H-reflex depression by propofol and sevoflurane is dependent on stimulus intensity

Clinical Neurophysiology

Volumn 117, Issue 12, 2006, Pages 2653-2660

  Dincklage, Falk von ^a   Reiche, Josephine ^a   Rehberg, Benno ^a   Baars, Jan H ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Drug effects; H reflex; Motoneuron excitability; Propofol; Sevoflurane; Spinal cord reflexes

Indexed keywords

PROPOFOL; SEVOFLURANE;

ADULT; ARTICLE; DRUG EFFECT; FEMALE; FRIEDMAN TEST; HOFFMANN REFLEX; HUMAN; HUMAN EXPERIMENT; MALE; METHODOLOGY; MOTONEURON; NORMAL HUMAN; PRIORITY JOURNAL; STIMULUS RESPONSE; TIBIAL NERVE; VOLUNTEER;

ADULT; ANALYSIS OF VARIANCE; DIFFERENTIAL THRESHOLD; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTRIC STIMULATION; FEMALE; H-REFLEX; HUMANS; HYPNOTICS AND SEDATIVES; MALE; METHYL ETHERS; PROPOFOL; TIBIAL NERVE;

EID: 33751222553     PISSN: 13882457     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinph.2006.08.006     Document Type: Article

References (43)

1. Ashby P., Carlen P.L., MacLeod S., and Sinha P. Ethanol and spinal presynaptic inhibition in man. Ann. Neurol. 1 (1977) 478-480
2. Azouvi P., Roby-Brami A., Biraben A., Thiebaut J.B., Thurel C., and Bussel B. Effect of intrathecal baclofen on the monosynaptic reflex in humans: evidence for a postsynaptic action. J Neurol Neurosurg Psychiatry 56 (1993) 515-519
3. Baars J.H., Kalisch D., Herold K.F., Hadzidiakos D.A., and Rehberg B. Concentration-dependent suppression of F-waves by sevoflurane does not predict immobility to painful stimuli in humans. Br J Anaesth 95 (2005) 789-797
4. Baars J.H., Dangel C., Herold K.F., Hadzidiakos D.A., and Rehberg B. Suppression of the human spinal H-reflex by propofol: a quantitative analysis. Acta Anaesthesiol Scand 50 (2006) 193-200
5. Baars J.H., von D.F., Reiche J., and Rehberg B. Propofol increases presynaptic inhibition of ia afferents in the intact human spinal cord. Anesthesiology 104 (2006) 798-804
6. Chabal C., Jacobson L., and Little J. Effects of intrathecal fentanyl and lidocaine on somatosensory-evoked potentials, the H-reflex, and clinical responses. Anesth. Analg. 67 (1988) 509-513 JID-1310650
7. Chernik D.A., Gillings D., Laine H., Hendler J., Silver J.M., Davidson A.B., Schwam E.M., and Siegel J.L. Validity and reliability of the Observer's Assessment of Alertness/Sedation Scale: study with intravenous midazolam. J Clin Psychopharmacol 10 (1990) 244-251
8. Crayton J.W. The effect of diazepam on the spinal monosynaptic (H-) reflex in man. Neuropharmacology 19 (1980) 915-918
9. Crone C., Hultborn H., Jespersen B., and Nielsen J. Reciprocal Ia inhibition between ankle flexors and extensors in man. J Physiol 389 (1987) 163-185
10. Crone C., Hultborn H., Mazieres L., Morin C., Nielsen J., and Pierrot-Deseilligny E. Sensitivity of monosynaptic test reflexes to facilitation and inhibition as a function of the test reflex size: a study in man and the cat. Exp Brain Res 81 (1990) 35-45
11. Dachy B., and Dan B. Electrophysiological assessment of the effect of intrathecal baclofen in spastic children. Clin Neurophysiol 113 (2002) 336-340
12. Dachy B., and Dan B. Electrophysiological assessment of the effect of intrathecal baclofen in dystonic children. Clin Neurophysiol 115 (2004) 774-778
13. De Jong R.H., Hershey W.N., and Wagman I.H. Measurement of aspinal reflex response (H-reflex) during general anesthesia in man. Association between reflex depression and muscular relaxation. Anesthesiology 28 (1967) 382-389 JID-1300217
14. Eke-Okoro S.T. The H-reflex studied in the presence of alcohol, aspirin, caffeine, force and fatigue. Electromyogr Clin Neurophysiol 22 (1982) 579-589
15. Franks N.P., and Lieb W.R. Molecular and cellular mechanisms of general anaesthesia. Nature 367 (1994) 607-614
16. Funase K., Imanaka K., and Nishihira Y. Excitability of the soleus motoneuron pool revealed by the developmental slope of the H-reflex as reflex gain. Electromyogr Clin Neurophysiol 34 (1994) 477-489
17. Grasshoff C., and Antkowiak B. Propofol and sevoflurane depress spinal neurons in vitro via different molecular targets. Anesthesiology 101 (2004) 1167-1176
18. Grossi P., and Arner S. Effect of epidural morphine on the Hoffman-reflex in man. Acta Anaesthesiol Scand 28 (1984) 152-154 JID-0370270
19. Haftel V.K., Prather J.F., Heckman C J., and Cope T.C. Recruitment of cat motoneurons in the absence of homonymous afferent feedback. J Neurophysiol 86 (2001) 616-628
20. Henneman E. The size principle and its relation to transmission failure in Ia projections to spinal motoneurons. Ann N Y Acad Sci 627 (1991) 165-168
21. Hennings K., rendt-Nielsen L., and Andersen O.K. Orderly activation of human motor neurons using electrical ramp prepulses. Clin Neurophysiol 116 (2005) 597-604
22. Hirota K., and Roth S.H. Sevoflurane modulates both GABAA and GABAB receptors in area CA1 of rat hippocampus. Br J Anaesth 78 (1997) 60-65
23. Hirota K., Roth S.H., Fujimura J., Masuda A., and Ito Y. GABAergic mechanisms in the action of general anesthetics. Toxicol Lett 100-101 (1998) 203-207
24. Hultborn H., Meunier S., Morin C., and Pierrot-Deseilligny E. Assessing changes in presynaptic inhibition of I a fibres: a study in man and the cat. J Physiol 389 (1987) 729-756
25. Kammer T., Rehberg B., Menne D., Wartenberg H.C., Wenningmann I., and Urban B.W. Propofol and sevoflurane in subanesthetic concentrations act preferentially on the spinal cord: evidence from multimodal electrophysiological assessment. Anesthesiology 97 (2002) 1416-1425
26. Kerz T., Hennes H.J., Feve A., Decq P., Filipetti P., and Duvaldestin P. Effects of propofol on H-reflex in humans. Anesthesiology 94 (2001) 32-37
27. King B.S., and Rampil I.J. Anesthetic depression of spinal motor neurons may contribute to lack of movement in response to noxious stimuli. Anesthesiology 81 (1994) 1484-1492
28. Matute E., and Lopez-Garcia J.A. Characterisation of sevoflurane effects on spinal somato-motor nociceptive and non-nociceptive transmission in neonatal rat spinal cord: an electrophysiological study in vitro. Neuropharmacology 44 (2003) 811-816
29. Mendell L.M., and Henneman E. Terminals of single Ia fibers: location, density, and distribution within a pool of 300 homonymous motoneurons. J Neurophysiol 34 (1971) 171-187
30. Nance P.W., Shears A.H., and Nance D.M. Reflex changes induced by clonidine in spinal cord injured patients. Paraplegia 27 (1989) 296-301
31. Orsnes G., Crone C., Krarup C., Petersen N., and Nielsen J. The effect of baclofen on the transmission in spinal pathways in spastic multiple sclerosis patients. Clin Neurophysiol 111 (2000) 1372-1379
32. Pierrot-Deseilligny E., and Mazevet D. The monosynaptic reflex: a tool to investigate motor control in humans. Interest and limits. Neurophysiol Clin 30 (2000) 67-80
33. Ragnarson B., Ornung G., Grant G., Ottersen O.P., and Ulfhake B. Glutamate and AMPA receptor immunoreactivity in Ia synapses with motoneurons and neurons of the central cervical nucleus. Exp Brain Res 149 (2003) 447-457
34. Rehberg B., Grunewald M., Baars J., Fuegener K., Urban B.W., and Kox W.J. Monitoring of immobility to noxious stimulation during sevoflurane anesthesia using the spinal H-reflex. Anesthesiology 100 (2004) 44-50
35. Remy-Neris O., Barbeau H., Daniel O., Boiteau F., and Bussel B. Effects of intrathecal clonidine injection on spinal reflexes and human locomotion in incomplete paraplegic subjects. Exp Brain Res 129 (1999) 433-440
36. Roby A., Bussel B., and Willer J.C. Morphine reinforces post-discharge inhibition of alpha-motoneurons in man. Brain Res 222 (1981) 209-212
37. Schieppati M. The Hoffmann reflex: a means of assessing spinal reflex excitability and its descending control in man. Prog Neurobiol 28 (1987) 345-376
38. Schnider T.W., Minto C.F., Gambus P.L., Andresen C., Goodale D.B., Shafer S.L., and Youngs E.J. The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers. Anesthesiology 88 (1998) 1170-1182
39. Somjen G., Carpenter D., and Henneman E. Selective depression of alpha motoneurons of small size by ether. J Pharmacol Exp Ther 148 (1965) 380-385
40. Somjen G., Carpenter D.O., and Henneman E. Responses of motoneurons of different sizes to graded stimulation of supraspinal centers of the brain. J Neurophysiol 28 (1965) 958-965
41. Soriano S.G., Logigian E.L., Scott R.M., Prahl P.A., and Madsen J.R. Nitrous oxide depresses the H-reflex in children with cerebral palsy. Anesth Analg 80 (1995) 239-241
42. Walton C., Kalmar J., and Cafarelli E. Caffeine increases spinal excitability in humans. Muscle Nerve 28 (2003) 359-364
43. Zhou H.H., Mehta M., and Leis A.A. Spinal cord motoneuron excitability during isoflurane and nitrous oxide anesthesia. Anesthesiology 86 (1997) 302-307