Evidence that GABA ρ subunits contribute to functional ionotropic GABA receptors in mouse cerebellar Purkinje cells

Journal of Physiology

Volumn 577, Issue 1, 2006, Pages 127-139

  Harvey, Victoria L ^b   Duguid, Ian C ^c   Krasel, Cornelius ^a   Stephens, Gary J ^a,b  

^a UNIVERSITY OF READING   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

(1,2,5,6 TETRAHYDROPYRIDIN 4 YL)METHYLPHOSPHINIC ACID; 1 [2 (BENZHYDRYLIDENEAMINOOXY)ETHYL] 1,2,5,6 TETRAHYDRO 3 PYRIDINECARBOXYLIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOCROTONIC ACID; BICUCULLINE; IONOTROPIC RECEPTOR; METHYLPHOSPHONIC ACID; PHOSPHINIC ACID DERIVATIVE; PROTEIN SUBUNIT; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID C RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR RHO; GABA TRANSPORTER 1; RECEPTOR SUBUNIT; SNAP 5114;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATTENUATION; BINDING AFFINITY; BRAIN ELECTROPHYSIOLOGY; CELLULAR DISTRIBUTION; CEREBELLUM CORTEX; CONTROLLED STUDY; DESENSITIZATION; EVOKED RESPONSE; GABAERGIC TRANSMISSION; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; INTERNEURON; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PURKINJE CELL; SENSITIVITY ANALYSIS; SYNAPTIC TRANSMISSION; CEREBELLAR SLICE; COMPLEX FORMATION; CONCENTRATION RESPONSE; DENDRITE; INHIBITORY POSTSYNAPTIC POTENTIAL; MEMBRANE CONDUCTANCE; NERVE CELL INHIBITION; PROTEIN SUBUNIT; SYNAPSE;

ANIMALS; CELLS, CULTURED; CEREBELLUM; EVIDENCE-BASED MEDICINE; GAMMA-AMINOBUTYRIC ACID; MALE; MICE; NEURAL INHIBITION; PROTEIN SUBUNITS; PURKINJE CELLS; RECEPTORS, GABA; SYNAPTIC TRANSMISSION;

EID: 33750699585     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2006.112482     Document Type: Article

References (40)

1. Alakuijala A, Talvioja K, Pasternack A & Pasternack M (2005). Functional characterization of rat ρ2 subunits expressed in HEK 293 cells. Eur J Neurosci 21, 692-700.
2. Barnard EA, Skolnick P, Olsen RW, Mohler H, Sieghart W, Biggio G, Braestrup C, Bateson AN & Langer SZ (1998). International Union of Pharmacology. XV. Subtypes of γ-aminobutyric acid A receptors: classification on the basis of subunit structure and receptor function. Pharmacol Rev 50, 291-313.
3. Bormann J (2000). The 'ABC'of GABA receptors. Trends Pharmacol Sci 21, 16-19.
4. Boue-Grabot E, Roudbaraki M, Bascles L, Tramu G, Bloch B & Garret M (1998). Expression of GABA receptor ρ subunits in rat brain. J Neurochem 70, 899-907.
5. Chavas J & Marty A (2003). Coexistence of excitatory and inhibitory GABA synapses in the cerebellar interneuron network. J Neurosci 23, 2019-2031.
6. Chiu CS, Brickley S, Jensen K, Southwell A, Mckinney S, Cull-Candy S, Mody I & Lester HA (2005). GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum. J Neurosci 25, 3234-3245.
7. Didelon F, Sciancalepore M, Savic N, Mladinic M, Bradbury A & Cherubini E (2002). γ-Aminobutyric acid A ρ receptor subunits in the developing rat hippocampus. J Neurosci Res 67, 739-744.
8. Drew CA, Johnston GA & Weatherby RP (1984). Bicuculline-insensitive GABA receptors: Studies on the binding of (-)-baclofen to rat cerebellar membranes. Neurosci Lett 52, 317-321.
9. Ekema GM, Zheng W & Lu L (2002). Interaction of GABA receptor/ channel ρ1 and γ2 subunit. Invest Ophthalmol Vis Sci 43, 2326-2333.
10. Engelman HS & MacDermott AB (2004). Presynaptic ionotropic receptors and control of transmitter release. Nat Rev Neurosci 5, 135-145.
11. Farrant M & Nusser Z (2005). Variations on an inhibitory theme: phasic and tonic activation of GABA A receptors. Nat Rev Neurosci 6, 215-229.
12. Fischer H, Harper AA, Anderson CR & Adams DJ (2005). Developmental changes in expression of GABA A receptor-channels in rat intrinsic cardiac ganglion neurones. J Physiol 564, 465-474.
13. Fritschy JM & Mohler H (1995). GABA A -receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits. J Comp Neurol 359, 154-194.
14. Fritschy JM, Panzanelli P, Kralic JE, Vogt KE & Sassoe-Pognetto M (2006). Differential dependence of axo-dendritic and axo-somatic GABAergic synapses on GABA A receptors containing the α1 subunit in Purkinje cells. J Neurosci 26, 3245-3255.
15. C receptors. Eur J Pharmacol 497, 139-146.
16. Harvey VL & Stephens GJ (2004). Mechanism of GABA receptor-mediated inhibition of spontaneous GABA release onto cerebellar Purkinje cells. Eur J Neurosci 20, 684-700.
17. Johnston GA (1996). GABA C receptors: Relatively simple transmitter-gated ion channels? Trends Pharmacol Sci 17, 319-323.
18. Johnston GA, Curtis DR, Beart PM, Game CJ, McCulloch RM & Twitchin B (1975). Cis- and trans-4-aminocrotonic acid as GABA analogues of restricted conformation. J Neurochem 24, 157-160.
19. A conductances in rat neocortex. J Neurophysiol 94, 2073-2085.
20. King JS, Chen YF & Bishop GA (1993). An analysis of HRP-filled basket cell axons in the cat's cerebellum. II. Axonal distribution. Anat Embryol (Berl) 188, 299-305.
21. A receptors in the CNS: Where and why? Prog Biophys Mol Biol 87, 33-46.
22. Kusama T, Spivak CE, Whiting P, Dawson VL, Schaeffer JC & Uhl G (1993). Pharmacology of GABA ρ1 and GABA α/β receptors expressed in Xenopus oocytes and COS cells. Br J Pharmacol 109, 200-206.
23. Llano I, Gonzalez J, Caputo C, Lai FA, Blayney LM, Tan YP & Marty A (2000). Presynaptic calcium stores underlie large-amplitude miniature IPSCs and spontaneous calcium transients. Nat Neurosci 3, 1256-1265.
24. C ρ2 subunit. Molecular evidence of a widespread distribution in the CNS. Neurosci Res 53, 421-427.
25. C receptor subunits in native central neurons. J Neurosci 24, 7241-7250.
26. Pan Y, Khalili P, Ripps H & Qian H (2005). Pharmacology of GABA C receptors: Responses to agonists and antagonists distinguish A- and B-subtypes of homomeric ρ receptors expressed in Xenopus oocytes. Neurosci Lett 376, 60-65.
27. Pan Y & Qian H (2005). Interactions between ρ and γ2 subunits of the GABA receptor. J Neurochem 94, 482-490.
28. Qian H & Ripps H (1999). Response kinetics and pharmacological properties of heteromeric receptors formed by coassembly of GABA ρ and γ2-subunits. Proc R Soc Lond B Biol Sci 266, 2419-2425.
29. Ragozzino D, Woodward RM, Murata Y, Eusebi F, Overman LE & Miledi R (1996). Design and in vitro pharmacology of a selective γ-aminobutyric acid C receptor antagonist. Mol Pharmacol 50, 1024-1030.
30. C receptor ρ1 and ρ2 subunits in developing rat brain and spinal cord. Eur J Neurosci 15, 1747-1758.
31. Semyanov A & Kullmann DM (2002). Relative picrotoxin insensitivity distinguishes ionotropic GABA receptor-mediated IPSCs in hippocampal interneurons. Neuropharmacol 43, 726-736.
32. Semyanov A, Walker MC, Kullmann DM & Silver RA (2004). Tonically active GABA A receptors: Modulating gain and maintaining the tone. Trends Neurosci 27, 262-269.
33. Southan AP & Robertson B (1998). Patch-clamp recordings from cerebellar basket cell bodies and their presynaptic terminals reveal an asymmetric distribution of voltage-gated potassium channels. J Neurosci 18, 948-955.
34. Thompson SA, Whiting PJ & Wafford KA (1996). Barbiturate interactions at the human GABA A receptor: Dependence on receptor subunit combination. Br J Pharmacol 117, 521-527.
35. Turecek R & Trussell LO (2001). Presynaptic glycine receptors enhance transmitter release at a mammalian central synapse. Nature 411, 587-590.
36. Turecek R & Trussell LO (2002). Reciprocal developmental regulation of presynaptic ionotropic receptors. Proc Natl Acad Sci U S A 99, 13884-13889.
37. Wall MJ (2001). Cis-4-amino-crotonic acid activates α6 subunit-containing GABA A but not GABA C receptors in granule cells of adult rat cerebellar slices. Neurosci Lett 316, 37-40.
38. A receptor gene family. Ann N Y Acad Sci 868, 645-653.
39. A receptor diversity. Neuropharmacol 35, 1139-1160.
40. C receptors: A comparison of native versus recombinant receptors. Trends Pharmacol Sci 22, 121-132.