In vitro H2AX phosphorylation and micronuclei induction in human fibroblasts across the Bragg curve of a 577 MeV/nucleon Fe incident beam

Radiation Measurements

Volumn 41, Issue 9-10, 2006, Pages 1209-1215

  Desai, N ^a   Sodolak, J ^b   Gersey, B ^b   Durante, M ^c   Lin, Z W ^d   Rusek, A ^e   Cucinotta, F A ^a   Wu, H ^a  

^a NASA JOHNSON SPACE CENTER   (United States)

^b PRAIRIE VIEW A AND M UNIVERSITY   (United States)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d UNIVERSITY OF ALABAMA IN HUNTSVILLE   (United States)

^e BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

Bragg curve; H2AX; High LET; Micronuclei; Shielding

Indexed keywords

ELEMENTARY PARTICLES; HIGH ENERGY PHYSICS; PROTON BEAMS; RADIATION EFFECTS; RADIATION SHIELDING;

BRAGG CURVE; H2AX; LINEAR ENERGY TRANSFER (LET); MICRONUCLEI;

CELLS;

EID: 33751238174     PISSN: 13504487     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radmeas.2006.04.031     Document Type: Article

References (33)

1. Alpen E.L. Radiation Biophysics (1990), Prentice-Hall, New Jersey pp. 304-306
2. Banath J., and Olive P. Expression of phosphorylated histone H2AX as a surrogate of cell killing by drugs that create DNA double-strand breaks. Cancer Res. 63 (2003) 4347-4350
3. Courdi A., Brassart N., Herault J., Gabillat J., Mari D., Pignol J., and Chauvel P. Changes in biological effectiveness with depth of the Medicyc neutron therapy beam. Bull. Cancer Radiother. 83 (1996) 47-49
4. Cucinotta F.A., Wilson J.W., Shavers M.R., and Katz R. Effects of track structure and cell inactivation on the calculation of heavy ion mutation rates in mammalian cells. Int. J. Radiat. Biol. 69 (1995) 593-600
5. Cucinotta F.A., Wilson J.W., Shinn J.L., Badavi F.F., and Badhwar G.D. Effects of target fragmentation on evaluation of LET spectra from space radiations: implications for space radiation protection studies. Radiat Meas. 269 (1996) 23-34
6. Desai N., Davis E., O'Neill P., Durante M., Cucinotta F.A., and Wu H. Immunofluorescent detection of DNA double strand breaks induced by high-LET irradiation. Radiat. Res. 164 (2005) 518-522
7. Durante M. Influence of the shielding on the space radiation biological effectiveness. Phys. Med. 17 (2001) 269-271
8. Durante M., Furusawa Y., Majima H., Kawata T., and Gotoh E. Association between G2-phase block and repair of radiation-induced chromosome fragments in human lymphocytes. Radiat. Res. 151 (1999) 670-676
9. Durante M., Gialanella G., Grossi G., Pugliese M., Scampoli P., Kawata T., Yasuda N., and Furusawa Y. Influence of the shielding on the induction of chromosomal aberrations in human lymphocytes exposed to high-energy iron ions. J. Radiat. Res. 43 (2002) S107-S111
10. Durante M., George K., Gialanella G., La Tessa C., Manti L., Miller J., Pugliese M., Scampoli P., and Cucinotta F.A. Cytogenetic effects of high-energy iron ions. dependence on shielding thickness and material. Radiat. Res. 164 (2005) 571-576
11. Fenech M., and Morley A.A. Cytokinesis-block micronucleus method in human lymphocytes: effect of in vivo ageing and low dose X-irradiation. Mutat. Res. 161 (1986) 193-198
12. Fenech M., Chang W.P., Kirsch-Volders M., Holland N., Bonassi S., and Zeiger E. Human micronucleus project HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures. Mutat. Res. 534 (2003) 65-75
13. George K., Willingham V., Wu H., Gridley D., Nelson G., and Cucinotta F.A. Chromosome aberrations in human lymphocytes induced by 250 MeV protons: effects of dose, dose rate and shielding. Adv. Space. Res. 30 (2002) 891-899
14. Grossi G., Durante M., Gialanella G., Pugliese M., Scampoli P., Kawata T., Yasuda N., and Furusawa Y. Chromosomal aberrations induced by high-energy iron ions with shielding. Adv. Space Res. 33 (2004) 1495-1503
15. Heilmann J., Taucher-Scholz G., Haberer T., Scholz M., and Kraft G. Measurement of intracellular dna double-strand break induction and rejoining along the track of carbon and neon particle beams in water. Int. J. Radiat. Oncol. Biol. Phys. 34 (1996) 599-608
16. Jakob B., Scholz M., and Taucher-Scholz G. Biological imaging of heavy charged-particle tracks. Radiat. Res. 159 (2003) 676-684
17. Kanai T., Endo M., Misohara S., Miyahara N., Koyama-Ito H., Tomura H., Matsufuji N., Futami Y., Fukumura A., Hiraoka T., Furusawa Y., Ando K., Suzuki M., Soga F., and Kawachi K. Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 44 (1999) 201-210
18. Katz R., Ackerson B., Bomayoonfar M., and Scharma S.C. Inactivation of cells by heavy ion bombardment. Radiat. Res. 47 (1971) 402-425
19. Kraft G. Radiotherapy with heavy ions: radiobiology, clinical indications and experience and GSI, Darmstadt. Tumori. 84 (1998) 200-204
20. Lucke-Huhle C., Blakely E.A., Chang P.Y., and Tobias C.A. Drastic G2 arrest in mammalian cells after irradiation with heavy-ion beams. Radait. Res. 79 (1979) 97-112
21. National Academy of Sciences, 1997. Radiation Hazards to Crews on Interplanetary Missions. Report of the Task Group on the Biological Effects of Space Radiation, National Academy Press, Washington DC, 1997.
22. Nelson G.A. Fundamental space radiobiology. Gravit. Space Biol. Bull. 16 (2003) 29-36
23. Newell H., and Naugle J. Radiation environment in space. Science 132 (1960) 1465-1472
24. Ritter S., Nasonova E., Gudowska-Nowak E., Scholz M., and Kraft G. High-LET-induced chromosome aberrations in V79 cells analyzed in first and second post-irradiation metaphases. Int. J. Radiat. Biol. 76 (2000) 149-161
25. Rogakou E.P., Nieves-Neira W., Boon C., Pommier Y., and Bonner W.M. Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. J. Biol. Chem. 275 (2000) 9390-9395
26. Schimmerling W. Overview of NASA's space radiation research program. Gravit. Space Biol. Bull. 16 (2003) 5-10
27. Shao C., Furusawa Y., Aoki M., and Ando K. Role of gap junctional intercellular communication in radiation-induced bystander effects in human fibroblasts. Radiat. Res. 160 (2003) 318-323
28. Todd P., Schroy C., Attix F., and Theus R. Spatial distribution of human cell survival in a neutron bean designed for therapy. Cancer. 34 (1974) 33-38
29. Tsao C.H., Silberberg R., Barghouty A.F., and Sihver L. Energy degradation in cosmic-ray nuclear spallation reactions: relaxing the straight-ahead approximation. Ap. J. 451 (1995) 275
30. UPROP a heavy-ion propagation code, 1989. SCC Report, 1989, Severn Communications Corporation, 89-102.
31. Wilson J.W., Thibeault S.A., Cucinotta F.A., Shinn J.L., Kim M., Kiefer R., and Badavi F.F. Issues in protection from galactic cosmic rays. Radiat. Environ. Biophys. 34 (1995) 217-222
32. Wilson J.W., Tripathi R.K., Qualls G.D., Cucinotta F.A., Prael R.E., Norbury J.W., Heinbockel J.H., Tweed J., and De Angelis G. Advances in space radiation shielding codes. J. Radiat. Res. 43 (2002) S87-S91
33. Wu H., George K., Willingham V., Kawata T., and Cucinotta F.A. Comparison of F ratios generated from interphase and metaphase chromosome damage induced by high doses of low- and high-LET radiation. Radiat. Res. 155 (2001) 57-62