Utility of adenovirus-mediated Fas ligand and bcl-2 gene transfer to modulate rat liver allograft survival

Hepatobiliary and Pancreatic Diseases International

Volumn 5, Issue 4, 2006, Pages 505-510

  Wang, De Sheng ^a   Li, Yu ^b   Dou, Ke Feng ^a   Li, Kai Zong ^a   Song, Zhen Shun ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Bcl 2; Fas ligand; Immune tolerance; Liver transplantation

Indexed keywords

FAS LIGAND; MESSENGER RNA; PROTEIN BCL 2;

ADENOVIRUS VECTOR; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE TRANSFER; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; GRAFT RECIPIENT; GRAFT REJECTION; GRAFT SURVIVAL; HISTOPATHOLOGY; IMMUNE RESPONSE; LIVER GRAFT; LIVER PROTECTION; LIVER TRANSPLANTATION; MALE; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL TIME; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; FAS LIGAND PROTEIN; GENES, BCL-2; GRAFT REJECTION; LIVER; LIVER TRANSPLANTATION; MALE; RATS; RATS, INBRED LEW; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HOMOLOGOUS;

EID: 33751231064     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Griffith TS, Ferguson TA. The role of FasL-induced apoptosis in immune privilege. Immunol Today 1997;18: 240-244.
2. Bellgrau D, Gold D, Selawry H, Moore J, Franzusoff A, Duke RC. A role for CD95 ligand in preventing graft rejection. Nature 1995;377:630-632.
3. Boomer JS, Derks RA, Lee GW, DuChateau BK, Gilman-Sachs A, Beaman KD. Regeneration and tolerance factor is expressed during T-lymphocyte activation and plays a role in apoptosis. Hum Immunol 2001;62:577-588.
4. Chua HL, Serov Y, Brahmi Z. Regulation of FasL expression in natural killer cells. Hum Immunol 2004;65:317-327.
5. + T-cell-dependent immune damage of liver parenchymal cells is mediated by alloantibody. Transplantation 2005;80:514-521.
6. Wang X, DeFrances MC, Dai Y, Pediaditakis P, Johnson C, Bell A, et al. A mechanism of cell survival: sequestration of Fas by the HGF receptor Met. Mol Cell 2002;9:411-421.
7. Zender L, Hutker S, Liedtke C, Tillmann HL, Zender S, Mundt B, et al. Caspase 8 small interfering RNA prevents acute liver failure in mice. Proc Natl Acad Sci U S A 2003;100:7797-7802.
8. Schmitt CA, Lowe SW. Bcl-2 mediates chemoresistance in matched pairs of primary E(mu)-myc lymphomas in vivo. Blood Cells Mol Dis 2001;27:206-216.
9. Zucchini N, de Sousa G, Bailly-Maitre B, Gugenheim J, Bars R, Lemaire G, et al. Regulation of Bcl-2 and Bcl-xL anti-apoptotic protein expression by nuclear receptor PXR in primary cultures of human and rat hepatocytes. Biochim Biophys Acta 2005;1745:48-58.
10. Sutton VR, Vaux DL, Trapani JA. Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes. J Immunol 1997;158:5783-5790.
11. Thomenius MJ, Wang NS, Reineks EZ, Wang Z, Distelhorst CW. A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection. J Exp Med 1996;183:1031-1036.
12. Rao JN, Guo X, Liu L, Zou T, Murthy KS, Yuan JX, et al. Polyamines regulate Rho-kinase and myosin phosphorylation during intestinal epithelial restitution. Am J Physiol Cell Physiol 2003;284:C848-C859.
13. Zhang X, Brunner T, Carter L, Dutton RW, Rogers P, Bradley L, et al. Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J Exp Med 1997;185:1837-1849.
14. Kamada N, Calne RY. A surgical experience with five hundred thirty liver transplants in the rat. Surgery 1983;93:64-69.
15. Wang DS, Dou KF, Li KZ, Gao ZQ, Song ZS, Liu ZC. Hepatocellular apoptosis after hepatectomy in obstructive jaundice in rats. World J Gastroenterol 2003;9:2737-2741
16. Askenasy N, Yolcu ES, Yaniv I, Shirwan H. Induction of tolerance using Fas ligand: a double-edged immunomodulator. Blood 2005;105:1396-1404.
17. Askenasy N, Yolcu ES, Wang Z, Shirwan H. Display of Fas ligand protein on cardiac vasculature as a novel means of regulating allograft rejection. Circulation 2003;107:1525-1531.
18. Minagawa R, Okano S, Tomita Y, Kishihara K, Yamada H, Nomoto K, et al. The critical role of Fas-Fas ligand interaction in donor-specific transfusion-induced tolerance to H-Y antigen. Transplantation 2004;78:799-806.
19. Djamali A, Waller KR, McAnulty J, Hullett D, Becker BN, Odorico JS. Intrathymic injection of anti-Fas monoclonal antibody prolongs murine non-vascularized cardiac allograft survival. Transpl Int 2004;17:301-309.
20. Zhang HG, Su X, Liu D, Liu W, Yang P, Wang Z, et al. Induction of specific T cell tolerance by Fas ligand-expressing antigen-presenting cells. J Immunol 1999;162: 1423-1430.
21. Lau HT, Yu M, Fontana A, Stoeckert CJ Jr. Prevention of islet allograft rejection with engineered myoblasts expressing FasL in mice. Science 1996;273:109-112.
22. Ke B, Coito AJ, Kato H, Zhai Y, Wang T, Sawitzki B, et al. Fas ligand gene transfer prolongs rat renal allograft survival and down-regulates anti-apoptotic Bag-1 in parallel with enhanced Th2-type cytokine expression. Transplantation 2000;69:1690-1694.
23. Chervonsky AV, Wang Y, Wong FS, Visintin I, Flavell RA, Janeway CA Jr, et al. The role of Fas in autoimmune diabetes. Cell 1997;89:17-24.
24. Allison J, Georgiou HM, Strasser A, Vaux DL. Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts. Proc Natl Acad Sci U S A i997;94:3943-3947.
25. Wiedmann M, Tamaki S, Silberman R, de la Monte SM, Cousens L, Wands JR. Constitutive over-expression of the insulin receptor substrate-1 causes functional up-regulation of Fas receptor. J Hepatol 2003;38:803-810.
26. Li XK, Okuyama T, Tamura A, Enosawa S, Kaneda Y, Takahara S, et al. Prolonged survival of rat liver allografts transfected with Fas ligand-expressing plasmid. Transplantation 1998;66:1416-1423.
27. Zhang N, Hartig H, Dzhagalov I, Draper D, He YW. The role of apoptosis in the development and function of T lymphocytes. Cell Res 2005;15:749-769.
28. Sun K, Liu ZS, Sun Q. Role of mitochondria in cell apoptosis during hepatic ischemia-reperfusion injury and protective effect of ischemic postconditioning. World J Gastroenterol 2004;10:1934-1938.
29. Li SX, Gui N, Zhang CL, Zhao XL, Yu SF, Xie KQ. Effect of subchronic exposure to acrylamide induced on the expression of bcl-2, bax and caspase-3 in the rat nervous system. Toxicology 2006;217:46-53.
30. Shinoura N, Yoshida Y, Nishimura M, Muramatsu Y, Asai A, Kirino T, et al. Expression level of Bcl-2 determines anti- or proapoptotic function. Cancer Res 1999;59:4119-4128.
31. Wang J, Li W, Min J, Ou Q, Chen J, Song E. Intrasplenic transplantation of allogeneic hepatocytes modified by BCL-2 gene protects rats from acute liver failure. Transplant Proc 2004;36:2924-2926.