Evaluation of the methoxytriazine herbicide prometon using a short-term fathead minnow reproduction test and a suite of in vitro bioassays

Environmental Toxicology and Chemistry

Volumn 25, Issue 8, 2006, Pages 2143-2153

  Villeneuve, Daniel L ^a   Murphy, Margaret B ^b,c   Kahl, Michael D ^a   Jensen, Kathleen M ^a   Butterworth, Brian C ^a   Makynen, Elizabeth A ^a   Durhan, Elizabeth J ^a   Linnum, Ann ^a   Leino, Richard L ^d   Curtis, Lawrence R ^e   Giesy, John P ^b,c   Ankley, Gerald T ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c CITY UNIVERSITY OF HONG KONG   (Hong Kong)

^d UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^e OREGON STATE UNIVERSITY   (United States)

Author keywords

Endocrine disrupting chemicals; Methoxytriazines; Reproduction; Secondary sex characteristics; Steroids

Indexed keywords

BIOASSAY; BIODIVERSITY; CELLS; CONCENTRATION (PROCESS); HEALTH HAZARDS; HORMONES;

ENDOCRINE-DISRUPTING CHEMICALS; METHOXYTRIAZINES; REPRODUCTION; SECONDARY SEX CHARACTERISTICS; STEROIDS;

HERBICIDES;

ANDROGEN RECEPTOR; AROMATASE; AROMATASE INHIBITOR; ATRATON; ESTRADIOL; ESTROGEN RECEPTOR; GLUCOCORTICOID RECEPTOR; HERBICIDE; PROMETON; SECBUMETON; TERBUMETON; TESTOSTERONE; TRIAZINE; UNCLASSIFIED DRUG; VITELLOGENIN;

BIOASSAY; CYPRINID; ENDOCRINE DISRUPTOR; ENZYME ACTIVITY; FECUNDITY; HERBICIDE; INHIBITOR; PHYSIOLOGICAL RESPONSE; REPRODUCTION;

ANIMAL TISSUE; ARTICLE; BIOASSAY; BODY WEIGHT; CONTROLLED STUDY; CYTOTOXICITY; ENDOCRINE FUNCTION; ENZYME ACTIVITY; ESTRADIOL BLOOD LEVEL; FEMALE; HUMAN; HUMAN CELL; LIPOPROTEIN BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; REPRODUCTION;

ANIMALS; AROMATASE; BIOLOGICAL ASSAY; CYPRINIDAE; HERBICIDES; HUMANS; REPRODUCTION; TRIAZINES; TUMOR CELLS, CULTURED;

NORTH AMERICA; UNITED STATES;

PIMEPHALES PROMELAS;

EID: 33751025241     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1897/05-604R.1     Document Type: Article

References (53)

1. Capel PD, Spexet AH, Larson SJ. 1999. Occurrence and behavior of the herbicide prometon in the hydrologic system. Environ Sci Technol 33:674-680.
2. Moreland DE. 1980. Mechanisms of action of herbicides. Annu Rev Plant Physiol 31:597-638.
3. Barbash JE, Theilen GP, Kolpin DW, Gilliom RJ. 1999. Distribution of major herbicides in groundwater of the United States. Investigations Report 98-4245. U.S. Geological Survey, Sacramento, CA.
4. Bruce BW, McMahon PB. 1996. Shallow ground-water quality beneath a major urban center: Denver, Colorado, USA. J Hydrol 186:129-151.
5. Adamski JC, Pugh AL. 1996. Occurrence of pesticides in groundwater of the Ozark Plateaus province. Water Resour Bull 32:97-105.
6. Kolpin DW, Barbash JE, Gilliom RJ. 1998. Occurrence of pesticides in shallow groundwater of the United States: Initial results from the National Water-Quality Assessment Program. Environ Sci Technol 32:558-566.
7. Larson SJ, Gilliom RJ, Capel PD. 1999. Pesticides in streams of the United States-Initial results from the National Water-Quality assessment program. Investigations Report 98-4222. U.S. Geological Survey, Sacramento, CA.
8. Hoffman RS, Capel PD, Larson SJ. 2000. Comparison of pesticides in eight U.S. urban streams. Environ Toxicol Chem 19: 2249-2258.
9. U.S. Environmental Protection Agency. 2002. Edition of the drinking water standards and health advisories. EPA 822-R-02-038. Office of Water, Washington, DC.
10. Singh G, Van Genuchten MT, Spencer WF, Cliath MM, Yates SR. 1996. Measured and predicted transport of two s-triazine herbicides through soil columns. Water Air Soil Pollut 86:137-149.
11. Stevens JT, Breckenridge CB, Wetzel LT, Gillis JH, Luempert LG, Eldridge JC. 1994. Hypothesis for mammary tumorigenesis in Sprague-Dawley rats exposed to certain triazine herbicides. J Toxicol Environ Heath 43:139-153.
12. Wetzel LT, Luempert LG, Breckenridge CB, Tisdel MO, Stevens JT, Thakur AK, Extrom PJ, Eldridge JC. 1994. Chronic effects of atrazine on estrus and mammary tumor formation in female Sprague-Dawley and Fischer 344 rats. J Toxicol Environ Health 43:169-182.
13. Eldridge JC, Fleenor-Heyser DG, Extrom PC, Wetzel LT, Breckenridge CB, Gillis JH, Luempert LG, Stevens JT. 1994. Short term effects of chlorotriazines on estrus in female Sprague-Dawley and Fischer 344 rats. J Toxicol Environ Health 43:155-167.
14. Grain DA, Guillette LJ, Rooney AA, Pickford DB. 1997. Alterations in steroidogenesis in alligators (Alligator mississippiensis) exposed naturally and experimentally to environmental contaminants. Environ Health Perspect 105:528-533.
15. Cooper RL, Stoker TE, Tyrey L, Goldman JM, McElroy WK. 2000. Atrazine disrupts the hypothalamic control of pituitary-ovarian function. Toxicol Sci 53:297-307.
16. Stoker TE, Laws SC, Guidici DL, Cooper RL. 2000. The effect of atrazine on puberty in male Wistar rats: An evaluation in the protocol for the assessment of pubertal development and thyroid function. Toxicol Sci 58:50-59.
17. Moore A, Lower N. 2001. The impact of two pesticides on olfactory-mediated endocrine function in mature male Atlantic salmon (Salmo salar L.) parr. Camp Biochem Physiol Part B 129:269-276.
18. Tavera-Mendoza L, Ruby S, Brousseau P, Founder M, Cyr D, Marcogliese D. 2002. Response of the amphibian tadpole Xenopus laevis to atrazine during sexual differentiation of the ovary. Environ Toxicol Chem 21:1264-1267.
19. Hayes TB, Collins A, Lee M, Mendoza M, Noriega N, Stuart AA, Vonk A. 2002. Hermaphoditic, demasculinized frogs after exposure to the herbicide, atrazine, at low ecologically relevant doses. Proc Natl Acad Sci 99:5476-5480.
20. Carr JA, Gentles A, Smith EE, Goleman WL, Urquidi LJ, Thuett K, Kendall RJ, Giesy JP, Gross TS, Solomon KR, Van der Kraak G. 2003. Response of larval Xenopus laevis to atrazine: Assessment of growth, metamorphosis, and gonadal and laryngeal morphology. Environ Toxicol Chem 22:396-405.
21. Pons M, Gagne D, Nicolas JC, Mehtali M. 1990. A new cellular model of response to estrogens: A bioluminescent test to characterize (anti)estrogen molecules. Biotechniques 9:450-459.
22. El-Fouly MH, Richter C, Giesy JP, Denison MS. 1994. Production of a novel recombinant cell line for use as a bioassay system for detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. Environ Toxicol Chem 13:1581-1588.
23. Khim JS, Villeneuve DL, Kannan K, Lee KT, Snyder SA, Koh CH, Giesy JP. 1999. Alkylphenols, polycyclic aromatic hydrocarbons (PAHs) and organochlorines in sediment from lake Shihwa, Korea: Instrumental and bioanalytical characterization. Environ Toxicol Chem 18:2424-2432.
24. Villeneuve DL, Khim JS, Kannan K, Giesy JP. 2001. In vitro response of fish and mammalian cells to complex mixtures of polychlorinated naphthalenes, polychlorinated biphenyls, and polycyclic aromatic hydrocarbons. Aquat Toxicol 54:125-141.
25. Villeneuve DL, Blankenship AL, Giesy JP. 2000. Derivation and application of relative potency estimates based on in vitro bioassay results. Environ Toxicol Chem 19:2835-2843.
26. Wilson VS, Bobseine K, Lambright CR, Gray LE. 2002. A novel cell line, MDA-kb2, that stably expresses an androgen- and glucocorticoid-responsive reporter for the detection of hormone receptor agonists and antagonists. Toxicol Sci 66:69-81.
27. Villeneuve DL, Richter CA, Blankenship AL, Giesy JP. 1999. Rainbow trout cell bioassay-derived relative potencies for halogenated aromatic hydrocarbons: Comparison and sensitivity analysis. Environ Toxicol Chem 18:879-888.
28. Rainey WE, Bird IM, Mason JI. 1994. The NCI-H294 cell line: A pluripotent model for human andrenocortical studies. Mol Cell Endocrinol 100:45-50.
29. Sanderson JT, Seinen W, Giesy JP, van den Berg M. 2000. 2-Chloro-s-triazine herbicides induce aromatase (CYP19) activity in H295R human adrenocortical carcinoma cells: A novel mechanism for estrogenicity? Toxicol Sci 54:121-127.
30. Letcher RJ, van Holsteijn I, Drenth H-J, Norstrom RJ, Bergman Å, Safe S, Pieters R, van den Berg M. 1999. Cytotoxicity and aromatase (CYP19) activity modulation by organochlorines in human placental JEG-3 and JAR choriocarcinoma cells. Toxicol Appl Pharmacol 160:10-20.
31. Ankley GT, Kuehl DW, Kahl MD, Jensen KM, Linnum AL, Leino RA, Villeneuve DL. 2005. Reproductive and developmental toxicity and bioconcentration of perfluorooctanesulfonate in a partial-life cycle test with the fathead minnow (Pimephales promelas). Environ Toxicol Chem 24:2316-2324.
32. Ankley GT, Jensen KM, Kahl MD, Korte JJ, Makynen EA. 2001. Description and evaluation of a short-term reproduction test with the fathead minnow (Pimephales promelas). Environ Toxicol Chem 20:1276-1290.
33. Ankley GT, Jensen KM, Durban EJ, Makynen EA, Butterworth BC, Kahl MD, Villeneuve DL, Linnum AL, Gray LE, Cardon M, Wilson VS. 2005. Effects of two fungicides with multiple modes of action on reproductive endocrine function in the fathead minnow (Pimephales promelas). Toxicol Sci 86:300-308.
34. Leino RL, Jensen KM, Ankley GT. 2005. Gonadal histology and characteristic histopathology associated with endocrine disruption in the fathead minnow (Pimephales promelas). Environ Toxicol Pharmacol 19:85-98.
35. U.S. Environmental Protection Agency. 2002. A short-term test method for assessing the reproductive toxicity of endocrine disrupting chemicals using the fathead minnow (Pimephales promelas). EPA/600/R-01/067. Washington, DC.
36. Lephart ED, Simpson ER. 1991. Assay of aromatase activity. In Waterman WR, Johnson EF eds, Methods in Enzymology, Vol 206-Enzyme Assays. Academic, New York, NY, USA, pp 477-483.
37. Villeneuve DL, Knoebl I, Kahl MD, Jensen KM, Hammermeister DE, Greene KJ, Blake LS, Ankley GT. 2006. Relationship between brain and ovary aromatase activity and isoform-specific aromatase mRNA expression in the fathead minnow (Pimephales promelas). Aquat Toxicol. 76:353-368.
38. Villeneuve D, Miracle A, Degitz S, Korte J, Kahl M, Jensen K, Ankley G. 2005. Quantitative RT-PCR assays for fathead minnow gonadotropin (FSHβ and LHβ subunits) mRNA expression: cDNA cloning and assay development. Abstracts, SETAC North
39. America, 26th Annual Meeting, Baltimore, MD, USA, November 13-17, p 365.
40. Barbash JE, Theilen GP, Kolpin DW, Gilliom RJ. 2001. Major herbicides in ground water: Results from the National Water-Quality Assessment. J Environ Qual 30:831-845.
41. Cooper RL, Stoker TE, Goldman JM, Parrish MB, Tyrey L. 1996. Effect of atrazine on ovarian function in the rat. Reprod Toxicol 10:257-264.
42. Tennant MK, Hill DC, Eldridge JC, Wetzel LT, Breckenridge CB, Stevens JT. 1994. Chloro-s-triazine antagonism of estrogen action: Limited interaction with estrogen receptor binding. J Toxicol Environ Health 43:197-211.
43. Connor K, Howell J, Chen I, Liu H, Berhane K, Sciaretta C, Safe S, Zacharewski T. 1996. Failure of chloro-s-triazine-derived compounds to induce estrogen receptor-mediated responses in vivo and in vitro. Fundam Appl Toxicol 30:93-101.
44. Sanderson JT, Lechter RJ, Heneweer M, Giesy JP, van den Berg M. 2001. Effects of chloro-s-triazine herbicides and metabolites on aromatase activity in various human cell lines and on vitellogenin production in male carp hepatocytes. Environ Health Perspect 109:1027-1031.
45. Oh SM, Shim SH, Chung KH. 2003. Antiestrogenic action of atrazine and its major metabolites in vitro. J Health Sci 49:65-71.
46. Bringolf RB, Beiden JB, Summerfelt RC. 2004. Effects of atrazine on fathead minnow in a short-term reproduction assay. Environ Toxicol Chem 23:1019-1025.
47. Battelle. 2005. Draft Final Report on Multi-chemical evaluation of the short-term reproduction assay with the fathead minnow. EPA Contract 68-W-01-023. Washington, DC.
48. Hayes TB. 1998. Sex determination and sex differentiation: Genetic and developmental mechanisms. J Exp Zool 281:373-399.
49. Smith RJF. 1974. Effects of 17 α-methyltestosterone on the dorsal pad and tubercles of fathead minnows (Pimephales promelas). Can J Zool 52:1031-1038.
50. Ankley GT, Jensen KM, Makynen EA, Kahl MD, Korte JJ, Hornung MW, Henry TR, Denny JS, Leino RL, Wilson VS, Cardon MC, Hartig PC, Gray LE. 2003. Effects of the androgenic growth promoter 17-β-trenbolone on fecundity and reproductive endocrinology of the fathead minnow. Environ Toxicol Chem 22: 1350-1360.
51. Vingaard AM, Hnida C, Breinholt V, Larsen JC. 2000. Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro. Toxicol in Vitro 14:227-234.
52. Hasty J, McMillen D, Collins JJ. 2002. Engineered gene circuits. Nature 420:224-230.
53. Kohn MC, Melnick RL. 2002. Biochemical origins of the non-monotonic receptor-mediated dose-response. J Mol Endocrinol 29:113-123.