Bone mineral density response to estrogen replacement in frail elderly women; A randomized controlled trial

Journal of the American Medical Association

Volumn 286, Issue 7, 2001, Pages 815-820

  Villareal, Dennis T ^a   Binder, Ellen F ^a   Yarasheski, Kevin E ^a   Williams, Daniel B ^b   Schechtman, Kenneth B ^c   Kohrt, Wendy M ^d,e  

^a Department of Internal Medicine   (United States)

^b Department of Obstetrics and Gynecology ^*  (United States)

^c Division of Biostatistics   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; COLLAGEN TYPE 1; CONJUGATED ESTROGEN PLUS MEDROXYPROGESTERONE ACETATE; ESTROGEN; PEPTIDE HORMONE; PLACEBO;

AGED; ARTICLE; BONE DENSITY; BONE DEVELOPMENT; BONE MATURATION; BONE MINERAL; BONE TURNOVER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DOUBLE BLIND PROCEDURE; DUAL ENERGY X RAY ABSORPTIOMETRY; ELDERLY CARE; ESTROGEN THERAPY; FEMALE; FRACTURE; HIP; HUMAN; HUMAN TISSUE; LUMBAR SPINE; MAJOR CLINICAL STUDY; OSTEOPOROSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS; TREATMENT OUTCOME; UNITED STATES;

EID: 0035880311     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.286.7.815     Document Type: Article

References (40)

1. Hip and calcaneal bone loss increase with advancing age: Longitudinal results from the study of osteoporotic fractures
2. Estrogen treatment of patients with established postmenopausal osteoporosis
3. Estrogen action on the bone mass of postmenopausal women is dependent on body mass and initial bone density
4. Do estrogens improve bone mineral density in osteoporotic women over age 65?
5. Estrogen therapy arrests bone loss in elderly women
6. 17 Beta-estradiol and continuous norethisterone: A unique treatment for established osteoporosis in elderly women
7. Treatment of postmenopausal osteoporosis with transdermal estrogen
8. The effect of low-dose continuous estrogen and progesterone therapy with calcium and vitamin D on bone in elderly women: A randomized, controlled trial
9. Estrogen replacement therapy and fractures in older women
10. The effect of postmenopausal estrogen therapy on bone density in elderly women
11. Timing of postmenopausal estrogen for optimal bone mineral density: The Rancho Bernardo Study
12. Do older women use estrogen replacement? Data from the Duke Established Populations for Epidemiologic Studies of the Elderly (EPESE)
13. Exercise
14. Physical and performance measures for the identification of mild to moderate frailty
15. Peak aerobic power is an important component of physical performance in older women
16. Effects of hormone replacement therapy on serum lipids in elderly women: A randomized, placebo-controlled trial
17. Effects of DHEA replacement on bone mineral density and body composition in elderly women and men
18. Differential effects of estrogen treatment on bone mineral density of the spine, hip, wrist and total body in late postmenopausal women
19. HRT preserves increases in bone mineral density and reductions in body fat after a supervised exercise program
20. Effects of hormone therapy on bone mineral density: Results from the Postmenopausal Estrogen/Progestin Interventions (PEPI) trial
21. Long-term prevention of postmenopausal osteoporosis by oestrogen: Evidence for an increased bone mass after delayed onset of oestrogen treatment
22. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older
23. Long-term effects of calcium supplementation on serum parathyroid hormone level, bone turnover, and bone loss in elderly women
24. Bone density at various sites for prediction of hip fractures
25. The role of estrogen in the prevention of osteoporosis
26. Osteoporosis: Trials and tribulations
27. Effects of age and menopause on vertebral bone density
28. Accelerated vertebral bone loss in relation to the menopause: A cross-sectional study on lumbar bone density in 286 women of 46 to 55 years of age
29. Rates of bone loss in normal women: Evidence of accelerated trabecular bone loss after the menopause
30. "Senile" osteoporosis reconsidered
31. Markers of bone resorption predict hip fracture in elderly women: The EPIDOS Prospective Study
32. A unitary model for involutional osteoporosis: Estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men
33. Estrogen preserves a normal intestinal responsiveness to 1, 25-dihydroxyvitamin D3 in oophorectomized women
34. Mechanism of renal calcium conservation with estrogen replacement therapy in women in early postmenopause: A clinical research center study
35. Effects of estrogen on response to edetic acid infusion in postmenopausal osteoporotic women
36. The pathophysiology and treatment of postmenopausal osteoporosis: An evidence-based approach to estrogen replacement therapy
37. Serum IL-6 level and the development of disability in older persons
38. Prevention of hip fractures: Risk factor modification
39. Risk factors for hip fracture not related to bone mass and their therapeutic implications