Statistics of cellular signal transduction as a race to the nucleus by multiple random walkers in compartment/phosphorylation space

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 45, 2006, Pages 16752-16757

  Lu, Ting ^a   Shen, Tongye ^a   Zong, Chenghang ^a   Hasty, Jeff ^a,b   Wolynes, Peter G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

First passage time; NFAT; Stochastic biology

Indexed keywords

CELL PROTEIN;

ARTICLE; CELL COMPARTMENTALIZATION; CELL SURVIVAL; PRIORITY JOURNAL; PROBABILITY; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SIMULATION; STATISTICAL ANALYSIS; STATISTICAL MODEL; STATISTICS;

ACTIVE TRANSPORT, CELL NUCLEUS; BIOPHYSICS; CELL COMPARTMENTATION; KINETICS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; MONTE CARLO METHOD; NFATC TRANSCRIPTION FACTORS; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 33750957815     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0607698103     Document Type: Article

References (29)

1. Huang C, Ferrell J (1996) Proc Natl Acad Sci USA 93:10078-10083.
2. Changeux J, Edelstein S (2005) Science 308:1424-1428.
3. Ferrel J (1996) Trends Biosci 21:460-466.
4. Ferrel J, Machleder E (1998) Science 280:895-898.
5. Roux PP, Blenis J (2004) Microbiol Mol Biol Rev 68:320-344.
6. Schaeffer HJ, Weber MJ (1999) Mol Cell Biol 19:2435-2444.
7. Doan T, Mendez A, Detwiler P, Chen J, Rieke F (2006) Science 313:530-533.
8. Bhalla US, Lyengar R (1999) Science 283:381-387.
9. Crabtree GR, Olson EN (2002) Cell 109:567-579.
10. Hogan GD, Chen L, Nardone J, Rao A (2003) Genes Dev 17:2205-2232.
11. Horsley V, Pavlath GK (2002) J Chem Biol 156:771-774.
12. Shen T, Zong C, Hamelberg D, McCammon JA, Wolynes PG (2005) FASEB J 19:1389-1395.
13. Salazar C, Höfer T (2003) J Mol Biol 327:31-45.
14. Gunawardena J (2005) Proc Natl Acad Sci USA 102:14617-14622.
15. Aubol BE, Chakrabarti S, Ngo J, Shaffer J, Holen B, Fu X, Ghosh G, Adams JA (2003) Proc Natl Acad Sci USA 100:12601-12606.
16. Samoilov M, Plyasunov S, Arkin AP (2004) Proc Natl Acad Sci USA 102:2310-2315.
17. Monod J, Wyman J, Changeux JP (1965) J Mol Biol 12:88-118.
18. McQuarrie D (1967) Stochastic Approach to Chemical Kinetics (Methuen, London), 1st Ed.
19. Van Kampen NG (2003) Stochastic Processes in Physics and Chemistry (Elsevier, Oxford), Revised Ed.
20. Lindenberg K, Seshadri V, Shuler K, Weiss G (1980) J Stat Phys 23:11-25.
21. Bedeaux D, Lindenberg K, Shuler K (1971) J Math Phys 12:2116-2123.
22. Yuste SB, Lindenberg K (1996) J Stat Phys 85:501-512.
23. Rao A, Luo C, Hogan PG (1997) Annu Rev Immunol 15:707-747.
24. Henkelman G, LaBute M, Tung C, Fenimore P, McMahon BH (2004) Proc Natl Acad Sci USA 102:15347-15351.
25. Gillespie D (1976) J Comput Phys 22:403-434.
26. Lu T, Volfson D, Tsimring L, Hasty J (2004) IEE Systems Biol 1:121-127.
27. Dolmetsch RE, Lewis RS, Goodnow CC, Healy JI (1997) Nature 386:855-858.
28. Li G, Qian H (2003) Cell Biochem Biophys 39:45-59.
29. Paulsson J, Ehrenberg M (2001) Q Rev Biophys 34:1-59.