Steric effects in release of amides from linkers in solid-phase synthesis. Molecular mechanics modeling of key step in peptide and combinatorial chemistry

International Journal of Peptide Research and Therapeutics

Volumn 12, Issue 4, 2006, Pages 335-339

  Norrby, Per Ola ^a   Jensen, Knud J ^b  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b KVL   (Denmark)

Author keywords

Backbone amide linker; BAL; Peptide; Solid phase synthesis

Indexed keywords

AMIDE; AMINO ACID; FUNCTIONAL GROUP; PEPTIDE;

ACIDITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMBINATORIAL CHEMISTRY; EQUILIBRIUM CONSTANT; MOLECULAR MECHANICS; MOLECULAR MODEL; PEPTIDE SYNTHESIS; PREDICTION; PROTEIN DEGRADATION; PROTEIN SECRETION; PROTEIN STABILITY; SOLID PHASE SYNTHESIS; STEREOCHEMISTRY; STEREOSPECIFICITY;

EID: 33751195733     PISSN: 15733149     EISSN: 15733904     Source Type: Journal    
DOI: 10.1007/s10989-006-9036-1     Document Type: Article

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