Inhalation of human insulin is associated with improved insulin action compared with subcutaneous injection and endogenous secretion in dogs

Journal of Pharmacology and Experimental Therapeutics

Volumn 319, Issue 3, 2006, Pages 1258-1264

  Edgerton, Dale S ^a,e   Stettler, Kathryn M ^a   Neal, Doss W ^a   Scott, Melanie ^a   Bowen, Larry ^b   Wilson, Warren ^b   Hobbs, Charles H ^b   Leach, Chet ^c   Strack, Thomas R ^d   Cherrington, Alan D ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^c NEKTAR THERAPEUTICS   (United States)

^d PFIZER INC   (United States)

^e VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLUCAGON; GLUCOSE; HUMAN INSULIN; INSULIN; SOMATOSTATIN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG MIXTURE; GLUCOSE TRANSPORT; INSULIN SENSITIVITY; MALE; NONHUMAN; PRIORITY JOURNAL;

ADMINISTRATION, INHALATION; ANIMALS; AREA UNDER CURVE; BLOOD GLUCOSE; C-PEPTIDE; DATA INTERPRETATION, STATISTICAL; DOGS; HYPOGLYCEMIC AGENTS; INJECTIONS, SUBCUTANEOUS; INSULIN; INSULIN RESISTANCE; MALE;

EID: 33751194897     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.108373     Document Type: Article

References (23)

1. Abumrad NN, Cherrington AD, Williams PE, Lacy WW, and Rabin D (1982) Absorption and disposition of a glucose load in the conscious dog. Am J Physiol 242:E398-E406.
2. Ader M and Bergman RN (1990) Peripheral effects of insulin dominate suppression of fasting hepatic glucose production. Am J Physiol 258:E1020-E1032.
3. Barrett EJ, Ferrannini E, Gusberg R, Bevilacqua S, and DeFronzo RA (1985) Hepatic and extrahepatic splanchnic glucose metabolism in the postabsorptive and glucose fed dog. Metabolism 34:410-420.
4. Bergman RN, Beir JR, and Hourigan PM (1982) (1982) Intraportal glucose infusion matched to oral glucose absorption: lack of evidence for "gut factor" involvement in hepatic glucose storage. Diabetes 31:27-35.
5. Cherrington AD (1999) Banting Lecture 1997: control of glucose uptake and release by the liver in vivo. Diabetes 48:1198-1214.
6. Cherrington AD, Neal DW, Edgerton DS, Glass D, Bowen L, Hobbs CH, Leach C, Rosskamp R, and Strack TR (2004) Inhalation of insulin in dogs: assessment of insulin levels and comparison to subcutaneous injection. Diabetes 53:877-881.
7. Damas J, Garbacki N, and Lefebvre PJ (2004) The kallikrein-kinin system, angiotensin converting enzyme inhibitors and insulin sensitivity. Diabetes Metab Res Rev 20:288-297.
8. Edgerton DS, Cardin S, Emshwiller M, Neal D, Chandramouli V, Schumann WC, Landau BR, Rossetti L, and Cherrington AD (2001) Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism. Diabetes 50:1872-1882.
9. Edgerton DS, Neal DW, Scott M, Bowen L, Wilson W, Hobbs CH, Leach C, Sivakumaran S, Strack TR, and Cherrington AD (2005) Inhalation of insulin (Exubera) is associated with augmented disposal of portally infused glucose in dogs. Diabetes 54:1164-1170.
10. Erman A, Chen-Gal B, David I, Giler S, Boner G, and van Dijk DJ (1998) Insulin treatment reduces the increased serum and lung angiotensin converting enzyme activity in streptozotocin-induced diabetic rats. Scand J Clin Lab Investig 58:81-87.
11. Fery F, Tappy L, Schneiter P, Deviere J, and Balasse EO (2005) Effect of somatostatin on duodenal glucose absorption in man. J Clin Endocrinol Metab 90:4163-4169.
12. Garg S, Rosenstock J, Silverman BL, Sun B, Konkoy CS, de la Pena A, and Muchmore DB (2006) Efficacy and safety of preprandial human insulin inhalation powder versus injectable insulin in patients with type 1 diabetes. Diabetologia 49:891-899.
13. Henriksen EJ and Jacob S (2003) Modulation of metabolic control by angiotensin converting enzyme (ACE) inhibition. J Cell Physiol 196:171-179.
14. Henriksen EJ, Jacob S, Kinnick TR, Teachey MK, and Krekler M (2001) Selective angiotensin II receptor receptor antagonism reduces insulin resistance in obese Zucker rats. Hypertension 38:884-890.
15. Hermansen K, Ronnemaa T, Petersen AH, Bellaire S, and Adamson U (2004) Intensive therapy with inhaled insulin via the AERx insulin diabetes management system. Diabetes Care 27:162-167.
16. Hollander PA, Blonde L, Rowe R, Mehta AE, Milburn JL, Hershon KS, Chiasson JL, and Levin SR (2004) Efficacy and safety of inhaled insulin (Exubera) compared with subcutaneous insulin therapy in patients with type 2 diabetes: results of a 6-month, randomized, comparative trial. Diabetes Care 27:2356-2362.
17. Jandeleit-Dahm KA, Tikellis C, Reid CM, Johnston CI, and Cooper ME (2005) Why blockade of the renin-angiotensin system reduces the incidence of new-onset diabetes. J Hypertens 23:463-473.
18. Krulewitz AH, Baur WE, and Fanburg BL (1984) Hormonal influence on endothelial cell angiotensin-converting enzyme activity. Am J Physiol 247:C163-C168.
19. Moore MC, Cherrington AD, Cline G, Pagliassotti MJ, Jones EM, Neal DW, Badet C, and Shulman GI (1991) Sources of carbon for hepatic glycogen synthesis in the conscious dog. J Clin Investig 88:578-587.
20. Quattrin T, Belanger A, Bohannon NJ, and Schwartz SL (2004) Efficacy and safety of inhaled insulin (Exubera) compared with subcutaneous insulin therapy in patients with type 1 diabetes: results of a 6-month, randomized, comparative trial. Diabetes Care 27:2622-2627.
21. Sharifi AM, Mousavi SH, and Larijani B (2004) Study of interaction between nitric oxide and ACE activity in STZ-induced diabetic rats: role of insulin. Pharmacol Res 50:261-266.
22. Sindelar DK, Balcom JH, Chu CA, Neal DW, and Cherrington AD (1996) A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog. Diabetes 45:1594-1604.
23. Skyler JS, Weinstock RS, Raskin P, Yale JF, Barrett E, Gerich JE, and Gerstein HC (2005) Use of inhaled insulin in a basal/bolus insulin regimen in type 1 diabetic subjects: a 6-month, randomized, comparative trial. Diabetes Care 28:1630-1635.