-
1
-
-
0035338343
-
Risks in new drug development: Approval success rates for investigational drugs
-
DiMasi J.A. Risks in new drug development: approval success rates for investigational drugs. Clin. Pharmacol. Ther. 69:2001;297-307
-
(2001)
Clin. Pharmacol. Ther.
, vol.69
, pp. 297-307
-
-
Dimasi, J.A.1
-
2
-
-
0036441844
-
The value of improving the productivity of the drug development process: Faster times and better decisions
-
DiMasi J.A. The value of improving the productivity of the drug development process: faster times and better decisions. Pharmacoeconomics. 20:(Suppl. 3):2002;1-10
-
(2002)
Pharmacoeconomics
, vol.20
, Issue.SUPPL. 3
, pp. 1-10
-
-
Dimasi, J.A.1
-
3
-
-
0031003468
-
Learning versus confirming in clinical drug development
-
Sheiner L.B. Learning versus confirming in clinical drug development. Clin. Pharmacol. Ther. 61:1997;275-291
-
(1997)
Clin. Pharmacol. Ther.
, vol.61
, pp. 275-291
-
-
Sheiner, L.B.1
-
4
-
-
0034119297
-
Pharmacokinetic/pharmacodynamic modeling in drug development
-
Sheiner L.B., Steimer J.L. Pharmacokinetic/pharmacodynamic modeling in drug development. Annu. Rev. Pharmacol. Toxicol. 40:2000;67-95
-
(2000)
Annu. Rev. Pharmacol. Toxicol.
, vol.40
, pp. 67-95
-
-
Sheiner, L.B.1
Steimer, J.L.2
-
5
-
-
0042326191
-
New approaches to drug discovery and development: A mechanism-based approach to pharmaceutical research and its application to BNP7787, a novel chemoprotective agent
-
Hausheer F.H., et al. New approaches to drug discovery and development: a mechanism-based approach to pharmaceutical research and its application to BNP7787, a novel chemoprotective agent. Cancer Chemother. Pharmacol. 52:(Suppl. 1):2003;S3-S15
-
(2003)
Cancer Chemother. Pharmacol.
, vol.52
, Issue.SUPPL. 1
-
-
Hausheer, F.H.1
-
6
-
-
4644327461
-
Finding value in in silico biology
-
Bangs A., Paterson T. Finding value in in silico biology. Biosilico. 1:2003;18-22
-
(2003)
Biosilico
, vol.1
, pp. 18-22
-
-
Bangs, A.1
Paterson, T.2
-
7
-
-
4644319546
-
Assessing the impact of biosimulation on target selection and validation
-
Scherrer D., et al. Assessing the impact of biosimulation on target selection and validation. Biosilico. 1:2003;184-188
-
(2003)
Biosilico
, vol.1
, pp. 184-188
-
-
Scherrer, D.1
-
9
-
-
34248680469
-
Physiologically based pharmacokinetics in drug development and regulatory science: A workshop report
-
Article 6
-
Rowland, M. et al (2004). Physiologically based pharmacokinetics in drug development and regulatory science: A workshop report. AAPS PharmSci. 6, Article 6 (http://www.aapspharmsci.org/ps0601/ps060106/ps060106.pdf)
-
(2004)
AAPS PharmSci.
, vol.6
-
-
Rowland, M.1
-
11
-
-
4644327462
-
The virtual patient: Capturing patient variability using biosimulation
-
Michelson S., Okino M. The virtual patient: capturing patient variability using biosimulation. Preclinica. 2:2004;33-37
-
(2004)
Preclinica
, vol.2
, pp. 33-37
-
-
Michelson, S.1
Okino, M.2
-
12
-
-
0141762330
-
Biomarkers, validation and pharmacokinetic-pharmacodynamic modeling
-
Colburn W.A., Lee J.W. Biomarkers, validation and pharmacokinetic- pharmacodynamic modeling. Clin. Pharmacokinet. 42:2003;997-1022
-
(2003)
Clin. Pharmacokinet
, vol.42
, pp. 997-1022
-
-
Colburn, W.A.1
Lee, J.W.2
-
13
-
-
0036399227
-
Biomarkers and surrogate endpoints: How and when might they impact drug development?
-
Lathia C.D. Biomarkers and surrogate endpoints: how and when might they impact drug development? Dis. Markers. 18:2002;83-90
-
(2002)
Dis. Markers
, vol.18
, pp. 83-90
-
-
Lathia, C.D.1
|