Facilitation of cardiac vagal activity by CRF-R1 antagonists during swim stress in rats

Neuropsychopharmacology

Volumn 31, Issue 12, 2006, Pages 2580-2590

  Wood, Susan K ^a   Verhoeven, Robert E ^a   Savit, Aaron Z ^b   Rice, Kenner C ^c   Fischbach, Peter S ^a   Woods, James H ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b EARLHAM COLLEGE   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Antalarmin; Astressin B; Cardiac vagal activity; CRF antagonists; R121919; Swim stress

Indexed keywords

3 (6 DIMETHYLAMINO 4 METHYL 3 PYRIDINYL) 7 DIPROPYLAMINO 2,5 DIMETHYLPYRAZOLO[1,5 A]PYRIMIDINE; ANTALARMIN; ASTRESSIN; ATROPINE METHYL NITRATE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; GLUCOCORTICOID RECEPTOR ANTAGONIST; MIFEPRISTONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY TEMPERATURE; BRADYCARDIA; CONTROLLED STUDY; CORRELATION ANALYSIS; FORCED SWIMMING TEST; HEART FUNCTION; HEART RATE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHERMIA; IMMOBILIZATION; MALE; MENTAL STRESS; NEGATIVE FEEDBACK; NERVE POTENTIAL; NONHUMAN; PR INTERVAL; PRIORITY JOURNAL; RAT; VAGUS NERVE STIMULATION;

ANIMALS; BRADYCARDIA; CHOLINERGIC ANTAGONISTS; CORTICOTROPIN-RELEASING HORMONE; DEATH, SUDDEN, CARDIAC; DISEASE MODELS, ANIMAL; EXERCISE TOLERANCE; FATIGUE; HEART RATE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; HYPOTHERMIA, INDUCED; MALE; MIFEPRISTONE; PEPTIDE FRAGMENTS; PSYCHOMOTOR AGITATION; PYRIMIDINES; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRESS, PSYCHOLOGICAL; SWIMMING; VAGUS NERVE; VAGUS NERVE DISEASES;

EID: 33751080599     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1301085     Document Type: Article

References (51)

1. Agelink MW, Boz C, Ullrich H, Andrich J (2002). Relationship between major depression and heart rate variability. Clinical consequences and implication for antidepressive treatment. Psych Res 113: 139-149.
2. Angrilli A, Sarlo M, Palomba D, Schincaglia M, Stegagno L (1997). Respiratory sinus arrhythmia in blood phobic subjects. Percept Mot Skills 84: 505-506.
3. Baker MA, Horvath SM (1964). Influence of water temperature on heart rate and rectal temperature of swimming rats. Am J Physiol 207: 1073-1076.
4. Briscoe RJ, Cabrera CL, Baird TJ, Rice KC, Woods JH (2000). Antalarmin blockade of corticotropin releasing hormone-induced hypertension in rats. Brain Res 881: 204-207.
5. Buchheit M, Richard R, Doutreleau S, Lonsdorfer-Wolf E, Brandenberger G, Simon C (2004). Effect of acute hypoxia on heart rate variability at rest and during exercise. Int J Sports Med 25: 264-269.
6. Castro JL, Ricci D, Taira CA, Ramirez A (1999). Central benzodiazepine involvement in clonidine cardiovascular actions. Can J Physiol Pharmacol 77: 844-851.
7. 1 receptor mRNA expression. J Neurosci 15: 6340-6350.
8. Chalmers DT, Lovenberg TW, Grigoriadis DE, Behan DP, De Souza EB (1996). Corticotropin-releasing factor receptors: from molecular biology to drug design. Trends Pharmacol Sci 17: 166-172.
9. Cook CJ (2002). Glucocorticoid feedback increases the sensitivity of the limbic system to stress. Phys Behav 75: 755-764.
10. Dal-Zotto S, Marti O, Armario A (2003). Glucocorticoids are involved in the long-term effects of a single immobilization stress on the hypothalamic-pituitary-adrenal axis. Psychoneuroendocrinology 28: 992-1009.
11. Das G, Talmers FN, Weissler AM (1975). New observations of the effects of atropine on the sinoatrial and atrioventricular nodes in man. Am J Cardiol 36: 281-285.
12. Dawson CA, Nadel ER, Horvath SM (1968). Cardiac output in the cold-stressed swimming rat. Am J Physiol 214: 320-325.
13. Deak T, Nguyen KT, Ehrlich AL, Watkins LR, Spencer RL, Maier SF et al (1999). The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress. J Endocrinol 140: 79-86.
14. Detke MJ, Rickels M, Lucki I (1995). Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. J Psychopharmacol 121: 66-72.
15. Fisher LA (1989). Central autonomic modulation of cardiac baroreflex by corticotropin-releasing factor. Am J Physiol 256: H949-H955.
16. Friedman BH, Thayer JF, Borkovec TD, Tyrrell RA, Johnson BH, Columbo R (1993). Autonomic characteristics of nonclinical panic and blood phobia. Biol Psychiatry 34: 293-310.
17. Gardiner SM, March JE, Kemp PA, Davenport AP, Wiley KI, Bennett T (2005). Regional hemodynamic actions of selective corticotropin-releasing factor type 2 receptor ligands in conscious rats. J Pharmacol Exp Ther 312: 53-60.
18. Hartel G (1987). Psychological factors in cardiac arrhythmias. Ann Clin Res 19: 104-109.
19. Heinrichs SC, De Souza EB, Schulteis G, Lapsansky JL, Grigoriadis DE (2002). Brain penetrance, receptor occupancy and antistress in vivo efficacy of a small molecule corticotropin releasing factor type I receptor selective antagonist. Neuropsychopharmacology 27: 194-202.
20. Hood WB, Murray RH, Urschel CW, Bowers JA, Goldman J (1968). Circulatory effects of water immersion upon human subjects. Aerosp Med 39: 579-584.
21. Hsin LW, Tian X, Webster EL, Coop A, Caldwell TM, Jacobson AE et al (2002). CRHR1 receptor binding and lipophilicity of pyrrolopyrimidines, potential nonpeptide corticotropin-releasing hormone type 1 receptor antagonists. Bioorg Med Chem 10: 175-183.
22. Johnsen BH, Thayer JF, Laberg JC, Wormnes B, Raadal M, Skaret E et al (2003). Attentional and physiological characteristics of patients with dental anxiety. Anxiety Disord 17: 75-87.
23. Jutkiewicz EM, Wood SK, Houshyar H, Hsin LW, Rice KC, Woods JH (2005). The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919 in the forced swim test and on swim-induced increases in adrenocorticotropin in rats. J Psychopharmacol 180: 215-223.
24. Kawachi I, Colditz GA, Ascherio A, Rimm EB, Giovannucci E, Stampher MJ et al (1994). Prospective study of phobic anxiety and risk of coronary heart disease in men. Circulation 89: 1992-1997.
25. Kinoshita S, Konishi G (1989). Mechanisms of atypical atrioventricular Wenckelbach periodicity. A theroretical model derived from the concepts of inhomogeneous excitability and electrotonically mediated conduction. J Electrocardiol 22: 227-233.
26. Kosoyan HP, Wei JY, Tache Y (1999). Intracisternal sauvagine is more potent than corticotropin-releasing factor to decrease gastric vagal efferent activity in rats. Peptides 20: 851-858.
27. Levy MN, Zieske H (1969). Autonomic control of cardiac pacemaker activity and atrioventricular transmission. J App Physiol 27: 465-470.
28. 2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues. J Endocrinol 136: 4139-4142.
29. 2 receptors on cardiovascular function in the rat. Eur J Pharmacol 469: 111-115.
30. Miwa C, Sugiyama Y, Mano T, Iwase S, Matsukawa T (1997). Sympatho-vagal responses in humans to thermoneutral head-out water immersion. Aviat Space Enivron Med 68: 1109-1114.
31. Nahshoni E, Gur S, Marom S, Levin JB, Weizman A, Hermesh H (2004). QT dispersion in patients with social phobia. J Affect Disord 78: 21-26.
32. Negrao CE, Moreira ED, Brum PC, Denadai ML, Krieger EM (1992). Vagal and sympathetic control of heart rate during exercise by sedentary and exercise trained rats. Braz J Med Biol Res 25: 1045-1052.
33. Nijsen MJMA, Croiset G, Diamant M, Stam R, Kamphuis PJGH, Bruijnzeel A et al (2000). Endogenous corticotropin-releasing hormone inhibits conditioned fear-induced vagal activation in the rat. Eur J Pharmacol 389: 89-98.
34. Nishimura H, Tsuda A, Oguchi M, Ida Y, Tanaka M (1988). Is immobility in the forced swim test 'behavioral despair?'. Physiol Behav 42: 93-95.
35. Overton J, Fisher L (1991). Differentiated hemodynamic responses to central versus peripheral administration of corticotropin-releasing factor in conscious rats. J Autonom Nerv Syst 35: 43-52.
36. Paxinos G, Watson C (1982). The Rat Brain in Stereotaxic Coordinates. Academic Press: New York.
37. Perlstein I, Stepensky D, Krzyzanski W, Hoffman A (2002). A signal transduction pharmacodynamic model of the kinetics of the parasympathomimetic activity of low-dose scopolamine and atropine in rats. J Pharm Sci 92: 2500-2510.
38. Richter CP (1957). On the phenomenon of sudden death in animals and man. J Psychosom Med 19: 191-197.
39. Richter RM, Mulvany MJ (1995). Comparison of hCRF and oCRF effects on cardiovascular responses after central, peripheral, and in vitro application. Peptides 16: 843-849.
40. Rivier CL, Grigoriadis DE, Rivier JE (2003). Role of corticotropin- releasing factor receptors type 1 and 2 in modulating the rat adrenocorticotropin response to stressors. J Endocrinol 144: 2396-2403.
41. Rivier JE, Kirby DA, Lahrichi SL, Corrigan A, Vale WW (1999). Constrained corticotrophin releasing factor (CRF) antagonists (astressin analogues) with long duration of action in the rat. J Med Chem 42: 3175-3182.
42. Schipke JD, Pelzer M (2001). Effect of immersion, submersion, and scuba diving on heart rate variability. Br J Sports Med 35: 174-180.
43. Sgoifo A, Koolhaas JM, Musso E, De Boer SF (1999). Different sympathovagal modulation of heart rate during social and nonsocial stress episodes in wild-type rats. Phys Behav 67: 733-738.
44. Smith RF, Stanton K, Stoop D, Janusz W, King PH (1976). Quantitative electrocardiography during extended space flight: the second manned skylab mission. Aviat Space Environ Med 47: 353-359.
45. Wang L, Cardin S, Martinez V, Tache Y (1996). Intracerebroventricular CRF inhibits cold restraint-induced c-fos expression in the dorsal motor nucleus of the vagus and gastric erosions in rats. Brain Res 736: 44-53.
46. Watkins LL, Grossman P, Krishnan R, Sherwood A (1998). Anxiety and vagal control of heart rate. J Psychosom Med 60: 498-502.
47. Webster EL, Lewis DB, Torpy DJ, Zachman EK, Rice KC, Chrousos GP (1996). In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation. J Endocrinol 137: 5747-5750.
48. Wiersma A, Bohus B, Koolhaas JM (1993). Corticotropin-releasing hormone microinfusion in the central amygdala diminishes a cardiac parasympathetic outflow under stress-free conditions. Brain Res 625: 219-227.
49. Wittstein IS, Thiemann DR, Lima JAC, Baughman KL, Schulman SP, Gerstenblith G et al (2005). Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 352: 539-548.
50. Yeragani VK, Rao KA, Pohl R, Jampala VC, Balon R (2001). Heart rate and QT variability in children with anxiety disorders: A preliminary report. Depress Anxiety 13: 72-77.
51. Yeragani VK, Rao KA, Smitha M, Pohl RB, Balon R, Srinivasan K (2002). Diminished chaos of heart rate time series in patients with major depression. Biol Psychiatry 51: 733-744.