Identification of USF2 as a key regulator of Runx2 expression in mouse pluripotent mesenchymal D1 cells

Molecular and Cellular Biochemistry

Volumn 292, Issue 1-2, 2006, Pages 79-88

  Wang, Chihuei ^a   Lee, Grace ^a   Hsu, Wayne ^a   Yeh, Ching Hua ^a   Ho, Mei Ling ^a   Wang, Gwo Jaw ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

D1 cells; E box; Mesenchymal stem cells; Osteoblast; Osteogenesis; Promoter; Runx2; Transcription; USF1; USF2

Indexed keywords

TRANSCRIPTION FACTOR RUNX2; UPSTREAM STIMULATORY FACTOR 2;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL FUNCTION; CELL NUCLEUS; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; MESENCHYME CELL; MOUSE; NONHUMAN; OSTEOBLAST; PLURIPOTENT STEM CELL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; REPORTER GENE; SITE DIRECTED MUTAGENESIS;

ANIMALS; BASE PAIRING; BASE SEQUENCE; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DIMERIZATION; DNA; MESENCHYMAL STEM CELLS; MICE; MOLECULAR SEQUENCE DATA; PLURIPOTENT STEM CELLS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; REPRESSOR PROTEINS; SEQUENCE DELETION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; UPSTREAM STIMULATORY FACTORS;

EID: 33750725121     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-006-9220-9     Document Type: Article

References (38)

1. Yamaguchi A, Komori T, Suda T: Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1. Endocr Rev 21: 393-411, 2000
2. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao YH, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T: Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89: 755-764, 1997
3. Inada M, Yasui T, Nomura S, Miyake S, Deguchi K, Himeno M, Sato M, Yamagiwa H, Kimura T, Yasui N, Ochi T, Endo N, Kitamura Y, Kishimoto T, Komori T: Maturational disturbance of chondrocytes in Cbfa1-deficient mice. Dev Dyn 214: 279-290, 1999
4. Mundlos S, Otto F, Mundlos C, Mulliken JB, Aylsworth AS, Albright S, Lindhout D, Cole WG, Henn W, Knoll JH., Owen MJ, Mertelsmann R, Zabel BU, Olsen BR: Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell 89: 773-779, 1997
5. Lee B, Thirunavukkarasu K, Zhou L, Pastore L, Baldini A, Hecht J, Geoffroy V, Ducy P, Karsenty G: Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia. Nat Genet 16: 307-310, 1997
6. Mundlos S: Cleidocranial dysplasia: Clinical and molecular genetics. J Med Genet 36: 177-182, 1999
7. Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC, Rosewell IR, Stamp GW, Beddington RS, Mundlos S, Olsen BR, Selby PB, Owen MJ: Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89: 765-771, 1997
8. Nishimura R, Hata K, Harris SE, Ikeda F, Yoneda T: Core-binding factor alpha 1 (Cbfa1) induces osteoblastic differentiation of C2C12 cells without interactions with Smad1 and Smad5. Bone 31: 303-312, 2002
9. Ducy P: Cbfa1: A molecular switch in osteoblast biology. Dev Dyn 219: 461-471, 2000
10. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G: Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation. Cell 89: 747-754, 1997
11. Jimenez MJ, Balbin M, Lopez JM., Alvarez J, Komori T, Lopez-Otin C: Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. Mol Cell Biol 19: 4431-4442, 1999
12. Hess J, Porte D, Munz C, Angel P: AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element. J Biol Chem 276: 20029-20038, 2001
13. Xiao ZS, Thomas R, Hinson TK, Quarles LD: Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor. Gene 214: 187-197, 1998
14. Xiao ZS, Liu SG, Hinson TK, Quarles LD: Characterization of the upstream mouse Cbfa1/Runx2 promoter. J Cell Biochem 82: 647-659, 2001
15. Drissi H, Luc Q, Shakoori R, Chuva De Sousa Lopes S, Choi JY, Terry A, Hu M, Jones S, Neil JC, Lian JB, Stein JL, Van Wijnen AJ, Stein GS: Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene. J Cell Physiol 184: 341-350, 2000
16. Takeda S, Bonnamy JP, Owen MJ, Ducy P, Karsenty G: Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice. Genes Dev 15: 467-481, 2001
17. Zambotti A, Makhluf H, Shen J, Ducy P: Characterization of an osteoblast-specific enhancer element in the CBFA1 gene. J Biol Chem 277: 41497-41506, 2002
18. Drissi H, Pouliot A, Stein JL, van Wijnen AJ, Stein GS, Lian JB: Identification of novel protein/DNA interactions within the promoter of the bone-related transcription factor Runx2/Cbfa1. J Cell Biochem 86: 403-412, 2002
19. Drissi H, Pouliot A, Koolloos C, Stein JL, Lian JB, Stein GS, van Wijnen AJ: 1, 25-(OH)2-vitamin D3 suppresses the bone-related Runx2/Cbfa1 gene promoter. Exp Cell Res 274: 323-333, 2002
20. Diduch DR, Coe MR, Joyner C, Owen ME, Balian G: Two cell lines from bone marrow that differ in terms of collagen synthesis, osteogenic characteristics, and matrix mineralization. J Bone Joint Surg Am 75: 92-105, 1993
21. Dahir GA, Cui Q, Anderson P, Simon C, Joyner C, Triffitt JT, Balian G: Pluripotential mesenchymal cells repopulate bone marrow and retain osteogenic properties. Clin Orthop Relat Res S134-145, 2000
22. Shen FH, Visger JM, Balian G, Hurwitz SR, Diduch DR: Systemically administered mesenchymal stromal cells transduced with insulin-like growth factor-I localize to a fracture site and potentiate healing. J Orthop Trauma 16: 651-659, 2002
23. Wang C, Yeung F, Liu PC, Attar RM, Geng J, Chung LW, Gottardis M, Kao C: Identification of a novel transcription factor, GAGATA-binding protein, involved in androgen-mediated expression of prostate-specific antigen. J Biol Chem 278: 32423-32430, 2003
24. Ishida S, Takada S, Koike K: Isolation and analysis of cellular DNA fragments directly binding to c-Myc protein. Leukemia 11(Suppl 3): 399-401, 1997
25. Nair SK, Burley SK: X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors. Cell 112: 193-205, 2003
26. Luo X, Sawadogo M: Functional domains of the transcription factor USF2: Atypical nuclear localization signals and context-dependent transcriptional activation domains. Mol Cell Biol 16: 1367-1375, 1996
27. Karsenty G, Ducy P, Starbuck M, Priemel M, Shen J, Geoffroy V, Amling M: Cbfa1 as a regulator of osteoblast differentiation and function. Bone 25: 107-108, 1999
28. Karsenty G: Minireview: Transcriptional control of osteoblast differentiation. Endocrinology 142: 2731-2733, 2001
29. Vallet VS, Henrion AA, Bucchini D, Casado M, Raymondjean M, Kahn A, Vaulont S: Glucose-dependent liver gene expression in upstream stimulatory factor 2 -/-mice. J Biol Chem 272: 21944-21949, 1997
30. Fisher DE, Parent LA, Sharp PA: Myc/Max and other helix-loop-helix/ leucine zipper proteins bend DNA toward the minor groove. Proc Natl Acad Sci USA 89: 11779-11783, 1992
31. Moriizumi S, Gourdon L, Lefrancois-Martinez AM, Kahn A, Raymondjean M: Effect of different basic helix-loop-helix leucine zipper factors on the glucose response unit of the L-type pyruvate kinase gene. Gene Expr 7: 103-113, 1998
32. Portois L, Tastenoy M, Viollet B, Svoboda M: Functional analysis of the glucose response element of the rat glucagon receptor gene in insulin-producing INS-1 cells. Biochim Biophys Acta 1574: 175-186, 2002
33. Smih F, Rouet P, Lucas S, Mairal A, Sengenes C, Lafontan M, Vaulont S, Casado M, Langin D: Transcriptional regulation of adipocyte hormone-sensitive lipase by glucose. Diabetes 51: 293-300, 2002
34. Bidder M, Shao JS, Charlton-Kachigian N, Loewy AP, Semenkovich CF, Towler DA: Osteopontin transcription in aortic vascular smooth muscle cells is controlled by glucose-regulated upstream stimulatory factor and activator protein-1 activities. J Biol Chem 277: 44485-44496, 2002
35. Cui Q, Wang GJ, Su CC, Balian G: The Otto Aufranc Award. Lovastatin prevents steroid induced adipogenesis and osteonecrosis. Clin Orthop Relat Res 344: 8-19, 1997
36. Cui Q, Wang GJ, Balian G: Pluripotential marrow cells produce adipocytes when transplanted into steroid-treated mice. Connect Tissue Res 41: 45-56, 2000
37. Lee MH, Kim YJ, Yoon WJ, Kim JI, Kim BG, Hwang YS, Wozney JM, Chi XZ, Bae SC, Choi KY, Cho JY, Choi JY, Ryoo HM: Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter. J Biol Chem 280: 35579-35587, 2005
38. Napierala D, Garcia-Rojas X, Sam K, Wakui K, Chen C, Mendoza-Londono R, Zhou G, Zheng Q, Lee B: Mutations and promoter SNPs in RUNX2, a transcriptional regulator of bone formation. Mol Genet Metab 86: 257-268, 2005