Synthesis of a naphthyridone p38 MAP kinase inhibitor

Journal of Organic Chemistry

Volumn 71, Issue 22, 2006, Pages 8602-8609

  Chung, John Y L ^a   Cvetovich, Raymond J ^a   McLaughlin, Mark ^a   Amato, Joseph ^a   Tsay, Fuh Rong ^a   Jensen, Mark ^a   Weissman, Steve ^a   Zewge, Daniel ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHELATION; DISEASE CONTROL; DRUG PRODUCTS; ENZYME INHIBITION; MAGNESIUM COMPOUNDS; OXIDATION; PATIENT TREATMENT; SYNTHESIS (CHEMICAL); TEST FACILITIES;

CHEMOSELECTIVE GRIGNARD ADDITIONS; DIHYDROPYRIDYL ADDUCTS; PSORIASIS; RHEUMATOID ARTHRITIS;

ENZYMES;

4 (N TERT BUTYLPIPERIDINYL)MAGNESIUM CHLORIDE; 7 (1 TERT BUTYLPIPERIDIN 4 YL) 1 (2,6 DICHLOROPHENYL) 5 (2,4 DIFLUOROPHENYL) 1,6 NAPHTHYRIDIN 2(1H) ONE; CHLOROFORMIC ACID ISOBUTYL ESTER; MAGNESIUM CHLORIDE; MAGNESIUM DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NAPHTHYRIDINE DERIVATIVE; NAPHTHYRIDONE N OXIDE; PIPERIDINE DERIVATIVE; PIPERIDONE DERIVATIVE; PYRIDINE; PYRIDINE DERIVATIVE; QUATERNARY AMMONIUM DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; DRUG INDICATION; DRUG SYNTHESIS; GRIGNARD REACTION; HEATING; OXIDATION; PSORIASIS; RHEUMATOID ARTHRITIS;

CYCLIC N-OXIDES; ENZYME INHIBITORS; MOLECULAR STRUCTURE; NAPHTHYRIDINES; P38 MITOGEN-ACTIVATED PROTEIN KINASES;

EID: 33750435218     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo061618f     Document Type: Article

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