Flavonoids from Italian multifloral honeys reduce the extracellular ferricyanide in human red blood cells

Journal of Agricultural and Food Chemistry

Volumn 54, Issue 21, 2006, Pages 8328-8334

  Fiorani, Mara ^a   Accorsi, Augusto ^a   Blasa, Manuela ^a   Diamantini, Giuseppe ^a   Piatti, Elena ^a  

^a UNIVERSITY OF URBINO   (Italy)

Author keywords

Antioxidants; Ferricyanide; Flavonoids; Honey; Trans plasma membrane oxidoreductase

Indexed keywords

FERRICYANIDE; FLAVONOID;

ARTICLE; BLOOD; CHEMISTRY; DRUG EFFECT; ERYTHROCYTE; ERYTHROCYTE MEMBRANE; FLOWER; HONEY; ITALY; METABOLISM; OXIDATION REDUCTION REACTION;

ERYTHROCYTE MEMBRANE; ERYTHROCYTES; FERRICYANIDES; FLAVONOIDS; FLOWERS; HONEY; ITALY; OXIDATION-REDUCTION;

EID: 33751251683     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf061602q     Document Type: Article

References (46)

1. Steinmetz, K. A.; Potter, J. D. Vegetables, fruit and cancer. I. Epidemiology. Cancer Causes Control 1991, 5, 325-337.
2. Steinmetz, K. A.; Potter, J. D. Vegetables, fruit and cancer. II. Mechanisms. Cancer Causes Control 1991, 5, 427-442.
3. Richter, M.; Ebermann, R.; Marian, B. Quercetin-induced apoptosis in colorectal tumor cells: possible role of EGF receptor signaling. Nutr. Cancer 1999, 34, 88-99.
4. Afanas'ev, I. B.; Dorozhko, A. I.; Brodskii, A. W.; Korstyuk, V. A.; Potapovich, A. I. Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation. Biochem. Pharmacol. 1989, 38, 1763-1768.
5. Bors, W.; Heller, W.; Michel, C.; Saran, M. Flavonoids as antioxidants: determinations of radical scavenging efficiences. Methods Enzymol. 1990, 234, 343-355.
6. Rice-Evans, C. A.; Miller, N.; Paganga, G. Antioxidant properties of phenolic compounds. Trends Plant Sci. 1997, 2, 152-159.
7. Ciolino, H. P.; Daschner, P. J.; Yeh, G. C. Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that effect CYP1A1 transcription differentially. Biochem. J. 1999, 340, 715-722.
8. Chan, H. Y.; Wang, H.; Tsang, D. S. C.; Chen, Z.-Y.; Leung, L. K. Screening of chemopreventive tea polyphenols against PAH genotoxicity in breast cancer cells by a XRE-luciferase reporter construct. Nutr. Cancer 2003, 46, 93-100.
9. Leung, L. K.; Po, L. S.; Lau, T. Y.; Yuen, Y. M. Effect of dietary flavonols on estrogen receptor transactivation and cell death induction. Br. J. Nutr. 2004, 91, 831-839.
10. Williams, R. J.; Spencer, J. P.; Rice Evans, C. Flavonoids: antioxidants or signaling molecules? Free Radical Biol. Med. 2004, 7, 838-849.
11. Gheldof, N.; Engeseth, N. J. Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of in vitro lipoprotein oxidation in human serum samples. J. Agric. Food Chem. 2002, 50, 3050-3055.
12. Molan, P. C. The antibacterial activity of honey. 2. Variation in the potency of the antibacterial activity. Bee World 1992, 73, 59-76.
13. Postmes, T.; van den Bogaard, A. E.; Hazen, M. Honey for wounds, ulcers, and skin graft preservation. Lancet 1993, 341, 756-757.
14. Molan, P. C. Why honey is effective as a medicine. Its use in modern medicine. Bee World 1999, 80, 80-92.
15. Ali, A. T.; Al-Swayeh, O. A.; Al-Humayyd, M. S.; Mustafa, A. A.; Al-Rashed, R. S.; Al-Tuwaijiri, A. S. Natural honey prevents ischaemia-reperfusion-induced gastric mucosal lesions and increased vascular permeability in rats. Eur. J. Gastroenterol. Hepatol. 1997, 9, 1101-1107.
16. Antony, S. M.; Rieck, J. R.; Dawson, P. L. Effect of dry honey on oxidation in turkey breast meat. Poult. Sci. 2000, 79, 1846-1850.
17. McKibben, J.; Engeseth, N. J. Honey as a protective agent against lipid oxidation in ground turkey. J. Agric. Food Chem. 2002, 50, 592-595.
18. Oszmianski, J.; Lee, C. Y. Inhibition of polyphenol oxidase activity and browning by honey. J. Agric. Food Chem. 1990, 38, 1892-1895.
19. Chen, L.; Mehta, A.; Berenbaum, M.; Zangerl, A. R.; Engeseth, N. J. Honeys from diferent floral sources as inhibitors of enzymatic browning in fruit and vegetable homogenates. J. Agric. Food Chem. 2000, 48, 4997-5000.
20. Blasa, M.; Candiracci, M.; Accorsi, A.; Piacentini, M. P.; Albertini, M. C.; Piatti, E.; Raw Millefiori honey is packed full of antioxidants. Food Chem. 2006, 97, 217-222.
21. Fiorani, M.; De Sanctis, R.; De Bellis, R.; Dachà, M. Intracellular flavonoid as electron donors for extracellular ferricyanide reduction in human erythrocytes. Free Radical Biol. Med. 2002, 32, 64-72.
22. Fiorani, M.; Accorsi, A.; Cantoni, O. Human red blood cells as a natural flavonoid reservoir. Free Radical Res. 2003, 37, 1331-1338.
23. Fiorani, M.; Accorsi, A. Dietary flavonoids as intracellular substrates for an erythrocyte trans-plasma membrane oxidoreductase activity. Br. J. Nutr. 2005, 94, 1-9.
24. May, J. M.; Qu, Z. C.; Whitesell, R. R.; Cobb, C. E. Ascorbate recycling in human erythrocytes: role of GSH in reducing dehydroascorbate. Free Radical Biol. Med. 1996, 20, 543-551.
25. Kennett, E. C.; Kuchel, P. W. Redox reaction and electron transfer across the red cell membrane. IUBMB Life 2003, 55, 375-385.
26. Gheldof, N.; Wang, X.-H.; Engeseth, N. J. Identification and quantification of antioxidant components of honey from various floral sources. J. Agric. Food Chem. 2002, 50, 5870-5877.
27. Zhishen, J.; Mengcheng, T.; Jianming, W. The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chem. 1999, 64, 555-559.
28. Avron, M.; Shavit, N. A sensitive simple method for determination of ferrocyanide. Anal. Biochem. 1963, 6, 549-555.
29. Day, A. J.; Bao, Y.; Morgan, M. R. A.; Williamson, G. Conjugation position of quercetin glucuronides and effect on biological activity. Free Radical Biol. Med. 2000, 29, 1234-1243.
30. 13C-NMR studies of transmembrane electron transfer to extracellular ferricyanide in human erythrocytes. Eur. J. Biochem. 1997, 246, 638-645.
31. 13C-NMR studies of vitamin C transport and its redox cycling in human erythrocytes. Biochemistry 1998, 37, 7578-7588.
32. May, J. M.; Mendiratta, S.; Qu, Z. C.; Loggins, E. Vitamin C recycling and function in human monocytes U-937 cells. Free Radical Biol. Med. 1999, 26, 1513-1523.
33. May, J. M. Is ascorbic acid an antioxidant for the plasma membrane? FASEB J. 1999, 13, 995-1006.
34. del Castillo-Olivares, A.; Medina, M. A.; Nunez. de Castro, I.; Marquez, J. Purification and characterization of a plasma membrane ferricyanide-utilizing NADH dehydrogenase from Ehrlich tumour cells. Biochem. J. 1996, 314, 587-593.
35. Vaillant, F.; Larm, J. A.; McMullen, G. L.; Wolvetang, E. J.; Lawen, A. Effectors of the mammalian plasma membrane NADH-oxidoreductase system. Short-chain ubiquinone analogues as potent stimulators. J. Bioenerg. Biomembr. 1996, 28, 531-540.
36. VanDuijn, M. M.; Van den Zee, J.; VanSteveninck, J.; Van den Broek, P. J. A. Ascorbate stimulates ferricyanide reduction in HL-60 cells through a mechanism distinct from the NADH-dependent plasma membrane reductase. J. Biol. Chem. 1998, 273, 13415-13420.
37. May, J. M.; Qu, Z.-C. Ascorbate-dependent electron transfer across the human erythrocyte membrane. Biochim. Biophys. Acta. 1999, 1421, 19-31.
38. May, J. M.; Qu, Z.-C.; Morrow, J. D.; Cobb, C. E. Ascorbate-dependent protection of human erythrocytes against oxidant stress generated by extracellular diazobenzene sulfonate. Biochem. Pharmacol. 2000, 60, 47-53.
39. Martos, I.; Cossentini, M.; Ferreres, F.; Tomas-Barberan, F. A. Flavonoid composition of tunisian honeys and propolis. J. Agric. Food Chem. 1997, 45, 2824-2829.
40. Gil, M. I.; Ferreres, F.; Ortiz, A.; Subra, E.; Tomas-Barberan, F. A. Plant phenolic metabolites and floral origin of rosemary honey. J. Agric. Food Chem. 1995, 43, 2833-2838.
41. Ferreres, F.; Tomás-Barberan, F. A.; Soler, C.; García-Viguera, C.; Ortiz, A.; Tomás Morente, F. A simple extractive technique for honey flavonoid HPLC analysis. Apidologie 1994, 25, 21-30.
42. Rice Evans, C.; Miller, N. J.; Paganga, G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radical Biol. Med. 1996, 20, 933-956.
43. Cao, G.; Sofic, E.; Prior, R. L. Antioxidant and prooxidant behaviour of flavonoids: structure-activity relationships. Free Radical Biol. Med. 1997, 22, 749-960.
44. Arora, A.; Nair, M. G.; Strasburg, G. M. Structure-activity relationships for antioxidant activities of a series of flavonoids in a liposomal system. Free Radical Biol. Med. 1998, 24, 1355-1363.
45. Kennett, E. C.; Ogawa, E.; Agar, N. S.; Godwin, I. R.; Bubb, W. A.; Kuchel, P. W. Investigation of methaemoglobin reduction by extracellular NADH in mammalian erythrocytes. Int. J. Biochem. Cell. Biol. 2005, 37, 1438-1445.
46. Kennett, E. C.; Bubb, W. A.; Bansal, P.; Alewood, P.; Kuchel, P. W. NMR studies of exchange between intra- and extracellular glutathione in human erythrocytes. Redox Rep. 2005, 10, 83-90.