Strategy for the enantioselective synthesis of trans-2,4-disubstituted piperidines: Application to the CCR3 antagonist IS811

Journal of Organic Chemistry

Volumn 71, Issue 23, 2006, Pages 8975-8977

  Kauffman, Goss S ^a,b   Watson, Paul S ^a,c   Nugent, William A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b PFIZER INC   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONE; AMINATION; HYDROGENATION; INVERSE KINEMATICS; REACTION KINETICS; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

CCR3 ANTAGONIST; DIASTEREOSELECTIVE HYDROGENATION; ETHYL PROPIOLATE; TRANS-2,4-DISUBSTITUTED PIPERIDINES;

NITROGEN COMPOUNDS;

CARBON; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR3; EPICHLOROHYDRIN; ETHYLPROPIOLATE; IS 811; LACTONE; PIPERIDINE DERIVATIVE; PROPIOLACTONE; UNCLASSIFIED DRUG;

AMINATION; ARTICLE; CHEMICAL STRUCTURE; DIASTEREOISOMER; ENANTIOMER; ENANTIOSELECTIVITY; HYDROGENATION; LITHIATION; SYNTHESIS; TRANS ISOMER;

CATALYSIS; HUMANS; HYDROGEN; MOLECULAR CONFORMATION; PIPERIDINES; RECEPTORS, CHEMOKINE; STEREOISOMERISM;

EID: 33750881162     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0616963     Document Type: Article

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