Fusion of chemotactic peptide to a single-chain bi-specific antibody (scBsAb) potentiates its cytotoxicity to target tumour cells

Biotechnology and Applied Biochemistry

Volumn 45, Issue 3, 2006, Pages 147-154

  Song, Jingzhen ^a,b   Wang, Xiangbin ^c   Lei, Chun ^a,c   Piao, Jinhua ^c   Yin, Changcheng ^c   Zhang, Zhong ^c   Lin, Qing ^a,c   Huang, Hualiang ^a,c  

^a INSTITUTE OF GENETICS AND DEVELOPMENTAL BIOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c Beijing ABT Genetic Engineering Technology Co Ltd   (China)

Author keywords

Bi specific antibody; Chemotactic peptide; Cytotoxicity; Ovarian carcinoma; Peripheral blood lymphocyte; Tumour specific cytolysis

Indexed keywords

ANTIBODIES; CARCINOGENS; CELLS; ESCHERICHIA COLI; TOXICITY; TUMORS;

BI-SPECIFIC ANTIBODY; BLOOD LYMPHOCYTES; CHEMOTACTIC PEPTIDES; OVARIAN CARCINOMA;

ONCOLOGY;

2 DIETHYLAMINOETHANOL; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BISPECIFIC ANTIBODY; BISPECIFIC ANTIBODY 18TBHL; CANCER ANTIBODY; CHEMOTACTIC PEPTIDE; HYBRID PROTEIN; SECONDARY LYMPHOID TISSUE CHEMOKINE; UNCLASSIFIED DRUG;

ANION EXCHANGE CHROMATOGRAPHY; ANTIBODY AFFINITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNOTHERAPY; CELL KILLING; CHEMOTAXIS; CYTOLYSIS; CYTOTOXICITY; DRUG ACTIVITY; DRUG BINDING; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMOBILIZED METAL AFFINITY CHROMATOGRAPHY; NONHUMAN; OVARY CARCINOMA; PERIPHERAL LYMPHOCYTE; PROTEIN BINDING; REGULATORY T LYMPHOCYTE;

ANTIBODIES, BISPECIFIC; APOPTOSIS; CHEMOKINES, CC; CHEMOTAXIS; CYTOTOXICITY, IMMUNOLOGIC; DRUG DELIVERY SYSTEMS; DRUG SYNERGISM; FEMALE; HUMANS; MEMBRANE FUSION PROTEINS; OVARIAN NEOPLASMS; PEPTIDE FRAGMENTS; T-LYMPHOCYTES; TUMOR CELLS, CULTURED;

ESCHERICHIA COLI;

EID: 33750608847     PISSN: 08854513     EISSN: None     Source Type: Journal    
DOI: 10.1042/BA20060060     Document Type: Article

References (45)

1. Withoff, S., Helfrich, W., de Leij, L. F. and Molema, G. (2001) Curr. Opin. Mol. Ther. 3, 53-62
2. Manzke, Q., Tesch, H., Lorenzen, J., Diehl, V. and Bohlen, H. (2001) Int J. Cancer 91, 516-522
3. Rousseau, R. F., Haight A. E., Hirschmann-Jax, C., Yvon, E. S., Rill, D. R.. Mei, Z., Smith, S. C., Inman, S., Cooper K., Alcoser, P. et al. (2003) Blood 101, 1718-1726
4. Schoonjans, R., Willems, A., Schoonooghe, S., Leoen, J., Grooten, J. and Mertens, N. (2001) Biomol. Eng. 17, 193-202
5. Liu, J., Zhao, O., Zhao, B., Cheng, J., Wang, X., Song, L., Zhong, Z., Lin, Q. and Huang, H. (2005) Biotechnol. Lett. 27, 1821-1827
6. Song, L. P., Cheng, J. L., Wang, X. B., Zhang, Z., Fang, M., Zhou, Z. Y. and Huang, H. L. (2003) Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35, 503-510
7. Wang, X. B., Zhao, B. F., Zhao, Q., Piao, J. H., Liu, J., Lin, Q. and Huang, H. L. (2004) J. Biochem. (Tokyo) 135, 555-565
8. Fernandez, E. J. and Lolis, E. (2002) Annu. Rev. Pharmacol. Toxicol. 42, 469-499
9. Zlotnik, A. and Yoshie, Q. (2000) Immunity 12, 121-127
10. Nagira, M., Imai, T., Hieshima, K., Kusuda, J., Ridanpaa, M., Takagi, S., Nishimura, M., Kakizaki, M., Nomiyama, H. and Yoshie, O. (1997) J. Biol. Chem. 272, 19518-19524
11. Gunn, M. D., Tangemann, K., Tam, C., Cyster, J. G., Rosen, S. D. and Williams, L. T. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 258-263
12. Nagira, M., Imai, T., Yoshida, R., Takagi, S., Iwasaki, M., Baba, M., Tabira, Y., Akagi, J., Nomiyama, H. and Yoshie, O. (1998) Eur. J. Immunol. 28, 1516-1523
13. Saeki, H., Moore, A. M., Brown, M. J. and Hwang, S. T. (1999) J. Immunol. 162, 2472-2475
14. Cyster, J. G. (1999) J. Exp. Med. 189, 447-450
15. Chun, L., Yin, C. C., Song, J. Z., Liu, M. X., Piao, J. H., Lin, Q., Wang, X. B. and Huang, H. L. (2004) J. Biochem. (Tokyo) 136, 769-776
16. Clore, G. M., Appella, E., Yamada, M., Matsushima, K. and Gronenbom, A. M. (1990) Biochemistry 29, 1689-1696
17. Baldwin, E. T. Weber, I. T., St Charles, R., Xuan, J. C., Appella, E., Yamada, M., Matsushima, K., Edwards, B. F., Clore, G. M., Gronenborn, A. M. et al. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 502-506
18. Clark-Lewis, I., Schumacher, C., Baggiolini, M. and Moser, B. (1991) J. Biol. Chem. 266, 23128-23134
19. Elisseeva, E. L., Slupsty C. M., Crump, M. P., Clark-Lewis, I. and Sykes, B. D. (2000) J. Biol. Chem. 275, 26799-26805
20. Loetscher P., Gong, J. H., Dewald, B., Baggiolini, M. and Clark-Lewis, I. (1998) J. Biol. Chem. 273, 22279-22283
21. Crump, M. P., Gong, J. H., Loetscher, P., Rajarathnam, K., Amara, A., Arenzana-Seisdedos, F., Virelizier, J. L., Baggiolini, M., Sykes, B. D. and Clark-Lewis, I. (1997) EMBO J. 16, 6996-7007
22. Bruhl, H., Cihak, J., Stangassinger, M., Schlondorff, D. and Mack, M. (2001) J. Immunol. 166, 2420-2426
23. Kim, S. J., Suh, D., Park, S. E., Park, J. S., Byun, H. M., Lee, C., Lee, S. Y., Kim, I. and Oh, Y. K. (2003) Virology 314, 84-91
24. Nakahara, K. and Sakata, T. (2003) J. Gene Med. 5, 463-471
25. Guo, J. Q., Chen, L., Ai, H. W., Jing, J. N., Zhou, J. Y., Zhang, C. Y. and You, S. Y. (2004) Biochem. Biophys. Res. Commun. 320, 506-513
26. Challita-Eid, P. M., Abboud, C. N., Morrison, S. L., Penichet, M. L., Rosell, K. E., Poles, T., Hilchey, S. P., Planelles, V. and Rosenblatt, J. D. (1998) J. Immunol. 161, 3729-3736
27. Holzer, W., Petersen, F., Strittmatter, W., Matzku, S. and von Hoegen, I. (1996) Cytokine 8, 214-221
28. Mabondzo, A., Boussin, F.. Raoul, H., Le Naour, R., Gras, G., Vaslin, B., Bartholeyns, J., Romet-Lemonne, J. L. and Dormont, D. (1994) J. Gen. Virol. 75, 1451-1456
29. Arndt M. A., Krauss, J., Kipriyanov, S. M., Pfreundschuh, M. and Little, M. (1999) Blood 94, 2562-2568
30. Silla, L. M., Chen, J., Zhong, R. K., Whiteside, T. L. and Ball, E. D. (1995) Br J. Haematol. 89, 712-718
31. Davol, P. A., Smith, J. A., Kouttab, N., Elfenbein, G. J. and Lum, L. G. (2004) Clin. Prostate Cancer 3, 112-121
32. Loffler, A., Gruen, M., Wuchter C., Schriever, F., Kufer, P., Dreier, T., Hanakam, F., Baeuerle, P. A., Bommert, K., Karawajew, L. et al. (2003) Leukemia 17, 900-909
33. Fang, M., Zhao, R., Yang, Z., Zhang, Z., Li, H., Zhang, X. T., Lin, Q. and Huang, H. L. (2004) Gynecol. Oncol. 92, 135-146
34. Fang, M., Fang Z. R., Li, H., Jiang, X., Yin, C., Lin, Q. and Huang, H. (2002) High Technol. Lett. 12, 47-50
35. Fang, M., Yang, Z. Yu, X, C., Yin, C. C., Li, H., Zhao, R., Zhang, Z., Lin, Q. and Huang, H. L. (2003) Chin. Sci. Bull. 48, 1912-1918
36. Clark, W. R. (Ed.) (1991) in Experimental Foundations of Modern Immunology, 4th edn, pp. 331-333, Wiley, New York
37. Zhang, Z., Li, Z. H., Wang, F., Fang, M., Yin, C. C., Zhou, Z. Y., Lin, Q. and Huang, H. L. (2002) Protein Expression Purif. 26, 218-228
38. Ausubel, F. M. (1999) in Short Protocols in Molecular Biology: a Compendium of Methods from Current Protocols in Molecular Biology, 4th edn, pp. 332-333. Wiley, New York
39. Schumacher, U., Adam, E., Horny, H. P. and Dietl, J. (1996) Int. J. Exp. Pathol. 77, 219-227
40. Heo, D. S., Park, J. G., Hata, K., Day, R., Herberman, R. B. and Whiteside, T. L. (1990) Cancer Res. 50, 3681-3690
41. van Ojik, H. H. and Valerius, T. (2001) Crit. Rev. Oncol. Hematol. 38, 47-61
42. Cao, Y. and Lam, L. (2003) Adv. Drug Deliv. Rev. 55, 171-197
43. Simmons, G., Clapham, P. R., Picard, L., Offord, R. E., Rosenkilde, M. M., Schwartz, T. W., Buser, R., Wells, T. N. and Proudfoot, A. E. (1997) Science 276, 276-279
44. Proudfoot A. E., Power, C. A., Hoogewerf, A. J., Montjovent, M. O., Borlat, F., Offord, R. E. and Wells, T. N. (1996) J. Biol. Chem. 271, 2599-2603
45. Mosier, D. E., Picchio, G. R., Gulizia, R. J., Sabbe, R., Poignard, P., Picard, L., Offord, R. E., Thompson, D. A. and Wilken, J. (1999) J. Virol. 73, 3544-3550