메뉴 건너뛰기




Volumn 1, Issue 4, 2006, Pages 429-434

Angiogenesis inhibitors in clinical oncology

Author keywords

Angiogenesis; Bevacizumab; Renal cell carcinoma; Sorafenib; Sunitinib; Vascular endothelial growth factor; Vatalinib

Indexed keywords

AG 013736; ALPHA2B INTERFERON; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; AP 23573; AZ 6474; BEVACIZUMAB; CILENGITIDE; CP 673 451; EVEROLIMUS; IMATINIB; MONOCLONAL ANTIBODY LM 609; NEXAVAR; PANCREAS ENZYME; SORAFENIB; SUNITINIB; TEMSIROLIMUS; UNCLASSIFIED DRUG; VASCULOTROPIN; VATALANIB;

EID: 33751324377     PISSN: 1872115X     EISSN: 1872115X     Source Type: Journal    
DOI: 10.1016/j.uct.2006.08.006     Document Type: Review
Times cited : (5)

References (36)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 85013312416 scopus 로고
    • Tumor angiogenesis: therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 285 (1971) 1182-1186
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 3
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • Yang J.C., Haworth S., Sherry R.M., Hwu P., Schwartzentruber D.J., Topalian S.L., et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 349 5 (2003) 427-434
    • (2003) N Engl J Med , vol.349 , Issue.5 , pp. 427-434
    • Yang, J.C.1    Haworth, S.2    Sherry, R.M.3    Hwu, P.4    Schwartzentruber, D.J.5    Topalian, S.L.6
  • 6
    • 23844455555 scopus 로고    scopus 로고
    • Final findings from a phase II, placebo-controlled, randomized discontinuation trial (RDT) of sorafenib (Bay 43-9006) in patients with advanced renal cell carcinoma
    • [abstract 4544]
    • Ratain M.J., Eisen T., Stadler W.M., Flaherty K.T., Gore M., Desai A., et al. Final findings from a phase II, placebo-controlled, randomized discontinuation trial (RDT) of sorafenib (Bay 43-9006) in patients with advanced renal cell carcinoma. Proc Am Soc Clin Oncol (2005) [abstract 4544]
    • (2005) Proc Am Soc Clin Oncol
    • Ratain, M.J.1    Eisen, T.2    Stadler, W.M.3    Flaherty, K.T.4    Gore, M.5    Desai, A.6
  • 7
    • 23844558595 scopus 로고    scopus 로고
    • Randomized phase III trial of the Raf kinase and VEGFR inhibitor sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC)
    • [abstract 4510]
    • Escudier B., Szczylik C., Eisen T., Stadler W.M., Schwartz B., Shan M., et al. Randomized phase III trial of the Raf kinase and VEGFR inhibitor sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC). Proc Am Soc Clin Oncol (2005) [abstract 4510]
    • (2005) Proc Am Soc Clin Oncol
    • Escudier, B.1    Szczylik, C.2    Eisen, T.3    Stadler, W.M.4    Schwartz, B.5    Shan, M.6
  • 8
    • 23844480013 scopus 로고    scopus 로고
    • Phase II trials of SU11248 show antitumor activity in second-line therapy for patients with metastatic renal cell carcinoma (RCC)
    • The SU11248 Study Group [abstract 4508]
    • Motzer R.J., Rini B.I., Michaelson M.D., Redman B.G., Hudes G.R., Wilding G., et al., The SU11248 Study Group. Phase II trials of SU11248 show antitumor activity in second-line therapy for patients with metastatic renal cell carcinoma (RCC). Proc Am Soc Clin Oncol (2005) [abstract 4508]
    • (2005) Proc Am Soc Clin Oncol
    • Motzer, R.J.1    Rini, B.I.2    Michaelson, M.D.3    Redman, B.G.4    Hudes, G.R.5    Wilding, G.6
  • 10
    • 14644440555 scopus 로고    scopus 로고
    • Role of vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin D.J., and Ellis L.M. Role of vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23 5 (2005) 1011-1027
    • (2005) J Clin Oncol , vol.23 , Issue.5 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 11
    • 0141988568 scopus 로고    scopus 로고
    • Fundamental concepts of the angiogenic process
    • Folkman J. Fundamental concepts of the angiogenic process. Curr Mol Med 3 7 (2003) 643-651
    • (2003) Curr Mol Med , vol.3 , Issue.7 , pp. 643-651
    • Folkman, J.1
  • 12
    • 27944473690 scopus 로고    scopus 로고
    • VEGF as a key mediator of angiogenesis in cancer
    • Carmeliet P. VEGF as a key mediator of angiogenesis in cancer. Oncology 69 S3 (2005) 4-10
    • (2005) Oncology , vol.69 , Issue.SUPPL.3 , pp. 4-10
    • Carmeliet, P.1
  • 13
    • 2942590261 scopus 로고    scopus 로고
    • Vascular endothelial growth factor as a target for anticancer therapy
    • Ferrara N. Vascular endothelial growth factor as a target for anticancer therapy. Oncologist 9 S1 (2004) 2-10
    • (2004) Oncologist , vol.9 , Issue.SUPPL.1 , pp. 2-10
    • Ferrara, N.1
  • 14
    • 22244452376 scopus 로고    scopus 로고
    • VEGF-targeted therapy: therapeutic potential and recent advances
    • Rosen L.S. VEGF-targeted therapy: therapeutic potential and recent advances. Oncologist 10 (2005) 382-391
    • (2005) Oncologist , vol.10 , pp. 382-391
    • Rosen, L.S.1
  • 15
    • 5044227853 scopus 로고    scopus 로고
    • Renal cell carcinoma: rationale and development of therapeutic inhibitors of angiogenesis
    • Ebbinghaus S.W., and Gordon M.S. Renal cell carcinoma: rationale and development of therapeutic inhibitors of angiogenesis. Hematol Oncol Clin N Am 18 (2004) 1143-1159
    • (2004) Hematol Oncol Clin N Am , vol.18 , pp. 1143-1159
    • Ebbinghaus, S.W.1    Gordon, M.S.2
  • 16
    • 11844254414 scopus 로고    scopus 로고
    • Normailzation of tumor vasculature: an emerging concept in anti-angiogenic therapy
    • Jain R.K. Normailzation of tumor vasculature: an emerging concept in anti-angiogenic therapy. Science 307 (2005) 58-62
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 17
    • 0344330996 scopus 로고    scopus 로고
    • Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal cell carcinoma
    • Gnarra J.R., Duan D., Weng Y., Humphrey J.S., Chen D.Y., Lee S., et al. Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal cell carcinoma. Biochim Biophys Acta 1242 3 (1996) 201-210
    • (1996) Biochim Biophys Acta , vol.1242 , Issue.3 , pp. 201-210
    • Gnarra, J.R.1    Duan, D.2    Weng, Y.3    Humphrey, J.S.4    Chen, D.Y.5    Lee, S.6
  • 18
    • 4644363095 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene and kidney cancer
    • Kaelin Jr. W.G. The von Hippel-Lindau tumor suppressor gene and kidney cancer. Clin Cancer Res 10 18Pt2 (2004) 6290S-6295S
    • (2004) Clin Cancer Res , vol.10 , Issue.18 Pt2
    • Kaelin Jr., W.G.1
  • 19
    • 0037562497 scopus 로고    scopus 로고
    • A murine vascular endothelial growth factor antibody inhibits in vivo growth of human Caki-I renal adenocarcinoma
    • Dagnaes-Hansen F., Rasmussen L.M., Tilton R., Denner L., and Flyvbjerg A. A murine vascular endothelial growth factor antibody inhibits in vivo growth of human Caki-I renal adenocarcinoma. Anticancer Res 23 2B (2003) 1625-1630
    • (2003) Anticancer Res , vol.23 , Issue.2 B , pp. 1625-1630
    • Dagnaes-Hansen, F.1    Rasmussen, L.M.2    Tilton, R.3    Denner, L.4    Flyvbjerg, A.5
  • 20
    • 0028935608 scopus 로고
    • Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis
    • Warren R.S., Yuan H., Matli M.R., Gillett N.A., and Ferrarra N. Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. J Clin Invest 95 (1995) 1789-1797
    • (1995) J Clin Invest , vol.95 , pp. 1789-1797
    • Warren, R.S.1    Yuan, H.2    Matli, M.R.3    Gillett, N.A.4    Ferrarra, N.5
  • 21
    • 23444443230 scopus 로고    scopus 로고
    • Antiangiogenic agents in cancer therapy
    • Lenz H.J. Antiangiogenic agents in cancer therapy. Oncology 19 4Suppl3 (2005) 17-25
    • (2005) Oncology , vol.19 , Issue.4 Suppl3 , pp. 17-25
    • Lenz, H.J.1
  • 22
    • 13844321016 scopus 로고    scopus 로고
    • Mechanism of action and biomarker studies of SU11248 a selective inhibitor of split kinase domain receptor tyrosine kinases (including VEGF receptors, PDGF receptors, c-Kit and Flt3)
    • Potapova O., Laird A., Nannini M., et al. Mechanism of action and biomarker studies of SU11248 a selective inhibitor of split kinase domain receptor tyrosine kinases (including VEGF receptors, PDGF receptors, c-Kit and Flt3). Eur J Cancer 38 s7 (2002) 194
    • (2002) Eur J Cancer , vol.38 , Issue.SUPPL.7 , pp. 194
    • Potapova, O.1    Laird, A.2    Nannini, M.3
  • 23
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel D.B., Laird A.D., Xin X., et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 9 (2003) 327-337
    • (2003) Clin Cancer Res , vol.9 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3
  • 24
    • 78650874372 scopus 로고    scopus 로고
    • SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer
    • Abrams T.J., Lee L.B., Murray L.J., et al. SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol Cancer Ther 2 (2003) 471-478
    • (2003) Mol Cancer Ther , vol.2 , pp. 471-478
    • Abrams, T.J.1    Lee, L.B.2    Murray, L.J.3
  • 25
    • 19944431093 scopus 로고    scopus 로고
    • A phase I study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease
    • Fiedler W., Serve H., Döhner H., Schwittay M., Ottmann O.G., O'Farrell A.M., et al. A phase I study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease. Blood 105 (2005) 986-993
    • (2005) Blood , vol.105 , pp. 986-993
    • Fiedler, W.1    Serve, H.2    Döhner, H.3    Schwittay, M.4    Ottmann, O.G.5    O'Farrell, A.M.6
  • 26
    • 33644847440 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
    • Faivre S., Delbaldo C., Vera K., Robert C., Lozahic S., Lassau N., et al. Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J Clin Oncol 24 (2006) 25-35
    • (2006) J Clin Oncol , vol.24 , pp. 25-35
    • Faivre, S.1    Delbaldo, C.2    Vera, K.3    Robert, C.4    Lozahic, S.5    Lassau, N.6
  • 27
    • 0242438809 scopus 로고    scopus 로고
    • Clinical activity and tolerability of the multi-targeted tyrosine kinase inhibitor SU11248 in patients with metastatic gastrointestinal stromal tumor (GIST) refractory to imatinib mesylate
    • The GIST SU11248 Study Group [abstract 3273]
    • Demetri G.D., George S., Heinrich M.C., Fletcher J.A., Fletcher C.D.M., Desai J., et al., The GIST SU11248 Study Group. Clinical activity and tolerability of the multi-targeted tyrosine kinase inhibitor SU11248 in patients with metastatic gastrointestinal stromal tumor (GIST) refractory to imatinib mesylate. Proc Am Soc Clin Oncol (2003) [abstract 3273]
    • (2003) Proc Am Soc Clin Oncol
    • Demetri, G.D.1    George, S.2    Heinrich, M.C.3    Fletcher, J.A.4    Fletcher, C.D.M.5    Desai, J.6
  • 29
    • 0042019045 scopus 로고    scopus 로고
    • Phase I dose-escalation and pharmacokinetic (PK) study of the VEGF inhibitor PTK787/ZK 222584 (PTK/ZK) in patients with liver metastases
    • [abstract 1142]
    • Drevs J., Mross K., Medinger M., Muller M., Laurent D., Reitsma D., et al. Phase I dose-escalation and pharmacokinetic (PK) study of the VEGF inhibitor PTK787/ZK 222584 (PTK/ZK) in patients with liver metastases. Proc Am Soc Clin Oncol (2003) [abstract 1142]
    • (2003) Proc Am Soc Clin Oncol
    • Drevs, J.1    Mross, K.2    Medinger, M.3    Muller, M.4    Laurent, D.5    Reitsma, D.6
  • 30
    • 7444222477 scopus 로고    scopus 로고
    • Expanded phase I/II study of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with FOLFOX-4 as first-line treatment for patients with metastatic colorectal cancer
    • [abstract 3556]
    • Steward W.P., Thomas A., Morgan B., Wiedenmann B., Bartel C., Vanhoefer U., et al. Expanded phase I/II study of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with FOLFOX-4 as first-line treatment for patients with metastatic colorectal cancer. Proc Am Soc Clin Oncol (2003) [abstract 3556]
    • (2003) Proc Am Soc Clin Oncol
    • Steward, W.P.1    Thomas, A.2    Morgan, B.3    Wiedenmann, B.4    Bartel, C.5    Vanhoefer, U.6
  • 31
    • 33751334800 scopus 로고    scopus 로고
    • Phase I/II study of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor in combination with FOLFIRI as first-line treatment for patients with metastatic colorectal cancer (CRC)
    • [abstract 3605]
    • Trarbach T., Schleucher N., Tewes M., Seeber S., Junker U., Laurent D., et al. Phase I/II study of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor in combination with FOLFIRI as first-line treatment for patients with metastatic colorectal cancer (CRC). Proc Am Soc Clin Oncol (2003) [abstract 3605]
    • (2003) Proc Am Soc Clin Oncol
    • Trarbach, T.1    Schleucher, N.2    Tewes, M.3    Seeber, S.4    Junker, U.5    Laurent, D.6
  • 32
    • 23844548194 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, phase III study in patients with metastatic adenocarcinoma of the colon or rectum receiving first-line chemotherapy with oxaliplatin/5-fluorouracil/leucovorin and PTK787/ZK 222584 or placebo (CONFIRM-1)
    • [abstract 3]
    • Hecht J.R., Trarbach T., Jaeger E., Hainsworth J., Wolff R., Lloyd K., et al. A randomized, double-blind, placebo-controlled, phase III study in patients with metastatic adenocarcinoma of the colon or rectum receiving first-line chemotherapy with oxaliplatin/5-fluorouracil/leucovorin and PTK787/ZK 222584 or placebo (CONFIRM-1). Proc Am Soc Clin Oncol (2005) [abstract 3]
    • (2005) Proc Am Soc Clin Oncol
    • Hecht, J.R.1    Trarbach, T.2    Jaeger, E.3    Hainsworth, J.4    Wolff, R.5    Lloyd, K.6
  • 33
    • 0038204144 scopus 로고    scopus 로고
    • SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
    • O'Farrell, et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood 101 9 (2003) 3597-3605
    • (2003) Blood , vol.101 , Issue.9 , pp. 3597-3605
    • O'Farrell1
  • 34
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 64 (2004) 7099-7109
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm1
  • 35
    • 0034655182 scopus 로고    scopus 로고
    • PTK787/ZK222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular growth factor induced responses and tumor growth after oral administration
    • Wood, et al. PTK787/ZK222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular growth factor induced responses and tumor growth after oral administration. Cancer Res 60 (2000) 2178-2189
    • (2000) Cancer Res , vol.60 , pp. 2178-2189
    • Wood1
  • 36
    • 0242370888 scopus 로고    scopus 로고
    • Further characterization of the potent VEGF/PDGF receptor tyrosine kinase inhibitor, aG013736 in preclinical tumor models for its antiangiogenesis and antitumor activity
    • [abstract 3780]
    • Wickman, et al. Further characterization of the potent VEGF/PDGF receptor tyrosine kinase inhibitor, aG013736 in preclinical tumor models for its antiangiogenesis and antitumor activity. Proc Am Assoc Cancer Res 44 (2003) [abstract 3780]
    • (2003) Proc Am Assoc Cancer Res , vol.44
    • Wickman1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.