CD4+ T-cell-dependent immune damage of liver parenchymal cells is mediated by alloantibody

Transplantation

Volumn 80, Issue 4, 2005, Pages 514-521

  Horne, Phillip H ^a   Lunsford, Keri E ^a   Eiring, Anna M ^b   Wang, Yue ^b   Gao, Donghong ^b   Bumgardner, Ginny L ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

Author keywords

Alloantibody; B cells; CD4+ T cells; CD8+ T cells; FasL; Interferon ; Perforin

Indexed keywords

ALLOANTIBODY; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN G;

ACUTE GRAFT REJECTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; FLOW CYTOMETRY; GRAFT SURVIVAL; HEPATOCYTE TRANSPLANTATION; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; LIVER CELL; LIVER PARENCHYMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; SPLEEN CELL; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD4; ANTIGENS, CD8; APOPTOSIS; B-LYMPHOCYTES; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; FOLLOW-UP STUDIES; GRAFT REJECTION; GRAFT SURVIVAL; HEPATOCYTES; IMMUNITY, CELLULAR; IMMUNOHISTOCHEMISTRY; ISOANTIBODIES; LIVER TRANSPLANTATION; MICE; MICE, INBRED C57BL; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS;

EID: 23944431828     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.tp.0000168342.57948.68     Document Type: Article

References (32)

1. Trpkov K, Campbell P, Pazderka F, et al. Pathologic features of acute renal allograft rejection associated with donor-specific antibody, Analysis using the Banff grading schema. Transplantation 1996; 61(11): 1586.
2. Halloran PF, Schlaut J, Solez K, Srinivasa NS. The significance of the anti-class I response. II. Clinical and pathologic features of renal transplants with anti-class I-like antibody. Transplantation 1992; 53(3): 550.
3. Lobo PI, Spencer CE, Stevenson WC, Pruett TL. Evidence demonstrating poor kidney graft survival when acute rejections are associated with IgG donor-specific lymphocytotoxin. Transplantation 1995; 59(3): 357.
4. McKenna RM, Takemoto SK, Terasaki PI. Anti-HLA antibodies after solid organ transplantation. Transplantation 2000; 69(3): 319.
5. + T cell-mediated rejection of major histocompatibility complex class I-disparate grafts: a role for alloantibody. Eur J Immunol 1993; 23(9): 2078.
6. Wasowska BA, Qian Z, Cangello DL, et al. Passive transfer of alloantibodies restores acute cardiac rejection in IgKO mice. Transplantation 2001; 71(6): 727.
7. Brandie D, Joergensen J, Zenke G, et al. Contribution of donor-specific antibodies to acute allograft rejection: evidence from B cell-deficient mice. Transplantation 1998; 65(11): 1489.
8. + T-cell dependent antibody-mediated graft rejection. Immunol Today 1992; 13(11): 434.
9. Mauiyyedi S, Colvin RB. Humoral rejection in kidney transplantation: new concepts in diagnosis and treatment. Curr Opin Nephrol Hypertens 2002; 11 (6): 609.
10. Herzenberg AM, Gill JS, Djurdjev O, Magil AB. C4d deposition in acute rejection: an independent long-term prognostic factor. J Am Soc Nephrol 2002; 13(1): 234.
11. Regele H, Exner M, Watschinger B, et al. Endothelial C4d deposition is associated with inferior kidney allograft outcome independently of cellular rejection. Nephrol Dial Transplant 2001; 16(10): 2058.
12. Lederer SR, Kluth-Pepper B, Schneeberger H, et al. Impact of humoral alloreactivity early after transplantation on the long-term survival of renal allografts. Kidney Int 2001; 59(1): 334.
13. Duong Van Huyen JP, Fornes P, Guillemain R, et al. Acute vascular humoral rejection in a sensitized cardiac graft recipient: diagnostic value of C4d immunofluorescence. Hum Pathol 2004; 35(3): 385.
14. Magro CM, Pope Harman, A, et al. Use of C4d as a diagnostic adjunct in lung allograft biopsies. Am J Transplant 2003; 3(9): 1143.
15. + T-cell responses in acute rejection. Transplantation 1999; 68(4): 555.
16. Bumgardner GL, Gao D, Li J, et al. Rejection responses to allogeneic hepatocytes by reconstituted SCID mice, CD4 KO, and CD8 KO mice. Transplantation 2000; 70(12): 1771.
17. + cells that independently initiate rejection of allogeneic hepatocytes in mice. Hepatology 2000; 32(5): 1018.
18. Bumgardner GL, Li J, Heininger M, et al. In vivo immunogenicity of purified allogeneic hepatocytes in a murine hepatocyte transplant model. Transplantation 1998; 65(1): 47.
19. Bumgardner GL, Heininger M, Li J, et al. A functional model of hepatocyte transplantation for in vivo immunologic studies. Transplantation 1998; 65(1): 53.
20. Seglen PO. Preparation of rat liver parenchymal cells: enzymatic requirements for tissue dispersion. Exp. Cell Res 1973; 82: 391.
21. Seglen PO. Preparation of isolated rat liver cells. Methods Cell Biol 1976; 13: 30.
22. + T cells in the development of allospecific cytotoxicity in hepatocyte sponge matrix allografts. Transplantation 1992; 53(4): 857.
23. Wang Y, Gao D, Lunsford KE, et al. Targeting LFA-I synergizes with CD40/CD40L blockade for suppression of both CD4-dependent and CD8-dependent rejection. Am J Transplant 2003; 3(10): 1251.
24. Bumgardner GL, Orosz CG. Unusual patterns of alloimmunity evoked by allogeneic liver parenchymal cells. Immunol Rev 2000; 174: 260.
25. + T cell activation and tolerance induction in B cell knockout mice. J Exp Med 1996; 183(4): 1339.
26. Sunshine GH, Jimmo BL, Ianelli C, Jarvis L. Strong priming of T cells adoptively transferred in to seid mice. J Exp Med 1991; 174(6): 1653.
27. Ronchese F, Hausmann B. B lymphocytes in vivo fail to prime naive T cells but can stimulate antigen-experienced T lymphocytes. J Exp Med 1993; 177(3): 679.
28. + T cell activation. J Immunol 2000; 165(9): 4994.
29. Coudert JD, Coureau C, Guery JC. Preventing NK cell activation by donor dendritic cells enhances allospecific CD4 T cell priming and promotes Th type 2 responses to transplantation antigens. J Immunol 2002; 169(6): 2979.
30. Auchincloss Jr H, Ghobrial RR, Russell PS, Winn HJ. Prevention of alloantibody formation after skin grafting without prolongation of graft survival by anti-L3T4 in vivo. Transplantation 1988; 45(6): 1118.
31. Gao D, Lunsford KE, Eiring AM, Bumgardner GL. Critical role for CD8+ T cells in allograft acceptance induced by DST and CD40/CD154 costimulatory blockade. Am J Transplant 2004; 4(7): 1061.
32. Rahimi S, Qian Z, Layton J, et al. Non-complement- and complement-activating antibodies synergize to cause rejection of cardiac allografts. Am J Transplant 2004; 4(3): 326.