Inhalation of insulin (Exubera) is associated with augmented disposal of portally infused glucose in dogs

Diabetes

Volumn 54, Issue 4, 2005, Pages 1164-1170

  Edgerton, Dale S ^a   Neal, Doss W ^a   Scott, Melanie ^a   Bowen, Larry ^b   Wilson, Warren ^b   Hobbs, Charles H ^b   Leach, Chet ^b   Sivakumaran, Shantha ^c   Strack, Thomas R ^d   Cherrington, Alan D ^a,e  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^c SANOFI   (France)

^d PFIZER INC   (United States)

^e VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HUMAN INSULIN; INSULIN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTERIAL BLOOD; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DIABETES CONTROL; DOG; DRUG ADMINISTRATION ROUTE; DRUG EFFECT; DRUG MECHANISM; GLUCOSE BLOOD LEVEL; GLUCOSE INFUSION; GLUCOSE TRANSPORT; INFERIOR CAVA VEIN; INSULIN BLOOD LEVEL; INSULIN INFUSION; INTRAVENOUS GLUCOSE TOLERANCE TEST; MALE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL;

ADMINISTRATION, INHALATION; ANIMALS; BLOOD GLUCOSE; DOGS; GLUCOSE; INFUSIONS, INTRAVENOUS; INSULIN; MALE; PORTAL VEIN; VENA CAVA, INFERIOR;

EID: 20144389540     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.54.4.1164     Document Type: Article

References (30)

1. Skyler J: Efficacy and safety of inhaled insulin (Exubera) compared to subcutaneous insulin therapy in an intensive insulin regimen in patients with type 1 diabetes: results of a 6-month, randomized, comparative trial (Abstract). Diabetes 51:(Suppl. 2):A134, 2002
2. Cherrington AD, Neal DW, Edgerton DS, Glass D, Bowen L, Hobbs CH, Leach C, Rosskamp R, Strack TR: Inhalation of insulin in dogs: assessment of insulin levels and comparison to subcutaneous injection. Diabetes 53:877-881, 2004
3. Edgerton DS, Cardin S, Emshwiller M, Neal D, Chandramouli V, Schumann WC, Landau BR, Rossetti L, Cherrington AD: Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism. Diabetes 50:1872-1882, 2001
4. Moore MC, Cherrington AD, Cline G, Pagliassotti MJ, Jones EM, Neal DW, Badet C, Shulman GI: Sources of carbon for hepatic glycogen synthesis in the conscious dog. J Clin Invest 88:578-587, 1991
5. Moore MC, Hsieh PS, Neal DW, Cherrington AD: Nonhepatic response to portal glucose delivery in conscious dogs. Am J Physiol 279: E1271-E1277, 2000
6. Donmoyer CM, Chen SS, Hande SA, Lacy DB, Ejiofor J, McGuinness OP: Hyperinsulinemia compensates for infection-induced impairment in net hepatic glucose uptake during TPN. Am J Physiol 279:E235-E243, 2000
7. Galassetti P, Koyama Y, Coker RH, Lacy DB, Cherrington AD, Wasserman DH: Role of a negative arterial-portal venous glucose gradient in the postexercise state. Am J Physiol 277:E1038-E1045, 1999
8. Hsieh PS, Moore MC, Neal DW, Emshwiller M, Cherrington AD: Rapid reversal of the effects of the portal signal under hyperinsulinemic conditions in the conscious dog. Am J Physiol 276:E930-E937, 1999
9. Hellerstein MK: De novo lipogenesis in humans: metabolic and regulatory aspects. Eur J Clin Nutr 53 (Suppl 1):S53-S65, 1999
10. Laybutt DR, Chisholm DJ, Kraegen EW: Specific adaptations in muscle and adipose tissue in response to chronic systemic glucose oversupply in rats. Am J Physiol 273:E1-E9, 1997
11. Growdon WA, Bratton TS, Houston MC, Tarpley HL, Regen DM: Brain glucose metabolism in the intact mouse. Am J Physiol 221:1738-1745, 1971
12. Heinemann L: Alternative delivery routes: inhaled insulin. Diabetes Nutr Metab 15:417-422, 2002
13. Cook S, Scherrer U: Insulin resistance, a new target for nitric oxide-delivery drugs. Fundam Clin Pharmacol 16:441-453, 2002
14. Higaki Y, Hirshman MF, Fujii N, Goodyear LJ: Nitric oxide increases glucose uptake through a mechanism that is distinct from the insulin and contraction pathways in rat skeletal muscle. Diabetes 50:241-247, 2001
15. Ding Y, Vaziri ND, Coulson R, Kamanna VS, Roh DD: Effects of simulated hyperglycemia, insulin, and glucagon on endothelial nitric oxide synthase expression. Am J Physiol 279:E11-E17, 2000
16. Guazzi M, Brambilla R, De Vita S, Guazzi MD: Diabetes worsens pulmonary diffusion in heart failure, and insulin counteracts this effect. Am J Respir Crit Care Med 166:978-982, 2002
17. Schechter AN, Gladwin MT, Cannon RO 3rd: NO solutions? J Clin Invest 109:1149-1151, 2002
18. Schechter AN, Gladwin MT: Hemoglobin and the paracrine and endocrine functions of nitric oxide. N Engl J Med 348:1483-1485, 2003
19. Lautt WW: A new paradigm for diabetes and obesity: the hepatic insulin sensitizing substance (HISS) hypothesis. J Pharmacol Sci 95:9-17, 2004
20. Guarino MP, Afonso RA, Raimundo N, Raposo JF, Macedo MP: Hepatic glutathione and nitric oxide are critical for hepatic insulin-sensitizing substance action. Am J Physiol 284:6588-6594, 2003
21. Moore MC, Satake S, Baranowski B, Hsieh PS, Neal DW, Cherrington AD: Effect of hepatic denervation on peripheral insulin sensitivity in conscious dogs. Am J Physiol 282:E286-E296, 2002
22. Lautt WW, Macedo MP, Sadri P, Takayama S, Duarte Ramos F, Legare DJ: Hepatic parasympathetic (HISS) control of insulin sensitivity determined by feeding and fasting. Am J Physiol 281:G29-G36, 2001
23. Brooks GA, Butterfield GE, Wolfe RR, Groves BM, Mazzeo RS, Sutton JR, Wolfel EE, Reeves JT: Increased dependence on blood glucose after acclimatization to 4,300 m. J Appl Physiol 70:919-927, 1991
24. Krampl E, Kametas NA, Nowotny P, Roden M, Nicolaides KH: Glucose metabolism in pregnancy at high altitude. Diabetes Care 24:817-822, 2001
25. Prabhakar NR: NO and CO as second messengers in oxygen sensing in the carotid body. Respir Physiol 115:161-168, 1999
26. Lopez-Barneo J: Oxygen and glucose sensing by carotid body glomus cells. Curr Opin Neurobiol 13:493-499, 2003
27. Koyama Y, Coker RH, Stone EE, Lacy DB, Jabbour K, Williams PE, Wasserman DH: Evidence that carotid bodies play an important role in glucoregulation in vivo. Diabetes 49:1434-1442, 2000
28. Meszaros K, Lang CH, Bagby GJ, Spitzer JJ: Contribution of different organs to increased glucose consumption after endotoxin administration. J Biol Chem 262:10965-10970, 1987
29. Lang CH, Dobrescu C, Meszaros K: Insulin-mediated glucose uptake by individual tissues during sepsis. Metabolism 39:1096-1107, 1990
30. Kraegen EW, James DE, Jenkins AB, Chisholm DJ: Dose-response curves for in vivo insulin sensitivity in individual tissues in rats. Am J Physiol 248:E353-E362, 1985