Oligomeric structure of the α1b-adrenoceptor: Comparisons with rhodopsin

Vision Research

Volumn 46, Issue 27, 2006, Pages 4434-4441

  Milligan, Graeme ^a   Pediani, John D ^a   Canals, Meritxell ^a   Lopez Gimenez, Juan F ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Catecholamine; G protein coupled receptor; Oligomerization; Receptor fragmentation; Resonance energy transfer

Indexed keywords

ADRENERGIC RECEPTOR; ALPHA1B ADRENERGIC RECEPTOR; MEMBRANE PROTEIN; OLIGOMER; RHODOPSIN; UNCLASSIFIED DRUG; ADRENERGIC RECEPTOR ALPHA(1B); ALPHA 1 ADRENERGIC RECEPTOR;

ARTICLE; CELL SURFACE; COMPARATIVE STUDY; DIMERIZATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HYDROPHOBICITY; IMMUNOPRECIPITATION; MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN GLYCOSYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; SIGNAL TRANSDUCTION; ANIMAL; CELL MEMBRANE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; PHOTOTRANSDUCTION; PHYSIOLOGY; RETINA ROD OUTER SEGMENT; REVIEW;

ANIMALS; CELL MEMBRANE; DIMERIZATION; HUMANS; MUTATION; PHOTOTRANSDUCTION; PROTEIN STRUCTURE, QUATERNARY; RECEPTORS, ADRENERGIC, ALPHA-1; RHODOPSIN; ROD OUTER SEGMENTS;

EID: 33750622472     PISSN: 00426989     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.visres.2006.08.007     Document Type: Article

References (34)

1. Adie E., Francis M.J., Davies J., Smith L., Marenghi A., Hather C., et al. CypHer 5-a generic approach for measuring the activation and trafficking of G-protein-coupled receptors in live cells. Assays and Drug Development Technologies 1 (2003) 251-259
2. 1b-adrenoceptor. Molecular Pharmacology 66 (2004) 1123-1137
3. Carrillo J.J., Pediani J., and Milligan G. Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins. Journal of Biological Chemistry 278 (2003) 42578-42587
4. 11. Journal of Pharmacology and Experimental Therapeutics 302 (2002) 1080-1088
5. Davies A., Gowen B.E., Krebs A.M., Schertler G.F., and Saibil H.R. Three-dimensional structure of an invertebrate rhodopsin and basis for ordered alignment in the photoreceptor membrane. Journal of Molecular Biology 314 (2001) 455-463
6. de Juan D., Mellado M., Rodriguez-Frade J.M., Hernanz-Falcon P., Serrano A., Del Sol A., et al. A framework for computational and experimental methods: identifying dimerization residues in CCR chemokine receptors. Bioinformatics 21 Suppl. 2 (2005) ii13-ii18
7. Fotiadis D., Liang Y., Filipek S., Saperstein D.A., Engel A., and Palczewski K. The G protein-coupled receptor rhodopsin in the native membrane. FEBS Letters 564 (2004) 281-288
8. Galperin E., Verkhusha V.V., and Sorkin A. Three-chromophore FRET microscopy to analyse multiprotein interactions in living cells. Nature Methods 1 (2004) 209-217
9. Guo W., Shi L., Filizola M., Weinstein H., and Javitch J.A. Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation. Proceedings of the National Academy of Sciences of the United States of America 102 (2005) 17495-17500
10. Guo W., Shi L., and Javitch J.A. The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer. Journal of Biological Chemistry 278 (2003) 4385-4388
11. Koshimizu T.A., Tanoue A., Hirasawa A., Yamauchi J., and Tsujimoto G. Recent advances in alpha1-adrenoceptor pharmacology. Pharmacology and Therapeutics 98 (2003) 235-244
12. Kota P., Reeves P.J., Rajbhandary U.L., and Khorana H.G. Opsin is present as dimers in COS1 cells: identification of amino acids at the dimeric interface. Proceedings of the National Academy of Sciences of the United States of America 103 (2006) 3054-3059
13. Leterrier C., Bonnard D., Carrel D., Rossier J., and Lenkei Z. Constitutive endocytic cycle of the CB1 cannabinoid receptor. Journal of Biological Chemistry 279 (2004) 36013-36021
14. Leterrier C., Laine J., Darmon M., Boudin H., Rossier J., and Lenkei Z. Constitutive activation drives compartment-selective endocytosis and axonal targeting of type 1 cannabinoid receptors. Journal of Neuroscience 26 (2006) 3141-3153
15. Liang Y., Fotiadis D., Filipek S., Saperstein D.A., Palczewski K., and Engel A. Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes. Journal of Biological Chemistry 278 (2003) 21655-21662
16. Li J., Edwards P.C., Burghammer M., Villa C., and Schertler G.F. Structure of bovine rhodopsin in a trigonal crystal form. Journal of Molecular Biology 343 (2004) 1409-1438
17. 1b-adrenoceptor probed using sequential three color fluorescence resonance energy transfer imaging: effective oligomerization is required for receptor maturation and function, submitted for publication.
18. Mackenzie J.F., Daly C.J., Pediani J.D., and McGrath J.C. Quantitative imaging in live human cells reveals intracellular alpha(1)-adrenoceptor ligand-binding sites. Journal of Pharmacology and Experimental Therapeutics 294 (2000) 434-443
19. Mansoor S.E., Palczewski K., and Farrens D.L. Rhodopsin self-associates in asolectin liposomes. Proceedings of the National Academy of Sciences of the United States of America 103 (2006) 3060-3065
20. Milasta S., Evans N., Ormiston L., Wilson S., Lefkowitz R.J., and Milligan G. The sustainability of interactions between the orexin-1 receptor and β-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAP kinase regulation. Biochemical Journal 387 (2005) 573-584
21. Milligan G. G protein-coupled receptor dimerization: function and ligand pharmacology. Molecular Pharmacology 66 (2004) 1-7
22. Milligan G. Applications of bioluminescence- and fluorescence resonance energy transfer to drug discovery at G protein-coupled receptors'. European Journal of Pharmaceutical Sciences 21 (2004) 397-405
23. Milligan G. The molecular basis of dimerisation of family A G protein-coupled receptors. In: Lundstrom C. (Ed). GPCRs in drug discovery (2005), Marcel Dekker, Inc. 329-340
24. Milligan G., and Bouvier M. Methods to monitor the quaternary structure of G protein-coupled receptors. FEBS Journal 272 (2005) 2914-2925
25. Morris D.P., Price R.R., Smith M.P., Lei B., and Schwinn D.A. Cellular trafficking of human alpha1a-adrenergic receptors is continuous and primarily agonist-independent. Molecular Pharmacology 66 (2004) 843-854
26. Overton M.C., Chinault S.L., and Blumer K.J. Oligomerization, biogenesis, and signaling is promoted by a glycophorin A-like dimerization motif in transmembrane domain 1 of a yeast G protein-coupled receptor. Journal of Biological Chemistry 278 (2003) 49369-49377
27. Palczewski K., Kumasaka T., Hori T., Behnke C.A., Motoshima H., Fox B.A., et al. Crystal structure of rhodopsin: a G protein-coupled receptor. Science 289 (2000) 739-745
28. Pediani J.D., Colston J.F., Caldwell D., Milligan G., Daly C.J., and McGrath J.C. Beta-arrestin-dependent spontaneous alpha1a-adrenoceptor endocytosis causes intracellular transportation of alpha-blockers via recycling compartments. Molecular Pharmacology 67 (2005) 992-1004
29. Petaja-Repo U.E., Hogue M., Laperriere A., Bhalla S., Walker P., and Bouvier M. Newly synthesized human delta opioid receptors retained in the endoplasmic reticulum are retrotranslocated to the cytosol, deglycosylated, ubiquitinated, and degraded by the proteasome. Journal of Biological Chemistry 276 (2001) 4416-4423
30. Pfleger K.D., and Eidne K.A. Illuminating insights into protein-protein interactions using bioluminescence resonance energy transfer (BRET). Nature Methods 3 (2006) 165-174
31. Piascik M.T., and Perez D.M. Alpha1-adrenergic receptors: new insights and directions. Journal Pharmacology and Experimental Therapeutics 298 (2001) 403-410
32. Stanasila L., Perez J.B., Vogel H., and Cotecchia S. Oligomerization of the alpha 1a- and alpha 1b-adrenergic receptor subtypes. Potential implications in receptor internalization. Journal of Biological Chemistry 278 (2003) 40239-40251
33. Uberti M.A., Hall R.A., and Minneman K.P. Subtype-specific dimerization of alpha 1-adrenoceptors: effects on receptor expression and pharmacological properties. Molecular Pharmacology 64 (2003) 1379-1390
34. Zeng F.Y., and Wess J. Identification and molecular characterization of m3 muscarinic receptor dimers. Journal of Biological Chemistry 274 (1999) 19487-19497