Pharmacol. , vol.88 , pp. 131-136
    • Sundstrom, E.1    Mo, L.L.2
  • 65
    • 84982615966 scopus 로고
    • The pathophysiology of Parkinsonism in multiple system atrophy
    • Tison F., Wenning G.K., Daniel S.E., Quinn N.P. The pathophysiology of Parkinsonism in multiple system atrophy. Eur. J. Neurol. 2:1995;435-444.
    • (1995) Eur. J. Neurol. , vol.2 , pp. 435-444
    • Tison, F.1    Wenning, G.K.2    Daniel, S.E.3    Quinn, N.P.4
  • 66
    • 0028796636 scopus 로고
    • Intrastriatal quinolinic acid injections protect against 6-hydroxydopamine-induced lesions of the dopaminergic nigrostriatal pathway
    • Venero J.L., Romero-Ramos M., Revuelta M., Machado A., Cano J. Intrastriatal quinolinic acid injections protect against 6-hydroxydopamine-induced lesions of the dopaminergic nigrostriatal pathway. Brain Res. 672:1995;153-158.
    • (1995) Brain Res. , vol.672 , pp. 153-158
    • Venero, J.L.1    Romero-Ramos, M.2    Revuelta, M.3    Machado, A.4    Cano, J.5
  • 67
    • 0032484557 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor prevents the loss of nigral neurons induced by excitotoxic striatal-pallidal lesions
    • Volpe B.T., Wildmann J., Altar C.A. Brain-derived neurotrophic factor prevents the loss of nigral neurons induced by excitotoxic striatal-pallidal lesions. Neuroscience. 83:1998;741-748.
    • (1998) Neuroscience , vol.83 , pp. 741-748
    • Volpe, B.T.1    Wildmann, J.2    Altar, C.A.3
  • 68
    • 0035808846 scopus 로고    scopus 로고
    • No functional effects of embryonic neuronal grafts on motor deficits in a 3-nitropropionic acid rat model of advanced striatonigral degeneration (multiple system atrophy)
    • Waldner R., Puschban Z., Scherfler C., Seppi K., Jellinger K., Poewe W., Wenning G.K. No functional effects of embryonic neuronal grafts on motor deficits in a 3-nitropropionic acid rat model of advanced striatonigral degeneration (multiple system atrophy). Neuroscience. 102:2001;581-592.
    • (2001) Neuroscience , vol.102 , pp. 581-592
    • Waldner, R.1    Puschban, Z.2    Scherfler, C.3    Seppi, K.4    Jellinger, K.5    Poewe, W.6    Wenning, G.K.7
  • 69
    • 0031815611 scopus 로고    scopus 로고
    • Effects of severity of host striatal damage on the morphological development of intrastriatal transplants in a rodent model of Huntington's disease: Implications for timing of surgical intervention
    • Watts C., Dunnett S.B. Effects of severity of host striatal damage on the morphological development of intrastriatal transplants in a rodent model of Huntington's disease: implications for timing of surgical intervention. J. Neurosurg. 89:1998;267-274.
    • (1998) J. Neurosurg. , vol.89 , pp. 267-274
    • Watts, C.1    Dunnett, S.B.2
  • 70
    • 0000619526 scopus 로고
    • Cortico-striate interrelations in the albino rat
    • Webster K.E. Cortico-striate interrelations in the albino rat. J. Anat. 95:1961;532-544.
    • (1961) J. Anat. , vol.95 , pp. 532-544
    • Webster, K.E.1
  • 71
    • 0029814681 scopus 로고    scopus 로고
    • Reversal of behavioural abnormalities by fetal allografts in a novel rat model of striatonigral degeneration
    • Wenning G.K., Granata R., Laboyrie P.M., Quinn N.P., Jenner P., Marsden C.D. Reversal of behavioural abnormalities by fetal allografts in a novel rat model of striatonigral degeneration. Mov. Disord. 11:1996;522-532.
    • (1996) Mov. Disord. , vol.11 , pp. 522-532
    • Wenning, G.K.1    Granata, R.2    Laboyrie, P.M.3    Quinn, N.P.4    Jenner, P.5    Marsden, C.D.6
  • 73
    • 0034068074 scopus 로고    scopus 로고
    • Towards neurotransplantation in multiple system atrophy: Clinical rationale, pathophysiological basis and preliminary experimental evidence
    • Wenning G.K., Tison F., Scherfler C., Puschban Z., Waldner R., Granata R., Ghorayeb I., Poewe W. Towards neurotransplantation in multiple system atrophy: clinical rationale, pathophysiological basis and preliminary experimental evidence. Cell Transpl. 9:2000;279-288.
    • (2000) Cell Transpl. , vol.9 , pp. 279-288
    • Wenning, G.K.1    Tison, F.2    Scherfler, C.3    Puschban, Z.4    Waldner, R.5    Granata, R.6    Ghorayeb, I.7    Poewe, W.8
  • 74
    • 0023032147 scopus 로고
    • The contributions of motor cortex, nigrostriatal dopamine and caudate-putamen to skilled forelimb use in the rat
    • Whishaw I.Q., O'Connor W.T., Dunnett S.B. The contributions of motor cortex, nigrostriatal dopamine and caudate-putamen to skilled forelimb use in the rat. Brain. 109:1986;805-843.
    • (1986) Brain , vol.109 , pp. 805-843
    • Whishaw, I.Q.1    O'Connor, W.T.2    Dunnett, S.B.3


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