Effects of flufenamic acid on fictive locomotion, plateau potentials, calcium channels and NMDA receptors in the lamprey spinal cord

Neuropharmacology

Volumn 51, Issue 6, 2006, Pages 1038-1046

  Wang, Di ^a   Grillner, Sten ^a   Wallén, Peter ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Central pattern generator; ICAN; Membrane potential oscillations; Network; NMDA

Indexed keywords

APAMIN; CALCIUM CHANNEL; CALCIUM CHELATING AGENT; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; FLUFENAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; POTASSIUM CHANNEL BLOCKING AGENT;

AFTERHYPERPOLARIZATION; AMPLITUDE MODULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; DEPOLARIZATION; DRUG EFFECT; EXCITATORY POSTSYNAPTIC POTENTIAL; EXPERIMENTATION; FEMALE; INTRACELLULAR SPACE; LAMPREY; LOCOMOTION; MALE; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; RETICULOSPINAL TRACT; SPINAL CORD; SPINAL CORD NERVE CELL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APAMIN; CALCIUM CHANNELS; CALCIUM SIGNALING; CHELATING AGENTS; EGTAZIC ACID; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID AGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; FEMALE; FLUFENAMIC ACID; GAP JUNCTIONS; LAMPREYS; LOCOMOTION; MALE; MEMBRANE POTENTIALS; N-METHYLASPARTATE; POTASSIUM CHANNEL BLOCKERS; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD; SYNAPTIC TRANSMISSION;

EID: 33750630565     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2006.06.012     Document Type: Article

References (30)

1. Brodin L., and Grillner S. Effects of magnesium on fictive locomotion induced by activation of N-methyl-d-aspartate (NMDA) receptors in the lamprey spinal cord in vitro. Brain Res. 380 (1986) 244-252
2. Brodin L., Grillner S., Dubuc R., Ohta Y., Kasicki S., and Hökfelt T. Reticulospinal neurons in lamprey: transmitters, synaptic interactions and their role during locomotion. Arch. Ital. Biol. 126 (1988) 317-345
3. Bruzzone R., Barbe M.T., Jakob N.J., and Monyer H. Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes. J. Neurochem. 92 (2005) 1033-1043
4. Ca channels for reticulospinal synaptic transmission to motoneuron and for the afterhyperpolarization. J. Neurophysiol. 88 (2002) 289-299
5. Chen Q., Olney J.W., Lukasiewicz P.D., Almli T., and Romano C. Fenamates protect neurons against ischemic and excitotoxic injury in chick embryo retina. Neurosci. Lett. 242 (1998) 163-166
6. Congar P., Leinekugel X., Ben-Ari Y., and Crepel V. A long-lasting calcium-activated nonselective cationic current is generated by synaptic stimulation or exogenous activation of group I metabotropic glutamate receptors in CA1 pyramidal neurons. J. Neurosci. 17 (1997) 5366-5379
7. El Manira A., Tegnér J., and Grillner S. Calcium-dependent potassium channels play a critical role for burst termination in the locomotor network in lamprey. J. Neurophysiol. 72 (1994) 1852-1861
8. Fraser D.D., and MacVicar B.A. Cholinergic-dependent plateau potential in hippocampal CA1 pyramidal neurons. J. Neurosci. 16 (1996) 4113-4128
9. Grillner S., McClellan A., Sigvardt K., Wallén P., and Wilén M. Activation of NMDA-receptors elicits "fictive locomotion" in lamprey spinal cord in vitro. Acta Physiol. Scand. 113 (1981) 549-551
10. Grillner S., Wallén P., Hill R., Cangiano L., and El Manira A. Ion channels of importance for the locomotor pattern generation in the lamprey brainstem-spinal cord. J. Physiol. 533 (2001) 23-30
11. Grillner S. The motor infrastructure: from ion channels to neuronal networks. Nature Rev. Neurosci. 4 (2003) 573-586
12. Harks E.G., de Roos A.D., Peters P.H., de Haan L.H., Brouwer A., Ypey D.L., van Zoelen E.J., and Theuvenet A.P. Fenamates: a novel class of reversible gap junction blockers. J. Pharmacol. Exp. Ther. 298 (2001) 1033-1041
13. Hill R.H., Århem P., and Grillner S. Ionic mechanisms of 3 types of functionally different neurons in the lamprey spinal cord. Brain Res 358 (1985) 40-52
14. Klink R., and Alonso A. Ionic mechanisms of muscarinic depolarization in entorhinal cortex layer II neurons. J. Neurophysiol. 77 (1997) 1829-1843
15. 2+-activated currents in neurons. Cell Calcium 19 (1996) 431-438
16. Lerma J., and Martin del Rio R. Chloride transport blockers prevent N-methyl-d-aspartate receptor-channel complex activation. Mol. Pharmacol. 41 (1992) 217-222
17. Morisset V., and Nagy F. Ionic basis for plateau potentials in deep dorsal horn neurons of the rat spinal cord. J. Neurosci. 19 (1999) 7309-7316
18. Ohta Y., and Grillner S. Monosynaptic excitatory amino acid transmission from the posterior rhombencephalic reticular nucleus to spinal neurons involved in the control of locomotion in lamprey. J. Neurophysiol. 62 (1989) 1079-1089
19. Ottolia M., and Toro L. Potentiation of large conductance KCa channels by niflumic, flufenamic, and mefenamic acids. Biophys. J. 67 (1994) 2272-2279
20. Partridge L.D., Muller T.H., and Swandulla D. Calcium-activated non-selective channels in the nervous system. Brain Res. Rev. 19 (1994) 319-325
21. Pena F., Parkis M.A., Tryba A.K., and Ramirez J.M. Differential contribution of pacemaker properties to the generation of respiratory rhythms during normoxia and hypoxia. Neuron 43 (2004) 105-117
22. Schiller Y. Activation of a calcium-activated cation current during epileptiform discharges and its possible role in sustaining seizure-like events in neocortical slices. J. Neurophysiol. 92 (2004) 862-872
23. Srinivas M., and Spray D.C. Closure of gap junction channels by arylaminobenzoates. Mol. Pharmacol. 63 (2003) 1389-1397
24. Tryba A.K., Pena F., and Ramirez J.M. Gasping activity in vitro: a rhythm dependent on 5-HT2A receptors. J. Neurosci. 26 (2006) 2623-2634
25. Viana Di Prisco G., Pearlstein E., Le Ray D., Robitaille R., and Dubuc R. A cellular mechanism for the transformation of a sensory input into a motor command. J. Neurosci. 20 (2000) 8169-8176
26. Wallén P., and Grillner S. N-methyl-d-aspartate receptor-induced, inherent oscillatory activity in neurons active during fictive locomotion in the lamprey. J. Neurosci. 7 (1987) 2745-2755
27. Wallén P., Grillner S., Feldman J.L., and Bergelt S. Dorsal and ventral myotome motoneurons and their input during fictive locomotion in lamprey. J. Neurosci. 5 (1985) 654-661
28. CAN) may contribute to spinal locomotor pattern generation in lamprey. Soc. Neurosci. Abstr. (2001) 730.2
29. 2+-sensitive non-specific cation channel underlying prolonged repetitive firing in Aplysia neurons. J. Neurosci. 16 (1996) 3661-3671
30. Zhang B., Wootton J.F., and Harris-Warrick R.M. Calcium-dependent plateau potentials in a crab stomatogastric ganglion motor neuron. II. Calcium-activated slow inward current. J. Neurophysiol. 74 (1995) 1938-1946