Animal models/tests of drug addiction: A quest for the holy grail, or the pursuit of wild geese?

Addiction Biology

Volumn 11, Issue 1, 2006, Pages 39-42

  Stephens, David N ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTATION; ALCOHOL CONSUMPTION; AMYGDALOID NUCLEUS; ANIMAL BEHAVIOR; ANIMAL MODEL; COCAINE DEPENDENCE; CONDITIONING; DRUG DEPENDENCE; IMPULSIVENESS; MOLECULAR MECHANICS; MOTIVATION; NEUROBIOLOGY; NONHUMAN; NOTE; PRIORITY JOURNAL; REINFORCEMENT; RESEARCH; REWARD; SENSITIZATION; ADDICTION; ALCOHOLISM; ANIMAL; DISEASE MODEL; PSYCHOLOGICAL ASPECT; RODENT; WITHDRAWAL SYNDROME;

ALCOHOLISM; ANIMALS; CONDITIONING (PSYCHOLOGY); DISEASE MODELS, ANIMAL; MOTIVATION; REWARD; RODENTIA; SUBSTANCE WITHDRAWAL SYNDROME; SUBSTANCE-RELATED DISORDERS;

EID: 33750684316     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/j.1369-1600.2006.00010.x     Document Type: Note

References (22)

1. Avena NM, Carrillo CA, Needham L, Leibowitz SF, Hoebel BG (2004) Sugar-dependent rats show enhanced intake of unsweetened ethanol. Alcohol 34 : 203 209.
2. Bindra D (1968) Neuropsychological interpretation of the effects of the drive and incentive-motivation on general activity and instrumental behavior. Psychol Rev 75 : 1 22.
3. Borlikova G, Elbers N, Stephens DN (2006) Repeated withdrawal from ethanol spares contextual fear conditioning and spatial learning but impairs negative patterning and induces over-responding: evidence for effect on frontal cortical but not hippocampal function? Eur J Neurosci (in press).
4. Colantuoni C, Schwenker J, McCarthy J, Rada P, Ladenheim B, Cadet JL, Schwartz GJ, Moran TH, Hoebel BG (2001) Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain. Neuroreport 12 : 3549 3552.
5. Crombag HS, Badiani A, Robinson TE (1996) Signalled versus unsignalled intravenous amphetamine: large differences in the acute psychomotor response and sensitization. Brain Res 722 : 227 231.
6. Duka T, Townshend JM, Collier K, Stephens DN (2003) Impairment in cognitive functions after multiple detoxifications in alcoholic inpatients. Alcohol Clin Exp Res 27 : 1563 1572.
7. Everitt BJ, Robbins TW (2005) Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci 8 : 1481 1489.
8. Heyne A (1996) The development of opiate addiction in the rat. Pharmacol Biochem Behav 53 : 11 25.
9. Heyne A, Wolffgramm J (1998) The development of addiction to d-amphetamine in an animal model: same principles as for alcohol and opiate. Psychopharmacology (Berl) 140 : 510 518.
10. Kirby K, Petri N (2004) Heroin addicts and cocaine abusers have higher discounting rates for delayed rewards than alcoholics or non-drug controls. Addiction 99 : 467 471.
11. Koob GF, Le Moal M (2001) Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 24 : 97 129.
12. Robinson TE, Berridge KC (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 18 : 247 291.
13. Robinson TE, Berridge KC (2001) Incentive-sensitization and addiction. Addiction 96 : 103 114.
14. Sanchis-Segura C, Spanagel R (2006) Behavioural assessment of drug-reinforcement and addictive features in rodents: an overview. Addict Biol 11 : 2 38.
15. Sheffield FD, Campbell BA (1954) The role of experience in the spontaneous activity of hungry rats. J Comp Physiol Psychol 47 : 97 100.
16. Stephens DN, Mead AN (2004) Behavioural plasticity-induced changes in drug response. Commentary on Badiani and Robinson drug-induced neurobehavioral plasticity: the role of environmental context. Behav Pharmacol 15 : 377 380.
17. Stewart J (1983) Conditioned and unconditioned drug effects in relapse to opiate and stimulant drug self-administration. Prog Neuropsychopharmacol Biol Psychiatry 7 : 591 597.
18. Stewart J, de Wit H, Eikelboom R, eds. (1984) Role of Unconditioned and Conditioned Drug Effects in the Self-Administration of Opiates and Stimulants. 91 : 251 268.
19. Stewart J, Vezina P (1988) A comparison of the effects of intra-accumbens injections of amphetamine and morphine on reinstatement of heroin intravenous self-administration behavior. Brain Res 457 : 287 294.
20. Vezina P, Giovino AA, Wise RA, Stewart J (1989) Environment-specific cross-sensitization between the locomotor activating effects of morphine and amphetamine. Pharmacol Biochem Behav 32 : 581 584.
21. Vezina P, Stewart J (1984) Conditioning and place-specific sensitization of increases in activity induced by morphine in the VTA. Pharmacol Biochem Behav 20 : 925 934.
22. Volkow ND, Wise RA (2005) How can drug addiction help us understand obesity? Nat Neurosci 8 : 555 560.