Mapping a sex hormone-sensitive gene determining female resistance to liver carcinogenesis in a congenic F344.BN-Hcs4 rat

Cancer Research

Volumn 66, Issue 21, 2006, Pages 10384-10390

  De Miglio, Maria R ^a   Virdis, Patrizia ^a   Calvisi, Diego F ^a   Frau, Maddalena ^a   Muroni, Maria R ^a   Simile, Maria M ^a   Daino, Lucia ^a   Careddu, Giovanni M ^a   Sanna Passino, Eraldo ^a   Pascale, Rosa M ^a   Feo, Francesco ^a  

^a UNIVERSITY OF SASSARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS ANTIGEN; ESTRADIOL; SEX HORMONE;

ALLELE; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENETIC SUSCEPTIBILITY; GONADECTOMY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT;

ANIMALS; CHROMOSOME MAPPING; ESTROGEN RECEPTOR ALPHA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GONADAL STEROID HORMONES; LIVER NEOPLASMS, EXPERIMENTAL; MALE; RATS; RATS, INBRED BN; RATS, INBRED F344; RECEPTORS, ANDROGEN; RECOMBINATION, GENETIC; SEX FACTORS;

EID: 33751291248     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-2881     Document Type: Article

References (40)

1. Feo F, De Miglio MR, Simile MM, et al. Hepatocellular carcinoma as a complex polygenic disease. Interpretive analysis of recent developments on genetic predisposition. Biochim Biophys Acta Cancer Rev 2006;1765:126-47.
2. Johnson PJ, Krasner N, Portmann B, Eddleston AL, Williams R. Hepatocellular carcinoma in Great Britain: influence of age, sex, HBsAg status, and aetiology of underlying cirrhosis. Gut 1978;19:1022-6.
3. Drinkwater NR. The interactions of genes and hormones in murine hepatocarcinogenesis. In: Cockburn A, Smith L, editors. Nongenotoxic carcinogenesis. New York: Springer-Verlag; 1994. p. 219-30.
4. Vesselinovitch SD. Perinatal mouse liver carcinogenesis as a sensitive carcinogenesis model and the role of sex hormonal environment in tumor development. In: Stevenson DE, McClain RM, Popp JA, Slaga TJ, Ward JM, Pitot HC, editors. Mouse liver carcinogenesis: mechanisms and species comparisons. Vol. 331. New York: AR Liss; 1990. p. 53-68.
5. Blanck A, Eriksson LC, Gustafsson JA, Porsch Hallstrom I. Sex-differentiated and growth-hormone-regulated mitoinhibition in rat liver during treatment with 2-acetylaminofluorene and partial hepatectomy in the resistant hepatocyte model. Carcinogenesis 1991;12:1259-64.
6. Shimizu I, Yasuda M, Mizobuchi Y, et al. Suppressive effect of oestradiol, on chemical hepatocarcinogenesis in rats. Gut 1998;42:112-9.
7. He WW, Kumar MV, Tindall DJ. A frameshift mutation in the androgen receptor gene causes complete androgen insensitivity in the testicular-feminized mouse. Nucleic Acids Res 1991;19:2373-8.
8. Shimizu I. Impact of oestrogens on the progression of liver disease. Liver Int 2003;23:63-9.
9. Yoshino K, Komura S, Watanabe I, Nakagawa Y, Yagi K. Effect of oestrogens on serum and liver peroxide levels in mice. J Clin Biochem Nutr 1987;3:233-40.
10. Chen J, Li Y, Lavigne JA, Trush MA, Yager JD. Increased mitochondrial superoxide production in rat liver mitochondria, rat hepatocytes, and HepG2 cells following ethinyl estradiol treatment. Toxicol Sci 1999;51:224-35.
11. Colantoni A, La Paglia N, De Maria N, et al. Influence of sex hormonal status on alcohol-induced oxidative injury in male and female rat liver. Alcohol Clin Exp Res 2000;24:1467-73.
12. Bugni JM, Poole TM, Drinkwater NR. The little mutation suppresses DEN-induced hepatocarcinogenesis in mice and abrogates genetic and hormonal modulation of susceptibility. Carcinogenesis 2001;22:1853-62.
13. Jansson JO, Ekberg S, Isaksson O, Mode A, Gustafsson JA. Imprinting of growth hormone secretion, body growth, and hepatic steroid metabolism by neonatal testosterone. Endocrinology 1985;117:1881-9.
14. Poole TM, Drinkwater NR. Two genes abrogate the inhibition of murine hepatocarcinogenesis by ovarian hormones. Proc Natl Acad Sci U S A 1996;93:5848-53.
15. De Miglio MR, Pascale RM, Simile MM, et al. Chromosome mapping of multiple loci affecting the genetic predisposition to rat liver carcinogenesis. Cancer Res 2002;62:4459-63.
16. INK4A activity in rat liver carcinogenesis and human liver cancer. Hepatology 2005;4:1310-9.
17. Markel P, Shu P, Ebelliong C, et al. Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains. Nat Genet 1997;17:280-4.
18. Solt DB, Medline A, Farber E. Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis. Am J Pathol 1977;88:595-618.
19. De Miglio MR, Simile MM, Muroni MR, et al. c-myc overexpression and amplification correlate with progression of preneoplastic liver lesions to malignancy in the poorly susceptible Wistar rat strain. Mol Carcinog 1999;2:21-9.
20. Yu MW, Yang YC, Yang SY, et al. Hormonal markers and hepatitis B virus-related hepatocellular carcinoma risk: a nested case-control study among men. J Natl Cancer Inst 2001;93:1644-51.
21. Velazquez I, Alter BP. Androgens and liver tumors: Fanconi's anemia and non-Fanconi's conditions. Am J Hematol 2004;77:257-67.
22. Yoon G, Kim JY, Choi YK, Won YS, Lim IK. Direct activation of TGF-β1 transcription by androgen and androgen receptor complex in Huh7 human hepatoma cells and its tumor in nude mice. J Cell Biochem 2006;97:393-411.
23. Bilger A, Bennett LM, Carabeo RA, et al. A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines. Genetics 2004;167:859-66.
24. Altucci L, Addeo R, Cicatiello L, et al. 17β-Estradiol induces cyclin D1 gene transcription, p36D1-34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cells. Oncogene 1996;12:2315-24.
25. Perillo B, Sasso A, Abbondanza C, Palumbo G. 17β-Estradiol inhibits apoptosis in MCF-7 cells, inducing bcl-2 expression via two estrogen-responsive elements present in the coding sequence. Mol Cell Biol 2000;20:2890-901.
26. Pascale RM, Simile MM, De Miglio MR, et al. Cell cycle deregulation in liver lesions of rats with and without genetic predisposition to hepatocarcinogenesis. Hepatology 2002;35:1341-50.
27. Arnal JF, Gourdy P, Elhage R, et al. Estrogens and atherosclerosis. Eur J Endocrinol 2004;150:113-7.
28. Gregg D, Goedken E, Gaikin M, Wendell D, Gorski J. Decreased expression of carboxypeptidase E protein is correlated to estrogen-induction of pituitary tumors. Mol Cell Endocrinol 1996;117:219-25.
29. Hammond C, Jeffers L, Carr BI, Simon D. Multiple genetic alterations, 4q28, a new suppressor region, and potential gender differences in human hepatocellular carcinoma. Hepatology 1999;29:1479-85.
30. Bluteau O, Beaudoin JC, Pasturaud P, et al. Specific association between alcohol intake, high grade of differentiation and 4q34-35 deletions in hepatocellular carcinomas identified by high resolution allelotyping. Oncogene 2002;21:1225-32.
31. Gachotte D, Eckstein J, Barbuch R, Hughes T, Roberts C, Bard MA. novel gene conserved from yeast to humans is involved in sterol biosynthesis. J Lipid Res 2001;42:150-4.
32. fat mice. Cell 1997;88:73-83.
33. Agutter PS. Role of the cytoskeleton in nucleocytoplasmic RNA and protein distributions. Biochem Soc Trans 1991;19:1094-8.
34. Lauffenburger DA, Horwitz AF. Cell migration: a physically integrated molecular process. Cell 1996;84:359-69.
35. Bu X, Avraham HK, Li X, et al. Mayven induces c-Jun expression and cyclin D1 activation in breast cancer cells. Oncogene 2005;24:2398-409.
36. Ogawa T, Higashi S, Kawarada Y, Mizumoto R. Role of reactive oxygen in synthetic estrogen induction of hepatocellular carcinomas in rats and preventive effect of vitamins. Carcinogenesis 1995;16:831-6.
37. Villa E, Camellini L, Dugani A, et al. Variant estrogen receptor messenger RNA species detected in human primary hepatocellular carcinoma. Cancer Res 1995;55:498-500.
38. Villa E, Dugani A, Moles A, et al. Variant liver estrogen receptor transcripts already occur at an early stage of chronic liver disease. Hepatology 1998;27:983-8.
39. Villa E, Colantoni A, Camma C, et al. Estrogen receptor classification for hepatocellular carcinoma: comparison with clinical staging systems. J Clin Oncol 2003;21:441-6.
40. Deng G, Zhou G, Zhai Y, et al. Association of estrogen receptor α polymorphisms with susceptibility to chronic hepatitis B virus infection. Hepatology 2004;40:318-26.