Carbon monoxide and pancreatic islet blood flow in the rat: Inhibition of haem oxygenase does not affect islet blood perfusion

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 66, Issue 7, 2006, Pages 543-548

  Carlsson, P O ^a   Bodin, B ^a   Andersson, A ^a   Jansson, Leif ^a,b  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Blood flow; Carbon monoxide; Heme oxygenase; Pancreatic islets

Indexed keywords

CARBON MONOXIDE; ENDOTHELIUM DERIVED RELAXING FACTOR; HEME OXYGENASE; HEME OXYGENASE INHIBITOR; MICROSPHERE; PROTOPORPHYRIN TIN; THIOBUTABARBITAL;

ADRENAL BLOOD FLOW; ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; COLON; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG MECHANISM; DUODENUM; ENZYME INHIBITION; GAS; INTESTINE BLOOD FLOW; KIDNEY BLOOD FLOW; MALE; MEAN ARTERIAL PRESSURE; MEASUREMENT; NONHUMAN; PANCREAS; PANCREAS BLOOD FLOW; PANCREAS ISLET; PERFUSION; PRIORITY JOURNAL; RAT; RAT STRAIN;

ANIMALS; BLOOD PRESSURE; CARBON MONOXIDE; ENZYME INHIBITORS; HEME OXYGENASE (DECYCLIZING); ISLETS OF LANGERHANS; MALE; METALLOPORPHYRINS; PROTOPORPHYRINS; RATS; RATS, SPRAGUE-DAWLEY; REGIONAL BLOOD FLOW; VASODILATOR AGENTS;

EID: 33751072656     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.1080/00365510600861063     Document Type: Article

References (17)

1. Brunicardi FC, Stagner J, Bonner-Weir S, Wayland H, Kleinman R, Livingston E, et al. Microcirculation of the islets of Langerhans. Long Beach Veterans Administration Regional Medical Education Center Symposium. Diabetes 1996;45:385-92.
2. Jansson L. The regulation of pancreatic islet blood flow. Diabetes Metab Rev 1994;10:407-16.
3. Moldovan S, Livingston E, Zhang RS, Kleinman R, Guth P, Brunicardi FC. Glucose-induced islet hyperemia is mediated by nitric oxide. Am J Surg 1996;171:16-20.
4. Svensson AM, Östenson CG, Sandler S, Efendic S, Jansson L. Inhibition of nitric oxide synthase by NG-nitro-L-arginine causes a preferential decrease in pancreatic islet blood flow in normal rats and spontaneously diabetic GK rats. Endocrinology 1994;135:849-53.
5. Carlsson PO, Andersson A, Jansson L. Cardiac natriuretic peptides and pancreatic islet blood flow in anesthetized rats. Horm Metab Res 2001;33:181-5.
6. Pannen BH. New insights into the regulation of hepatic blood flow after ischemia and reperfusion. Anesth Analg 2002;94:1448-57.
7. Suematsu M. Recent developments in hepatic circulatory physiology. Hepatogastroenterology 1999;46Suppl 2:1406-8.
8. Durante W. Carbon monoxide and bile pigments: surprising mediators of vascular function. Vasc Med 2002;7:195-202.
9. Kourembanas S. Hypoxia and carbon monoxide in the vasculature. Antioxid Redox Signal 2002;4:291-9.
10. Henningsson R, Alm P, Ekstrom P, Lundquist I. Heme oxygenase and carbon monoxide: regulatory roles in islet hormone release: a biochemical, immunohistochemical, and confocal microscopic study. Diabetes 1999;48:66-76.
11. Lundquist I, Alm P, Salehi A, Henningsson R, Grapengiesser E, Hellman B. Carbon monoxide stimulates insulin release and propagates Ca2+ signals between pancreatic beta cells. Am J Physiol Endocrinol Metab 2003;285:E1055-63.
12. Jansson L, Hellerström C. Stimulation by glucose of the blood flow to the pancreatic islets of the rat. Diabetologia 1983;25:45-50.
13. Jansson L, Hellerström C. A rapid method of visualizing the pancreatic islets for studies of islet capillary blood flow using non-radioactive microspheres. Acta Physiol Scand 1981;113:371-4.
14. Zhang F, Kaide JI, Rodriguez-Mulero F, Abraham NG, Nasjletti A. Vasoregulatory function of the heme-heme oxygenase-carbon monoxide system. Am J Hypertens 2001;14:62S-7S.
15. Kim HP, Ryter SW, Choi AM. CO as a cellular signaling molecule. Annu Rev Pharmacol Toxicol 2005.
16. Clemens MG, Zhang JX. Regulation of sinusoidal perfusion: in vivo methodology and control by endothelins. Semin Liver Dis 1999;19:383-96.
17. Hindlycke M, Jansson L. Glucose tolerance and pancreatic islet blood flow in rats after intraperitoneal administration of different anesthetic drugs. Uppsala J Med Sci 1992;97:27-35.