Fenretinide-induced neuronal differentiation of ARPE-19 human retinal pigment epithelial cells is associated with the differential expression of Hsp70, 14-3-3, Pax-6, Tubulin β-III, NSE, and Bag-1 proteins

Molecular Vision

Volumn 12, Issue , 2006, Pages 1355-1363

  Chen, Shanyi ^a   Fariss, Robert N ^b   Kutty, R Krishnan ^a   Nelson, Ralph ^c   Wiggert, Barbara ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL EYE INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BAG 1 PROTEIN; BETA TUBULIN; FENRETINIDE; HEAT SHOCK PROTEIN 70; MONOCLONAL ANTIBODY; NEURON SPECIFIC ENOLASE; PROTEIN 14 3 3; TRANSCRIPTION FACTOR PAX6;

ARTICLE; CELL CULTURE; CELL CYCLE; CELL DIFFERENTIATION; CELL GROWTH; CELL NUCLEUS; CELL STRAIN; CELL STRUCTURE; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NONHUMAN; PIGMENT CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION; STRESS; WESTERN BLOTTING;

14-3-3 PROTEINS; ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINE; DNA-BINDING PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EYE PROTEINS; FENRETINIDE; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; NEURONS; PAIRED BOX TRANSCRIPTION FACTORS; PIGMENT EPITHELIUM OF EYE; PROTEINS; RATS; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TUBULIN;

EID: 33750896505     PISSN: 10900535     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Yeo M, Lee SK, Lee B, Ruiz EC, Pfaff SL, Gill GN. Small CTD phosphatases function in silencing neuronal gene expression. Science 2005; 307:596-600.
2. Hanashima C, Li SC, Shen L, Lai E, Fishell G. Foxg1 suppresses early cortical cell fate. Science 2004; 303:56-9.
3. Diez del Corral R, Storey KG. Opposing FGF and retinoid pathways: a signalling switch that controls differentiation and patterning onset in the extending vertebrate body axis. Bioessays 2004; 26:857-69.
4. Bibel M, Richter J, Schrenk K, Tucker KL, Staiger V, Korte M, Goetz M, Barde YA. Differentiation of mouse embryonic stem cells into a defined neuronal lineage. Nat Neurosci 2004; 7:1003-9.
5. Anchan RM, Reh TA, Angello J, Balliet A, Walker M. EGF and TGF-alpha stimulate retinal neuroepithelial cell proliferation in vitro. Neuron 1991; 6:923-36.
6. Bok D. The retinal pigment epithelium: a versatile partner in vision. J Cell Sci Suppl 1993; 17:189-95.
7. Yan RT, Ma WX, Wang SZ. neurogenin2 elicits the genesis of retinal neurons from cultures of nonneural cells. Proc Natl Acad Sci U S A 2001; 98:15014-9.
8. Dunn KC, Aotaki-Keen AE, Putkey FR, Hjelmeland LM. ARPE-19, a human retinal pigment epithelial cell line with differentiated properties. Exp Eye Res 1996; 62:155-69.
9. Dunn KC, Marmorstein AD, Bonilha VL, Rodriguez-Boulan E, Giordano F, Hjelmeland LM. Use of the ARPE-19 cell line as a model of RPE polarity: basolateral secretion of FGF5. Invest Ophthalmol Vis Sci 1998; 39:2744-9.
10. Davis AA, Bernstein PS, Bok D, Turner J, Nachtigal M, Hunt RC. A human retinal pigment epithelial cell line that retains epithelial characteristics after prolonged culture. Invest Ophthalmol Vis Sci 1995; 36:955-64.
11. Janssen JJ, Kuhlmann ED, van Vugt AH, Winkens HJ, Janssen BP, Deutman AF, Driessen CA. Retinoic acid delays transcription of human retinal pigment neuroepithelium marker genes in ARPE-19 cells. Neuroreport 2000; 11:1571-9.
12. Mannerstrom M, Zorn-Kruppa M, Diehl H, Engelke M, Toimela T, Maenpaa H, Huhtala A, Uusitalo H, Salminen L, Pappas P, Marselos M, Mantyla M, Mantyla E, Tahti H. Evaluation of the cytotoxicity of selected systemic and intravitreally dosed drugs in the cultures of human retinal pigment epithelial cell line and of pig primary retinal pigment epithelial cells. Toxicol In Vitro 2002; 16:193-200.
13. Chen S, Samuel W, Fariss RN, Duncan T, Kutty RK, Wiggert B. Differentiation of human retinal pigment epithelial cells into neuronal phenotype by N-(4-hydroxyphenyl)retinamide. J Neurochem 2003; 84:972-81.
14. Costa A, De Palo G, Decensi A, Formelli F, Chiesa F, Nava M, Camerini T, Marubini E, Veronesi U. Retinoids in cancer chemoprevention. Clinical trials with the synthetic analogue fenretinide. Ann N Y Acad Sci 1995; 768:148-62.
15. Radu RA, Han Y, Bui TV, Nusinowitz S, Bok D, Lichter J, Widder K, Travis GH, Mata NL. Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases. Invest Ophthalmol Vis Sci 2005; 46:4393-401.
16. Formelli F, Barua AB, Olson JA. Bioactivities of N-(4-hydroxyphenyl) retinamide and retinoyl beta-glucuronide. FASEB J 1996; 10:1014-24.
17. Le Doze F, Debruyne D, Albessard F, Barre L, Defer GL. Pharmacokinetics of all-trans retinoic acid, 13-cis retinoic acid, and fenretinide in plasma and brain of Rat. Drug Metab Dispos 2000; 28:205-8.
18. Berg D, Holzmann C, Riess O. 14-3-3 proteins in the nervous system. Nat Rev Neurosci 2003; 4:752-62.
19. Moore B, Perez V. Specific acidic proteins of the nervous system. In: Carlson FD, editor. Physiological and biochemical aspects of nervous integration. Englewood Cliffs (NJ): Prentice-Hall; 1967. p. 343-59.
20. Dougherty MK, Morrison DK. Unlocking the code of 14-3-3. J Cell Sci 2004; 117:1875-84.
21. Bridges D, Moorhead GB. 14-3-3 proteins: a number of functions for a numbered protein. Sci STKE 2004; 2004:re10.
22. Mhawech P. 14-3-3 proteins-an update. Cell Res 2005; 15:228-36.
23. Takihara Y, Matsuda Y, Irie K, Matsumoto K, Hara J. 14-3-3 protein family members have a regulatory role in retinoic acidmediated induction of cytokeratins in F9 cells. Exp Cell Res 2000; 260:96-104.
24. Miao B, Davis J, Craig EA. The Hsp70 family-an overview. In: Gething M, editor. Guidebook to Molecular Chaperones and protein-folding catalysts. Oxford: Oxford University Press; 1997. p. 3-13.
25. Wegele H, Muller L, Buchner J. Hsp70 and Hsp90-a relay team for protein folding. Rev Physiol Biochem Pharmacol 2004; 151:1-44.
26. Pilon M, Schekman R. Protein translocation: how Hsp70 pulls it off. Cell 1999; 97:679-82.
27. Walsh D, Grantham J, Zhu XO, Wei Lin J, van Oosterum M, Taylor R, Edwards M. The role of heat shock proteins in mammalian differentiation and development. Environ Med 1999; 43:79-87.
28. Kwak HJ, Jun CD, Pae HO, Yoo JC, Park YC, Choi BM, Na YG, Park RK, Chung HT, Chung HY, Park WY, Seo JS. The role of inducible 70-kDa heat shock protein in cell cycle control, differentiation, and apoptotic cell death of the human myeloid leukemic HL-60 cells. Cell Immunol 1998; 187:1-12.
29. Morishima N. Control of cell fate by Hsp70: more than an evanescent meeting. J Biochem (Tokyo) 2005; 137:449-53.
30. Tombran-Tink J, Chader GG, Johnson LV. PEDF: a pigment epithelium-derived factor with potent neuronal differentiative activity. Exp Eye Res 1991; 53:411-4.
31. Levi A, Shechter Y, Neufeld EJ, Schlessinger J. Mobility, clustering, and transport of nerve growth factor in embryonal sensory cells and in a sympathetic neuronal cell line. Proc Natl Acad Sci U S A 1980; 77:3469-73.
32. Belecky-Adams T, Tomarev S, Li HS, Ploder L, McInnes RR, Sundin O, Adler R. Pax-6, Prox 1, and Chx10 homeobox gene expression correlates with phenotypic fate of retinal precursor cells. Invest Ophthalmol Vis Sci 1997; 38:1293-303.
33. Davis JA, Reed RR. Role of Olf-1 and Pax-6 transcription factors in neurodevelopment. J Neurosci 1996; 16:5082-94.
34. Perentes E, Herbort CP, Rubinstein LJ, Herman MM, Uffer S, Donoso LA, Collins VP. Immunohistochemical characterization of human retinoblastomas in situ with multiple markers. Am J Ophthalmol 1987; 103:647-58.
35. von Deimling A, Kleihues P, Saremaslani P, Yasargil MG, Spoerri O, Sudhof TC, Wiestler OD. Histogenesis and differentiation potential of central neurocytomas. Lab Invest 1991; 64:585-91.
36. Marley EF, Liapis H, Humphrey PA, Nadler RB, Siegel CL, Zhu X, Brandt JM, Dehner LP. Primitive neuroectodermal tumor of the kidney - another enigma: a pathologic, immunohistochemical, and molecular diagnostic study. Am J Surg Pathol 1997; 21:354-9.
37. Marangos PJ, Schmechel D, Zis AP, Goodwin FK. The existence and neurobiological significance of neuronal and glial forms of the glycolytic enzyme enolase. Biol Psychiatry 1979; 14:563-79.
38. Amemiya K, Haruta M, Takahashi M, Kosaka M, Eguchi G. Adult human retinal pigment epithelial cells capable of differentiating into neurons. Biochem Biophys Res Commun 2004; 316:1-5.
39. Bain G, Kitchens D, Yao M, Huettner JE, Gottlieb DI. Embryonic stem cells express neuronal properties in vitro. Dev Biol 1995; 168:342-57.
40. Laeng P, Pitts RL, Lemire AL, Drabik CE, Weiner A, Tang H, Thyagarajan R, Mallon BS, Altar CA. The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells. J Neurochem 2004; 91:238-51.
41. Boston PF, Jackson P, Kynoch PA, Thompson RJ. Purification, properties, and immunohistochemical localisation of human brain 14-3-3 protein. J Neurochem 1982; 38:1466-74.
42. Skoulakis EM, Davis RL. 14-3-3 proteins in neuronal development and function. Mol Neurobiol 1998; 16:269-84.
43. Wang X, Grammatikakis N, Siganou A, Stevenson MA, Calderwood SK. Interactions between extracellular signal-regulated protein kinase 1, 14-3-3epsilon, and heat shock factor 1 during stress. J Biol Chem 2004; 279:49460-9.
44. Wang X, Grammatikakis N, Siganou A, Calderwood SK. Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1. Mol Cell Biol 2003; 23:6013-26.
45. Hartl FU, Hayer-Hartl M. Molecular chaperones in the cytosol: from nascent chain to folded protein. Science 2002; 295:1852-8.
46. Townsend PA, Cutress RI, Sharp A, Brimmell M, Packham G. BAG-1: a multifunctional regulator of cell growth and survival. Biochim Biophys Acta 2003; 1603:83-98.
47. Liman J, Ganesan S, Dohm CP, Krajewski S, Reed JC, Bahr M, Wouters FS, Kermer P. Interaction of BAG1 and Hsp70 mediates neuroprotectivity and increases chaperone activity. Mol Cell Biol 2005; 25:3715-25.
48. Wang HG, Takayama S, Rapp UR, Reed JC. Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. Proc Natl Acad Sci U S A 1996; 93:7063-8.
49. Gotz R, Wiese S, Takayama S, Camarero GC, Rossoll W, Schweizer U, Troppmair J, Jablonka S, Holtmann B, Reed JC, Rapp UR, Sendtner M. Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells. Nat Neurosci 2005; 8:1169-78.
50. Kermer P, Krajewska M, Zapata JM, Takayama S, Mai J, Krajewski S, Reed JC. Bag1 is a regulator and marker of neuronal differentiation. Cell Death Differ 2002; 9:405-13.