HIV controllers: a homogeneous group of HIV-1 infected patients with a spontaneous control of viral replication;Les « HIV controllers » : un groupe homogène de patients infectés par le VIH avec un contrôle spontané de la réplication virale

Pathologie Biologie

Volumn 54, Issue 10, 2006, Pages 566-571

  Lambotte, O ^a   Delfraissy, J F ^a  

^a BICÊTRE HOSPITAL   (France)

Author keywords

CD8 T cell; HIV; Long term non progressor; viral DNA; Viral replication

Indexed keywords

ANTIRETROVIRUS AGENT; VIRUS DNA; VIRUS RNA;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; SEROLOGY; VIRUS LOAD; VIRUS REPLICATION; ACQUIRED IMMUNE DEFICIENCY SYNDROME; CD4 LYMPHOCYTE COUNT; DISEASE TRANSMISSION; HEALTH SURVEY; IMMUNOLOGY; PATHOGENICITY; PHYSIOLOGY; VIRION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; CD4 LYMPHOCYTE COUNT; CD8-POSITIVE T-LYMPHOCYTES; HEALTH SURVEYS; HIV INFECTIONS; HIV-1; HUMANS; VIRION; VIRUS REPLICATION;

EID: 33751238808     PISSN: 03698114     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.patbio.2006.07.035     Document Type: Article

References (18)

1. Hogan C.M., and Hammer S.M. Host determinants in HIV infection and disease. Ann. Intern. Med. 134 (2001) 761-776
2. Migueles S.A., Sabbaghian M.S., Shupert W.L., et al. HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors. Proc. Natl. Acad. Sci. USA 97 (2000) 2709-2714
3. Cao Y., Qin L., Zhang L., Safrit J., and Ho D.D. Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. N. Engl. J. Med. 332 (1995) 201-208
4. Greenough T.C., Brettler D.B., Kirchhoff F., et al. Long-term nonprogressive infection with human immunodeficiency virus type 1 in a hemophilia cohort. J. Infect. Dis. 180 (1999) 1790-1802
5. Migueles S.A., Laborico A.C., Shupert W.L., et al. HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nat. Immunol. 3 (2002) 1061-1068
6. Lefrere J.J., Morand-Joubert L., Mariotti M., et al. Even individuals considered as long-term nonprogressors show biological signs of progression after 10 years of Human Immunodeficiency Virus infection. Blood 90 (1997) 1133-1140
7. Strathdee S.A., Veugelers P.J., Page-Shafer K.A., et al. Lack of consistency between five definitions of nonprogression in cohorts of HIV-infected seroconverters. AIDS 10 (1996) 959-965
8. Flores-Villanueva P.O., Yunis E.J., Delgado J.C., et al. Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity. Proc. Natl. Acad. Sci. USA 98 (2001) 5140-5145 (Epub 2001 Apr 17)
9. Rodes B., Toro C., Paxinos E., et al. Differences in disease progression in a cohort of long-term non-progressors after more than 16 years of HIV-1 infection. AIDS 18 (2004) 1109-1116
10. Madec Y., Boufassa F., Rouzioux C., and Delfraissy J.F. Meyer L for the SEROCO study group. Spontaneously controlled long-term viremia in HIV-1 seroconverters: an uncommon phenomenon?. Clin. Inf. Dis. 40 (2005) 1350-1354
11. Meyer L., Magierowska M., Hubert J.B., et al. Early protective effect of CCR-5 delta 32 heterozygosity on HIV-1 disease progression: relationship with viral load. The SEROCO Study Group. AIDS 11 (1997) F73-F78
12. Rouzioux C., Hubert J.B., Burgard M., et al. Early levels of HIV-1 DNA in Peripheral Blood Mononuclear Cells are predictive of disease progression independently of HIV-1 RNA levels and CD4+ cell counts. J. Infect. Dis. 192 (2005) (in press)
13. Lacabaratz-Porret C., Urrutia A., Doisne J.M., et al. Impact of antiretroviral therapy and changes in virus load on human immunodeficiency virus (HIV)-specific T cell responses in primary HIV infection. J. Infect. Dis. 187 (2003) 748-757
14. Dalod M., Dupuis M., Deschemin J.C., et al. Broad, intense anti-human immunodeficiency virus (HIV) ex vivo CD8(+) responses in HIV type 1-infected patients: comparison with anti-Epstein-Barr virus responses and changes during antiretroviral therapy. J. Virol. 73 (1999) 7108-7116
15. Williams C.F., Klinzman D., Yamashita T.E., et al. Persistent GB virus C infection and survival in HIV-infected men. N. Engl. J. Med. 350 (2004) 981-990
16. Lambotte O., Boufassa F., Madec Y., et al. HIV controllers: a homogeneous group of HIV-1 infected patients with spontaneous control of viral replication. Clin. Inf. Dis. 41 (2005) 1053-1056
17. Trkola A. HIV-host interactions: vital to the virus and key to its inhibition. Curr. Opin. Microbiol. 7 (2004) 407-411
18. e Congress of Retroviruses and Opportunistic Infections, Denver, Février 2006, CA 298.