Effects of an Oral Contraceptive (Norgestimate/Ethinyl Estradiol) on Bone Mineral Density in Adolescent Females with Anorexia Nervosa: A Double-Blind, Placebo-Controlled Study

Journal of Adolescent Health

Volumn 39, Issue 6, 2006, Pages 819-827

  Strokosch, Gary R ^a   Friedman, Andrew J ^b   Wu, Shu Chen ^c   Kamin, Marc ^d  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^c SCIOS INC   (United States)

^d Ortho Biotech Clinical Affairs   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETHINYLESTRADIOL PLUS NORGESTIMATE; ORAL CONTRACEPTIVE AGENT; PLACEBO;

ABDOMINAL PAIN; ADOLESCENT; ANOREXIA NERVOSA; ARTICLE; BODY MASS; BONE DENSITY; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMOGRAPHY; DISEASE EXACERBATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG INDUCED HEADACHE; DUAL ENERGY X RAY ABSORPTIOMETRY; DYSMENORRHEA; EATING DISORDER; FEMALE; FLU LIKE SYNDROME; HIP; HOSPITALIZATION; HUMAN; INCIDENCE; LUMBOSACRAL SPINE; MENSTRUATION DISORDER; NAUSEA; OSTEOPOROSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SINUSITIS; STATISTICAL SIGNIFICANCE; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT; UPPER RESPIRATORY TRACT INFECTION; WEIGHT GAIN;

ADOLESCENT; ANOREXIA NERVOSA; BONE DENSITY; CONTRACEPTIVES, ORAL, COMBINED; DOUBLE-BLIND METHOD; EATING DISORDERS; ETHINYL ESTRADIOL-NORGESTREL COMBINATION; FEMALE; HUMANS;

EID: 33751006766     PISSN: 1054139X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jadohealth.2006.09.010     Document Type: Article

References (38)

1. Klibanski A., Biller B.M., Schoenfeld D.A., et al. The effects of estrogen administration on trabecular bone loss in young women with anorexia nervosa. J Clin Endocrinol Metab 80 (1995) 898-904
2. Lucas A.R., Beard C.M., O'Fallon, et al. 50-year trends in the incidence of anorexia nervosa in Rochester, MN: a population-based study. Am J Psychiatry 148 (1991) 917-922
3. Von Ranson K., Iacono W., and McGue M. Disordered eating and substance abuse in an epidemiological sample: associations within individuals. Int J Eat Disord 31 (2002) 389-403
4. Seeman E., Szmukler G.I., Formica C., et al. Osteoporosis in anorexia nervosa: the influence of peak bone density, bone loss, oral contraceptive use, and exercise. J Bone Miner Res 7 (1992) 1467-1474
5. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. (1994), APA Press, Washington, DC 539-545
6. Adolescent Medicine Committee, and Canadian Paediatric Society (CPS). Eating disorders in adolescents: principles of diagnosis and treatment. Paediatr Child Health 3 (1998) 189-192
7. Watson T.L., and Andersen A.E. A critical examination of the amenorrhea and weight criterion for diagnosing anorexia nervosa. Acta Psychiatr Scand 108 (2003) 175-182
8. Mitchell J.E., Cook-Myers T., and Wonderlich S.A. Diagnostic criteria for anorexia nervosa: looking ahead to DSM-V. Int J Eat Disord 37 (2005) S95-S97
9. Mehler P.S. Osteoporosis in anorexia nervosa: prevention and treatment. Int J Eat Disord 33 (2003) 113-126
10. Bachrach L.K., Katzman D.K., Litt I.F., et al. Recovery from osteopenia in adolescent girls with anorexia nervosa. J Clin Endocrinol Metab 72 (1991) 602-606
11. Ward A., Brown N., and Treasure J. Persistent osteopenia after recovery from anorexia nervosa. Int J Eat Disord 22 (1997) 71-75
12. Soyka L.A., Misra M., Frenchman A., et al. Abnormal bone mineral acrrual in adolescent girls with anorexia nervosa. J Clin Endocrinol Metab 87 (2002) 4177-4185
13. Hergenroeder A.C. Bone mineralization, hypothalmic amenorrhea, and sex steroid therapy in female adolescents and young adults. J Pediatr 126 (1995) 683-689
14. Teegarden D., Proulx W.R., Martin B.R.J., et al. Peak bone mass in young women. J Bone Miner Res 10 (1995) 711-715
15. Weaver C.M. Adolescence: the period of dramatic bone growth. Endocrine 17 (2002) 43-48
16. Munoz M.T., and Argente J. Anorexia nervosa in female adolescents: endocrine and bone mineral density disturbances. Eur J Endocrinol 147 (2002) 275-286
17. Soyka L.A., Grinspoon S., Levitsky L.L., et al. The effects of anorexia nervosa on bone metabolism in female adolescents. J Clin Endocrinol Metab 84 (1999) 4489-4496
18. Osteoporosis-consensus conference. JAMA 252 (1984) 799-802
19. Torgerson D.J., and Bell-Syer S.E.M. Hormone replacement therapy and prevention of nonvertebral fractures: a meta-analysis of randomized trials. JAMA 285 (2001) 2891-2897
20. Golden N.H., Lanzkowsky L., Schebendach J., et al. The effect of estrogen-progestin treatment on bone mineral density in anorexia nervosa. J Pediatr Adolesc Gynecol 15 (2002) 135-143
21. Munoz M.T., Morande G., Garcia-Centenera J.A., et al. The effects of estrogen administration on bone mineral density in adolescents with anorexia nervosa. Eur J Endocrinol 146 (2002) 45-50
22. Robinson E., Bachrach L.K., and Katzman D.K. Use of hormone replacement therapy to reduce the risk of osteopenia in adolescent girls with anorexia nervosa. J Adolesc Health 26 (2000) 343-348
23. Hebebrand J., Wehmeier P.M., and Remschmidt H. Weight criteria for diagnosis of anorexia nervosa. Am J Psychiatry 157 (2000) 1024
24. National Center for Health Statistics in Collaboration with the National Center for Chronic Disease Prevention and Health Promotion. Body mass index-for-age percentiles: girls, 2-20 years [cited 2005 Nov]. Available from: http://www.cdc.gov/growthcharts
25. Hui S.L., Gao S., Zhou X.-H., et al. Universal standardization of bone density measurements: a method with optimal properties for calibration among several instruments. J Bone Miner Res 12 (1997) 1463-1470
26. Lu Y., Fuerst T., Hui S., et al. Standardization of bone mineral density at femoral neck, trochanter and ward's triangle. Osteoporos Int 12 (2001) 438-444
27. Bachrach L.K., Hastie T., Wang M.-C., et al. Bone mineral acquisition in healthy Asian, Hispanic, Black, and Caucasian youth: a longitudinal study. J Clin Endocrinol Metab 84 (1999) 4702-4712. http://www-stat-class.standford.edu/pediatric-bones/ Also available from Reference Database [cited 2005 Dec] http://www-stat-class.standford.edu/pediatric-bones/.
28. Senn S. Some controversies in planning and analyzing multi-centre trials. Stat Med 17 (1998) 1753-1765
29. Gulekli B., Davies M.C., and Jacobs H.S. Effect of treatment on established osteoporosis in young women with amenorrhoea. Clin Endocrinol 41 (1994) 275-281
30. Golden N.H., Iglesias E.A., Jacobsen M.S., et al. Alendronate for the treatment of osteopenia in anorexia nervosa: a randomized, double-blind, placebo-controlled trial. J Clin Endocrinol Metab 90 (2005) 3179-3185
31. Ott S.M. Letter re: Alendronate in anorexia nervosa. J Clin Endocrinol Metab 90 (2005) 5508
32. Nowson C.A., Green R.M., Hopper J.L., et al. A co-twin study of the effect of calcium supplementation on bone density during adolescence. Osteoporos Int 7 (1997) 219-225
33. Genant H.K., Lucas J., Weiss S., et al. Low-dose esterified estrogen therapy: effects on bone, plasma estradiol concentrations, endometrium, and lipid levels. Arch Intern Med 157 (1997) 2609-2615
34. Villareal D.T., Binder E.F., Williams D.B., et al. Bone mineral density response to estrogen replacement in frail elderly women. A randomized controlled trial. JAMA 286 (2001) 815-820
35. Fosamax package insert. Merck & Co., Inc. [cited 2005 Dec]. Available from: http://www.fosamax.com/fosamax/shared/documents/english/pi.pdf
36. Actonel package insert. Procter & Gamble Pharmaceuticals, Inc. [cited 2005 Dec]. Available from: http://www.pgpharma.com/pi/US-Actonel.pdf
37. Bachrach L.K. Measuring bone mass in children: can we really do it?. Horm Res 65 suppl 2 (2006) 11-16
38. Carter D.R., Bouxsein M.L., and Marcus R. New approaches for interpreting projected bone densitometry data. J Bone Miner Res 7 (1992) 137-145