Synthesis antimicrobial and antifungal activity of some new 3-substituted derivatives of 4-(2,4-dichlorophenyl)-5-adamantyl-1H-1,2,4-triazole

Farmaco

Volumn 57, Issue 12, 2002, Pages 973-977

  Papakonstantinou Garoufalias, S ^a   Pouli, N ^a   Marakos, P ^a   Chytyroglou Ladas, A ^b  

^a UNIVERSITY OF ATHENS   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Antifungal activity; Antimicrobial activity; Substituted 1,2,4 triazoles

Indexed keywords

3' [[4 (2,4 DICHLOROPHENYL) 5 (TRICYCLO[3.3.1.1 3,7 ]DECAN 1 YL) 4H 1,2,4 TRIAZOL 3 YL]MERCAPTOACETYLAMINO]SPIRO[9H FLUORENE 9,2' THIAZOLIDIN 4' ONE]; 3' [[4 (2,4 DICHLOROPHENYL) 5 (TRICYCLO[3.3.1.1 3,7 ]DECAN 1 YL) 4H 1,2,4 TRIAZOL 3 YL]MERCAPTOACETYLAMINO]SPIRO[INDANE 1,2' THIAZOLIDIN 4' ONE]; 4 [[4 (2,4 DICHLOROPHENYL) 5 (TRICYCLO[3.3.1.1 3,7 ]DECAN 1 YL) 4H 1,2,4 TRIAZOL 3 YL]MERCAPTOACETYLAMINO] 4 AZA 1 THIASPIRO[4,3]OCTAN 3 ONE; 4 [[4 (2,4 DICHLOROPHENYL) 5 (TRICYCLO[3.3.1.1 3,7 ]DECAN 1 YL) 4H 1,2,4 TRIAZOL 3 YL]MERCAPTOACETYLAMINO] 4 AZA 1 THIASPIRO[4,4]NONAN 3 ONE; 4 [[4 (2,4 DICHLOROPHENYL) 5 (TRICYCLO[3.3.1.1 3,7 ]DECAN 1 YL) 4H 1,2,4 TRIAZOL 3 YL]MERCAPTOACETYLAMINO] 4 AZA 1 THIASPIRO[4,5]DECAN 3 ONE; [4 (2,4 DICHLOROPHENYL) 5 (TRICYCLO[3.3.1.1 3,7 ]DECAN 1 YL) 4H 1,2,4 TRIAZOL 3 YL]MERCAPTOACETIC ACID CYCLOBUTYLIDINE HYDRAZIDE; [4 (2,4 DICHLOROPHENYL) 5 (TRICYCLO[3.3.1.1 3,7 ]DECAN 1 YL) 4H 1,2,4 TRIAZOL 3 YL]MERCAPTOACETIC ACID CYCLOHEXYLIDENE HYDRAZIDE; [4 (2,4 DICHLOROPHENYL) 5 (TRICYCLO[3.3.1.1 3,7 ]DECAN 1 YL) 4H 1,2,4 TRIAZOL 3 YL]MERCAPTOACETIC ACID CYCLOPENTYLIDENE HYDRAZIDE; [4 (2,4 DICHLOROPHENYL) 5 (TRICYCLO[3.3.1.1 3,7 ]DECAN 1 YL) 4H 1,2,4 TRIAZOL 3 YL]MERCAPTOACETIC ACID FLUORENYLIDENE HYDRAZIDE; [4 (2,4 DICHLOROPHENYL) 5 (TRICYCLO[3.3.1.1 3,7 ]DECAN 1 YL) 4H 1,2,4 TRIAZOL 3 YL]MERCAPTOACETIC ACID INDANYLIDENE HYDRAZIDE; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; HYDRAZINE DERIVATIVE; HYDRAZONE DERIVATIVE; N [[4 (2,4 DICHLOROPHENYL)ADAMANTYL 1H 1,2,4 TRIAZOL 3 YLMERCAPTOACETYL]HYDRAZINE]; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG; 4 (2,4 DICHLOROPHENYL) 5 ADAMANTYL 1H 1,2,4 TRIAZOLE; 4-(2,4-DICHLOROPHENYL)-5-ADAMANTYL-1H-1,2,4-TRIAZOLE; TRIAZOLE DERIVATIVE;

ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; INFRARED RADIATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; CHEMISTRY; DRUG EFFECT; MICROBIOLOGICAL EXAMINATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; ANTIFUNGAL AGENTS; CANDIDA ALBICANS; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; STAPHYLOCOCCUS AUREUS; TRIAZOLES;

EID: 0036904422     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(02)01227-2     Document Type: Article

References (9)

1. Walser A., Flynn T., Mason C. Pentacyclic triazolodiazepines as PAF-antagonists. J. Heterocycl. Chem. 28:1991;1121-1125.
2. Ewiss N.F., Bahajaj A.A., Elsherbini E.A. Synthesis of heterocycles, part VI - synthesis and antimicrobial activity of some 4-amino-5-aryl-1,2,4-triazole-3-thiones and their derivatives. J. Heterocycl. Chem. 23:1986;1451-1458.
3. Bhat A.R., Bhat G.V., Shenoy G.G. Synthesis and in vitro antimicrobial activity of new 1,2,4-triazoles. J. Pharm. Pharmacol. 53:2001;267-272.
4. Kitazaki T., Tamura N., Tasaka A., Matsushita Y., Hayashi R., Konogi K., Itoh K. Optically active antifungal azoles. VI. Synthesis and antifungal activity of N-((1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1- yl)propyl)-N′-(4-substituted phenyl)-3-(2H,4H)-1,2,4-triazolones and 5-(1H,4H)-tetrazolones. Chem. Pharm. Bull. 44:1996;314-327.
5. Todoulou O.G., Papadaki-Valiraki A.E., Filippatos E.C., Ikeda S., De Clercq E. Synthesis and anti-myxovirus activity of some novel N,N′-disubstituted thioureas. Eur. J. Med. Chem. 29:1994;127-131.
6. Papakonstantinou-Garoufalias S., Marakos P., Tsantili-Kakoulidou A., Chytyroglou-Ladas A. Synthesis, lipophilicity and antimicrobial properties of some O-(5-aryl-1,2,4-triazol-3-yl-ethyl)benzaldoximes and O-(5-aryl-1,3,4-oxadiazol-2-yl-ethyl)benzaldoximes. Pharmazie. 53:1998;300-302.
7. Papakonstantinou-Garoufalias S., Tani E., Todoulou O., Papadaki-Valiraki A., Philippatos E., De Clercq E. Synthesis and pharmacochemical investigation of some novel 1,2,4-4H-triazoles with potential antiviral activity. J. Pharm. Pharmacol. 50:1998;117-124.
8. P. Marakos, S. Papakonstantinou-Garoufalias, E. Tani, P.N. Kourounakis, G. Athanasiou, A. Chytyroglou-Lada, Synthesis, antifungal and antioxidant properties of some new 5-substituted-4-amino(or aryl)-3-mercapto-4(H)-1,2,4-triazoles, Arzneim. Forsch./Drug Res. (2002) in press.
9. Karali N., Ilhan E., Gürsoy A., Kiraz M. New cyclohexylidenehydrazide and 4-aza-1-thiaspiro[4.5]decan-3-one derivatives of 3-phenyl-4(3H)quinazolinones. Farmaco. 53:1998;346-349.