Epileptogenic drugs in a model nervous system: Electrophysiological effects and incorporation into a phospholipid layer

Brain Research

Volumn 1122, Issue 1, 2006, Pages 65-77

  Altrup, Ulrich ^a   Häder, Marc ^a   Cáceres, José Luis Hernández ^b   Malcharek, Stefan ^a   Meyer, Michaela ^a   Galla, Hans Joachim ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b Center of Cybernetic Apply to Medicine   (Cuba)

Author keywords

Drug incorporation in cell membrane; Etomidate; Film balance; Mechanisms of epilepsy; Membrane pollution; Pentylenetetrazol

Indexed keywords

ETOMIDATE; PENTETRAZOLE;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EPILEPTOGENESIS; GANGLION; MEMBRANE DEPOLARIZATION; MEMBRANE TRANSPORT; NERVOUS SYSTEM; NONHUMAN; PACEMAKER; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL; SYNAPTIC POTENTIAL;

ACTION POTENTIALS; ANIMALS; CONVULSANTS; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; EPILEPSY; ETOMIDATE; EXCITATORY POSTSYNAPTIC POTENTIALS; GANGLIA, INVERTEBRATE; HELIX (SNAILS); INHIBITORY POSTSYNAPTIC POTENTIALS; MEMBRANE LIPIDS; MEMBRANE POTENTIALS; MODELS, NEUROLOGICAL; NEURONS; PATCH-CLAMP TECHNIQUES; PENTYLENETETRAZOLE; PHOSPHOLIPIDS;

HELIX POMATIA;

EID: 33750710405     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.09.021     Document Type: Article

References (52)

1. Altrup U. Inputs and outputs of giant neurons B1 and B2 in the buccal ganglia of Helix pomatia. Brain Res. 414 (1987) 271-284
2. Altrup U. Epileptogenicity and epileptic activity: mechanisms in an invertebrate model nervous system. Curr. Drug Targets 5 (2004) 473-484
3. Altrup U., and Speckmann E.-J. Identified neuronal individuals in the buccal ganglia of Helix pomatia. Neurosci. Behav. Physiol. 24 (1994) 23-32
4. Altrup U., and Wiemann M. Paroxysmal depolarization shifts (PDS) induce non-synaptic responses in neighboured neurons (buccal ganglia, Helix pomatia). Brain Res. 972 (2003) 186-196
5. Altrup U., Lehmenkühler A., Madeja M., and Speckmann E.-J. Morphology and function of the identified neuron B3 in the buccal ganglia of Helix pomatia. Comp. Biochem. Physiol. 97A (1990) 65-74
6. Altrup U., Lehmenkühler A., and Speckmann E.-J. Effects of the hypnotic drug etomidate in a model nervous system (buccal ganglia, Helix pomatia). Comp. Biochem. Physiol. 99C (1991) 579-587
7. Altrup U., Häder M., and Storz U. Endogenous pacemaker potentials develop into paroxysmal depolarization shifts (PDS) with application of an epileptogenic drug. Brain Res. 975 (2003) 73-84
8. Altrup U., Üre A., and Joschko A. Continuous increase of epileptogenic effects following application of proteolytic enzymes (buccal ganglia of Helix pomatia). Acta Biol. Hung. 55 (2004) 269-272
9. Bakardjieva A., Galla H.-J., and Helmreich E.J.M. Modulation of the β-receptor adenylate cyclase interactions in cultured chang liver cells by membrane fluidization. Biochemistry 18 (1979) 3016-3023
10. Bal T., and McCormick D.A. Mechanisms of oscillatory activity in guinea-pig nucleus reticularis thalami in vitro: a mammalian pacemaker. J. Physiol. 468 (1993) 669-691
11. Baraban S.C., and Schwartzkroin P.A. Electrophysiology of CA1 pyramidal neurons in an animal model of neuronal migration disorders: prenatal methylazoxymethanol treatment. Epilepsy Res. 22 (1995) 145-156
12. Beurer G., and Galla H.J. Anesthetic-phospholipid-interaction: the effect of chlorpromazine on phospholipid monolayers. Eur. Biophys. J. 14 (1987) 403-408
13. Bikson M., Ghai R.S., Baraban S.C., and Durand D.M. Modulation of burst frequency, duration, and amplitude in the zero-Ca(2+) model of epileptiform activity. J. Neurophysiol. 82 (1999) 2262-2270
14. Bond E.F. Channelopathies: potassium-related periodic paralyses and similar disorders. AACN Clin. Issues 11 (2000) 261-270
15. Chalazonitis N., and Boisson M. Abnormal Neuronal Discharges (1978), Raven Press, New York
16. De Deyn P.P., Marescau B., and MacDonald R.L. Epilepsy and the GABA-hypothesis, a brief review and some examples. Acta Neurol. Belg. 90 (1990) 65-81
17. Delgado-Escueta A.V., Wilson W.A., Olsen R.W., and Porter R.J. Jasper's basic mechanisms of the epilepsies. Adv. Neurol. vol. 79 (1999), Lippincott, Williams and Wilkins, Philadelphia
18. Fehér O., Erdélyi L., and Papp A. The effect of pentylenetetrazol on the metacerebral neuron of Helix pomatia. Gen. Physiol. Biophys. 7 (1988) 505-516
19. Feng Z., and Durand D.M. Suppression of excitatory synaptic transmission can facilitate low-calcium epileptiform activity in the hippocampus in vivo. Brain Res. 1030 (2004) 57-65
20. Galla H.J., and Trudell J.R. Asymmetric antagonistic effects of an inhalation anesthetic and high pressure on the phase transition temperature of dipalmitoyl-phosphatidic acid. Biochim. Biophys. Acta 599 (1980) 336-340
21. Galla H.J., and Trudell J.R. Pressure-induced changes in the molecular organization of a lipid-peptide complex: polymyxin binding to phosphatidic acid membranes. Biochim. Biophys. Acta 602 (1980) 522-530
22. Ghaly R.F., Leem J.J., Ham JH., Stone J.L., George S., and Raccforte P. Etomidate dose-response on somatosensory and transcranial magnetic induced spinal motor evoked potentials in primates. Neurol. Res. 21 (1999) 714-720
23. Haarmeier T., Altrup U., and Speckmann E.-J. Attenuation of a voltage-dependent sodium current by GABA (identified neurons, buccal ganglia, Helix pomatia). Brain Res. 663 (1994) 131-139
24. Hartung K., and Hermann A. Differential effects of pentylenetetrazol on ion currents of Aplysia neurones. Brain Res. 419 (1987) 55-64
25. Hodgkin A.L., and Huxley A.F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. 117 (1952) 500-544
26. Jin W., Sugaja A., Tsuda T., Ohguchi H., and Sugaja E. Relationship between large conductance calcium activated potassium channel and bursting activity. Brain Res. 860 (2000) 21-28
27. Kandel E.R., Schwartz J.H., and Jessel T.M. Principles of Neural Science (2000), McGraw-Hill, Columbus
28. Klugbauer N., Marais E., and Hofmann F.J. Calcium channel alpha (2) delta subunits-Structure and Gabapentin binding. Bioenerg. Biomembr. 35 (2003) 639-647
29. Luthman J., and Humpel C. Pentylenetetrazol kindling decreases N-methyl-d-aspartate and kainate but increases gamma-aminobutyric acid-A receptor binding in discrete rat brain areas. Neurosci. Lett. 239 (1997) 9-12
30. Madeja M., Altrup U., and Speckmann E.-J. Synchronization of epileptic discharges: temporal coupling of paroxysmal depolarizations in the buccal ganglia of Helix pomatia. Comp. Biochem. Physiol. 94C (1989) 585-590
31. Madeja M., Muβhoff U., Kuhlmann D., and Speckmann E.-J. Membrane currents elicited by the epileptogenic drug pentylenetetrazol in the native oocyte of Xenopus laevis. Brain Res. 553 (1991) 27-32
32. Nelson L., and Delgado-Escueta A.V. Fluidity of normal and epileptogenic freeze lesioned synaptic membranes in the cat. Brain Res. 386 (1986) 32-40
33. Pacheco M.F., Fowler J.C., and Partridge L.D. The site of action for the convulsant effect of pentylenetetrazol. Comp. Biochem. Physiol. 68C (1981) 99-102
34. Pavlovsky L., Seiffert E., Heinemann U., Korn A., Golan H., and Friedman A. Persistent BBB-disruption may underlie alpha interferon-induced seizures. J. Neurol. 252 (2005) 42-46
35. Peters M., and Altrup U. Motor organization in pharynx of Helix pomatia. J. Neurophysiol. 52 (1984) 389-409
36. Redecker C., Altrup U., Hoppe D., Düsing R., and Speckmann E.-J. Effects of valproate derivatives. I. Antiepileptic efficacy of amides, structural analogs and esters. Neuropharmacology 39 (2000) 254-266
37. Ris L., Capron B., Vibert N., Vida P.-P., and Godaux E. Modification of pacemaker activity of vestibular neurons in brainstem slices during vestibular compensation in the guinea pig. Eur. J. Neurosci. 13 (2001) 2234-2240
38. Ruethrich H., Grecksch G., Becker A., and Krug M. Potentiation effects in the dentate gyrus of pentylenetetrazol-kindled rats. Physiol. Behav. 60 (1996) 455-462
39. Schulze-Bonhage A., Wiemann M., Altrup U., Wittkowski W., and Speckmann E.-J. Epileptic discharges induced by pentylenetetrazol: ultrastructural alterations in identified neurons and glial cells (Helix pomatia). Epilepsy Res. 22 (1995) 23-34
40. Segal M.J. Epileptiform activity in micro cultures containing one hippocampal neuron. J. Neurophysiol. 65 (1991) 761-770
41. Scheibel A.B. Morphological correlates of epilepsy: cells in the hippocampus. Adv. Neurol. 27 (1980) 49-61
42. Sloan T.B. Anesthetic effects on electrophysiologic recordings. J. Clin. Neurophysiol. 15 (1998) 217-226
43. Smith B.N., and Dudek F.E. Short- and long-term changes in CA1 network excitability after kainate treatment in rats. J. Neurophysiol. 85 (2001) 1-9
44. Speckmann E.-J., and Caspers H. Paroxysmal depolarization and changes in action potentials in isolated neurons of Helix pomatia. Epilepsia 14 (1973) 397-408
45. Sugaja E., Onozuka M., Furuichi H., and Sugaja A. Intramembranous particle changes during pentylenetetrazol induced bursting activity in snail neurons. Experientia 37 (1981) 1081-1083
46. Surtees R. Inherited ion channel disorders. Eur. J. Pediatr. 159 (2000) S199-S203
47. Tangorra A., Curatola G., and Bertoli E. Evaluation of antiepileptic drug effect on membrane fluidity. Exp. Mol. Pathol. 55 (1991) 180-189
48. Ward A.A. Missing pieces in the epilepsy puzzle. Appl. Neurophysiol. 48 (1985) 384-394
49. Wiemann M., Altrup U., and Speckmann E.-J. A method to study the effects of an epileptic focus on non-epileptic nervous tissue. J. Neurosci. Methods 68 (1996) 137-141
50. Wiemann M., Jones D., Straub H., Altrup U., and Speckmann E.-J. Simultaneous blockade of intracellular calcium increases and of neuronal epileptiform depolarizations by verapamil. Brain Res. 734 (1996) 49-54
51. Wong R.K.S., and Schwartzkroin P.A. Pacemaker neurons in the mammalian brain: mechanisms and function. In: Carpenter D.O. (Ed). Cellular Pacemakers: Vol. 1. Mechanisms of Pacemaker Generation Vol. 1 (1982), John Wiley, New York 237-254
52. Wua Y.J., and Dworetzky S.I. Recent developments on KCNQ potassium channel opener. Curr. Med. Chem. 12 (2005) 453-460