Improving drug discovery from microorganisms

Natural Products: Drug Discovery and Therapeutic Medicine

Volumn , Issue , 2005, Pages 95-106

  Farnet, Chris M ^a   Zazopoulos, Emmanuel ^a  

^a INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

Author keywords

actinomycetes; bioinformatics; dereplication; drug discovery; fermentation; genomics; Natural products; structure elucidation

Indexed keywords

EID: 20444501937     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-59259-976-9_5     Document Type: Chapter

References (5)

1. Bentley SD, Chater KF, Cerdeno-Tarraga AM, et al. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3 (2). Nature 2002;417:141-147.
2. Omura S, Ikeda H, Ishikawa J, et al. Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. Proc Natl Acad Sci USA 2001;98:12, 215-12, 220.
3. Zazopoulos E, Huang K, Staffa A, et al. A genomics-guided approach for discovering and expressing cryptic metabolic pathways. Nat Biotechnol 2003;21:187-190.
4. Miyamura S, Ogasawara N, Otsuka H, et al. Antibiotic No. 5879, a new water-soluble antibiotic against Gram-negative bacteria. J Antibiotics 1972;25:610-612.
5. Miyamura S, Ogasawara N, Otsuka H, et al. Antibiotic 5879 produced by Streptomyces aizunensis, identical with bicyclomycin. J Antibiotics 1973;26:479-484.