Potential antioxidative effects of cactus pear fruit (Opuntia ficus-indica) extract on radical scavenging and DNA damage reduction in human peripheral lymphocytes

Journal of Food Lipids

Volumn 13, Issue 4, 2006, Pages 445-458

  Siriwardhana, Nalin ^a   Shahid, Fereidoon ^b   Jeon, You Jin ^a  

^a Jeju National University   (South Korea)

^b MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CACTACEAE; OPUNTIA; OPUNTIA FICUS-INDICA; PYRUS COMMUNIS;

EID: 33750698589     PISSN: 10657258     EISSN: 17454522     Source Type: Journal    
DOI: 10.1111/j.1745-4522.2006.00065.x     Document Type: Article

References (35)

1. ATUKORALA, Y., LEE, K. W., SONG, C., AHN, C.B., SHIN, T.S., CHA, Y.J., SHAHIDI,F. and JEON, Y.J. 2003. Potential antioxidant activity of marine red alga grateloupia filicina extracts. J. Food Lipids 10, 251-265.
2. BRAND, M.D. 2000. Uncoupling to survive? The role of mitochondrial inefficiency in aging. Exper. Gerotol. 35, 811-820.
3. BUYUKOKUROGLU, M.E., GULCIN, I., OKTAY, M. and KUFREVIOGLU, O.I. 2001. In vitro antioxidant properties of dantrolene sodium. Pharmacol. Res. 44(6), 184-191.
4. CHEESEMAN, K.H. and SLATER, T.F. 1993. An introduction to free radical biochemistry. Brit. Med. Bull. 49, 481-493.
5. DOK-GO, H., LEE, K.H., KIM, H.J., LEE, E.H., LEE, J., SONG, Y.S., LEE, Y.H., JIN, C., LEE, Y.S. and CHO, J. 2003. Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten. Brain Res. 965, 130-136.
6. ESCRIBANO, J., PERENO, M.A., GARCIA-CARMONA, F. and MUNOZ, R. 1998. Characterazation of the antiradical activity of betalains from Beta vulgaris L. roots. Phytochemistry 9, 124-127.
7. FRIDOVICH, I. 1998. Oxygen toxicity: A radical explanation. J. Exp. Biol. 207, 1203-1209.
8. GALATI, E.M., MONFORTE, M.T., TRIPODO, M.M., AQUINO, A. and MONDELLO, M.R. 2001. Antiulcer activity of Opuntia ficus-indica (L.) Mill. (Cactaeceae): Ultrastructural study. J. Ethnopharmacol. 76, 1-9.
9. GLEI, M., LIEGIBEL, U.M., EBERT, M.N., BOHM, V. and POOL-ZOBEL, B.L. 2002. Beta-carotene reduces bleomycin-induced genetic damage in human lymphocytes. Toxicol. Appl. Pharmacol. 179, 65-73.
10. GULCIN, I., BUYUKOKUROGLU, M.E., OKTAY, M. and KUFREVIOGLU, O.I. 2003. Antioxidant and analgesic activities of turpentine of Pinus nigra Arn. subsp. Pallsiana (Lamb). J. Ethnopharmacol. 86, 51-58.
11. GURBACHAN, S. and FELKER, P. 1998. Cactus: New world foods. Ind. Hortic. 43, 29-31.
12. HALLIWEILL, B. 1991. Reactive oxygen species in living systems. Biochemistry, and role in human diseases. Am. J. Med. 91(3), 14-19.
13. HALLIWELL, B. and GUTTERIDGE, J.M.C. 1990. Role of free radicals and catalytic metal ions in human diseases: An overview. Methods Enzymol. 186, 1-85.
14. HIRAMOTO, K., JOHKOH, H., SAKO, K. and KIKUGAWA, K. 1993. DNA breaking activity of the carbon-centered radical generated from 2,2-azobis(2- amidinopropane) hydrochloride (AAPH). Free Radical Res. Commun. 19, 323-332.
15. IMAMURA, A. and HIRAO, K. 1979. A molecular orbital approach to the eletrophilicity of H and OH radical. Bull. Chem. Soc. Jpn. 52(2), 287-292.
16. KEHRER, J.P. 1993. Free radicals as mediators of tissue injury and disease. Crit. Rev. Toxicol. 23, 21-48.
17. 2+). J. Phys. Chem. 88, 99-101.
18. KOUROUNAKIS, A., GALANAKIS, D., REKKA, E. and KOUROUNAKIS, P. 1998. Synthesis and evaluation of novel derivatives of antiinflammatory drugs with increased antioxidant and anti-inflammatory activities. Drug Dev. Res. 46, 9-16.
19. LEE, N.H., YOON, J.S., LEE, B.H., CHOI, B.W. and PARK, K.H. 2000. Screening of the radical scavenging effects, tyrosinase inhibition, and anti-allergic activities using Opuntia ficus-indica. Kor. J. Pharmacogn. 31, 412-415.
20. LUI, F. and NG, T.B. 2000. Antioxidative and free radical scavenging activities of selected medicinal herbs. Life Sci. 66(8), 725-735.
21. NANJO, F., GOTO, K., SETO, R., SUZUKI, H., SAKAI, M. and HARA, Y. 1996. Scavenging effects of tea catechins and their derivatives on 1,1-diphenyl-2-picrylhydrazyl radical. Free Radical Biol. Med. 21, 885-902.
22. NORDBERG, J. and ARNER, E.S.J. 2001. Reactive oxygen species, antioxidants and the mammalian thioredoxin system. Free Radical Biol. Med. 31, 1287-1312.
23. PARK, H.E., KAHNG, J.A., LEE, H.S. and SHIN, K.H. 2001. An antiinflammatory principle from cactus. Fitoterapia 72, 228-290.
24. PEDRENO, M.A. and ESCRIBANO, J. 2000. Studying the oxidation and the antiradical activity of betalain from beetroot. J. Biol. Educ. 35(1), 49-51.
25. ROSEN, G.M. and RAUKMAN, E.J. 1980. Spin trapping of the primary radical involved in the activation of the carcinogen N-hydroxy-2-acetylaminofluorene by cumene hydroperoxide-hematin. Mol. Pharmacol. 17, 233-238.
26. RUSSEL, C.H. and FELKER, P. 1987. The prickly pears (Opuntia spp. Cactaceae). A source of human and animal food in semiarid regions. Econ. Bot. 41, 433-445.
27. SANCHEZ-MORENO, C. 2002. Methods used to evaluate the free radical scavenging activity in foods and biological systems. Food Sci. Technol. Int. 8(3), 121-137.
28. SINGH, P.N., MCCOY, M.T., TICE, R.R. and SCHNEIDERM, E.L. 1988. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175, 184-191.
29. SIRIWARDHANA, N. and JEON, Y.J. 2004. Antioxidative effect of cactus pear fruit (Opuntia ficus-indica) extract on lipid peroxidation inhibition in oils and emulsion model systems. Eur. Food Res. Technol. 219, 369-376.
30. SIRIWARDHANA, N., LEE, K.W., KIM, S.H., HA, J.W. and JEON, Y.J. 2003. Antioxidant activity of Hizikia fusiformis on reactive oxygen species scavenging and lipid peroxidation inhibition. Food Sci. Technol. Int. 9, 339-346.
31. STINTZING, F.C., SCHIEBER, A. and CARLE, R. 2000. Phytochemical and nutritional significance of cactus pear. Food Res. Technol. Int. 212, 396-407.
32. STRACK, D., VOGT, T. and SCHLIEMANN, W. 2003. Recent advances in betalain research. Phytotechnol. 62, 247-269.
33. TESORIERE, L., BUTERA, D., ARPA, D., DI GAUDIO, F., ALLEGRA, M., GENTILE, C. and LIVREA, M.A. 2003. Increased resistance to oxidation of betalain-enriched human low density lipoproteins. Free Radical Res. 37, 689-696.
34. WIE, M.B. 2000. Protective effects of Opuntia ficus-indica and Saururus Chinensis on free-radical induced neuronal injury in mouse cortical cell cultures. Yakhak Hoiji 44, 613-619.
35. ZIN, Z.M., HAMID, A.A. and OSMAN, A. 2002. Antioxidative activity of extracts from Mengkudu (Morinda citrifolia L.) root, fruit and leaf. Food Chem. 78, 227-231.