Behavioural and psychological symptoms of Alzheimer type dementia are not correlated with plasma homocysteine concentration

Dementia and Geriatric Cognitive Disorders

Volumn 22, Issue 5-6, 2006, Pages 432-438

  Tabet, N ^a   Rafi, H ^b   Weaving, G ^c   Lyons, B ^b   Iversen, S A ^c  

^a UNIVERSITY OF BRIGHTON   (United Kingdom)

^b East Sussex and County Healthcare NHS Trust   (United Kingdom)

^c UK   (United Kingdom)

Author keywords

Alzheimer; Behavioural and psychological symptoms of dementia; Dementia; Folate; Homocysteine; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTINE;

AGED; ALZHEIMER DISEASE; ANALYTICAL PARAMETERS; ARTICLE; BEHAVIOR DISORDER; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEMENTIA; FEMALE; FOLIC ACID BLOOD LEVEL; HUMAN; LABORATORY; MALE; MENTAL DISEASE; NEUROPSYCHIATRY; PRIORITY JOURNAL; RISK FACTOR; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; SYMPTOMATOLOGY; VITAMIN BLOOD LEVEL;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; MALE; MENTAL DISORDERS; NEUROPSYCHOLOGICAL TESTS; PSYCHOLOGICAL TESTS; SEVERITY OF ILLNESS INDEX; VITAMIN B 12;

EID: 33750928796     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000095802     Document Type: Article

References (36)

1. Quadri P, Fragiacomo C, Pezzati R, Zanda E, Forloni G, Tettamanti M, Lucca U: Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia. Am J Clin Nutr 2004;80:114-122.
2. Stuerenburg HJ, Mueller-Thomsen T, Methner A: Vitamin B12 plasma concentrations in Alzheimer disease. Neuro Endocrinol Lett 2004;25:176-177.
3. Bottiglieri T: Folate, vitamin B12, and neuropsychiatric disorders. Nutr Rev 1996;54:382-390.
4. Engelborghs S, Vloeberghs E, Maertens K, Marien P, Somers N, Symons A, Clement F, Ketels V, Saerens J, Goeman J, Pickut BA, Vandevivere J, De Deyn PP: Correlations between cognitive, behavioural and psychological findings and levels of vitamin B12 and folate in patients with dementia. Int J Geriatr Psychiatry 2004;19:365-370.
5. Whyte EM, Mulsant BH, Butters MA, Qayyum M, Towers A, Sweet RA, Klunk W, Wisniewski S, DeKosky ST: Cognitive and behavioural correlates of low vitamin B12 levels in elderly patients with progressive dementia. Am J Geriatr Psychiatry 2002;10:321-327.
6. Nilsson K, Gustafson L, Hultberg B: Plasma homocysteine is a sensitive marker for tissue deficiency of both cobalamines and folates in a psychogeriatric population. Dement Geriatr Cogn Disord 1999;10:476-482.
7. Hultberg B, Isaksson A, Nilsson K, Gustafson L: Markers for the functional availability of cobalamin/ folate and their association with neuropsychiatric symptoms in the elderly. Int J Geriatr Psychiatry 2001;16:873-878.
8. Nilsson K, Gustafson L, Hultberg B: Improvement of cognitive functions after cobolamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine. Int J Geriatr Psychiatry 2001;16:609-614.
9. Nilsson K, Gustafson L, Hultberg B: Optimal use of markers for cobalamin and folate status in a psycho geriatric population. Int J Geriatr Psychiatry 2002;17:919-925.
10. Ho PI, Ortiz D, Rogers E, Shea TB: Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactovation and DNA damage. J Neurosci Res 2002;70:694-702.
11. Facila L, Nunez JE, Bertomeu Gonzalez V, Sanchis J, Bodi V, Chorro FJ, Llacer A, Chorro FJ: Early determination of homocysteine levels in acute coronary syndromes, is it an independent prognostic factor? Int J Cardiol 2005;100:275-279.
12. Virtanen JK, Voutilainen S, Happonen P, Alfthan G, Kaikkonen J, Mursu J, Rissanen TH, Kaplan GA, Korhonen MJ, Sivenius J, Salonen JT: Serum homocysteine, folate and risk of stroke: Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study. Eur J Cardiovasc Prev Rehabil 2005;12:369-375.
13. Adunsky A, Arinzon Z, Fidelman Z, Krasniansky I, Arad M, Gepstein R: Plasma homocysteine levels and cognitive status in long-term stay geriatric patients: a cross-Sectional study. Arch Gerontol Geriatr 2005;40:129-138.
14. Reif A, Pfuhlmann B, Lesch KP. Homocysteinemia as well as methylenetetrahydrofolate reductase polymorphism are associated with affective psychosis. Prog Neuropsychopharmacol Biol Psyciatry 2005;29:1162-1168.
15. Monji A, Yanagimoto K, Maekawa T, Sumida Y, Yamazaki K, Kojima K: Plasma folate and homocysteine levels may be related to interictal 'schizophrenia-like' psychosis in patients with epilepsy. J Clin Psychopharmacol 2005;25:3-5.
16. Chen CS, Tsai JC, Tsang HY, Kuo YT, Lin HF, Chiang IC, Devanand DP: Homocysteine levels, MTHFR C677T genotype, and MRI hyperintensities in late-onset major depressive disorder. Am J Geriatr Psychiatry 2005;13:869-875.
17. Atmaca M, Tezcan E, Kuloglu M, Kirtas O, Ustundag B: Serum folate and homocysteine levels in patients with obsessive-compulsive disorder. Psychiatry Clin Neurosci 2005;59: 616-620.
18. Regland B, Abrahamsson L, Blennow K, Grenfeldt B, Gottfries CG: CSF-methionine is elevated in psychotic patients. J Neural Transm 2004;111:631-640.
19. Ballard CG, Thomas A, Fossey J, Lee L, Jacoby R, Lana MM, Bannister C, McShane R, Swann A, Juszczak E, O'Brien JT: A 3-month, randomized, placebo-controlled, neuroleptic discontinuation study in 100 people with dementia: the neuropsychiatric inventory median cutoff is a predictor of clinical outcome. J Clin Psychiatry 2004;65:114-119.
20. Frisoni GB, Rozzini L, Gozzetti A, Binetti G, Zanetti O, Bianchetti A, Trabucchi M, Cummings JL: Behavioral syndromes in Alzheimer's disease: description and correlates. Dement Geriatr Cogn Disord 1999;10:130-138.
21. Street JS, Clark WS, Gannon KS, Cummings JL, Bymaster FP, Tamura RN, Mitan SJ, Kadam DL, Sanger TM, Feldman PD, Tollefson GD, Breier A: Olanzapine treatment of psychotic and behavioral symptoms in patients with Alzheimer disease in nursing care facilities: a double-blind, randomized, placebo-controlled trial. The HGEU Study Group. Arch Study Gen Psychiatry 2000;57:968-976.
22. Lyketsos CG, Breitner JC, Rabins PV: An evidence-based proposal for the classification of neuropsychiatric disturbance in Alzheimer's disease. Int J Geriatr Psychiatry 2001;16:1037-1042.
23. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, ed 4. Washington, DC, USA, 1994.
24. Folstein MF, Folstein S, McHugh PR: Minimental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189.
25. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J: The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994;44:2308-2314.
26. Schafer JH, Glass TA, Bolla KI, Mintz M, Jedlicka AE, Schwartz BS: Homocysteine and cognitive function in a population-based study of older adults. J Am Geriatr Soc 2005;53:381-388.
27. Budge MM, de Jager C, Hogervorst E, Smith AD; Oxford Project to Investigate Memory and Ageing (OPTIMA): Total plasma homocysteine, age, systolic blood pressure, and cognitive performance in older people. J Am Geriatr Soc 2002;50:2014-2018.
28. Prins ND, Den Heijer T, Hofman A, Koudstaal PJ, Jolles J, Clarke R, Breteler MM; Rotterdam Scan Study: Homocysteine and cognitive function in the elderly: the Rotterdam Scan Study. Neurology 2002;59:1375-1380.
29. Nurk E, Refsum H, Tell GS, Engedal K, Vollset SE, Ueland PM, Nygaard HA, Smith AD: Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study. Ann Neurol 2005;58:847-857.
30. Elias MF, Sullivan LM, D'Agostino RB, Elias PK, Jacques PF, Selhub J, Seshadri S, Au R, Beiser A, Wolf PA: Homocysteine and cognitive performance in the Framingham offspring study: age is important. Am J Epidemiol 2005;162:644-653.
31. Irizarry MC, Gurol ME, Raju S, Diaz-Arrastia R, Locascio JJ, Tennis M, Hyman BT, Greenberg SM, Bottiglieri T: Association of liomocysteine with plasma amyloid beta protein in aging and neurodegenerative disease. Neurology 2005;65:1402-1408.
32. Tabet N, Mantle D, Walker Z, Orrel M: Endogenous antioxidant activities in relation to concurrent vitamin A,C and E intake in dementia. Int Psychogeriatr 2002;14:7-15.
33. Guerin O, Soto ME, Brocker P, Robert PH, Benoit M, Vellas B, the REAL French Study Group: Nutritional status assessment during Alzheimer's disease: results after one year. J Nutr Health Aging 2005;9:81-84.
34. Renvall MJ, Spindler AA, Ramsdell JW, Paskvan M: Nutritional status of free-living Alzheimer's patients. Am J Med Sci 1989;298:20-27.
35. Piccininni M, Di Carlo A, Baldereschi M, Zaccara G, Inzitari D: Behavioural and psychological symptoms in Alzheimer's disease: frequency and relationship with duration and severity of the disease. Dement Geriatr Cogn Disord 2005;19:276-281.
36. Rymer S, Salloway S, Norton L, Malloy P, Correia S, Monast D: Impaired awareness, behavior disturbance, and caregiver burden in Alzheimer disease. Alzheimer Dis Assoc Disord 2002;16:248-253.