Synthesis development of a naphthyridinone p38 kinase inhibitor

Current Opinion in Drug Discovery and Development

Volumn 9, Issue 6, 2006, Pages 792-805

  Chung, John Y L ^a   Cvetovich, Raymond J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Heck; Naphthyridinone; p38 kinase; Re aromatization; Suzuki

Indexed keywords

2,6 DICHLOROACRYLANILIDE; 4 N TERT BUTYLCHLOROPIPERIDINE; 4 N TERT BUTYLPIPERIDINE; ANILIDE; BENZENE DERIVATIVE; DIFLUOROPHENYL; FORMIC ACID; ISOBUTYLCHLOROFORMATE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NAPHTHYRIDINONE DERIVATIVE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

AMIDATION; AROMATIZATION; CATALYST; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; GRIGNARD REACTION; HECK REACTION; NUCLEAR MAGNETIC RESONANCE; OXIDATION; REVIEW; SUZUKI REACTION; TRANSAMINATION;

ENZYME INHIBITORS; HUMANS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; NAPHTHYRIDINES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHARMACOLOGY, CLINICAL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33751044102     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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