The role of stereoselectivity of chemosensitizers in the reversal of multidrug resistance of mouse lymphoma cells

Anticancer Research

Volumn 18, Issue 4 C, 1998, Pages 3039-3044

  Szabó, Diana ^a   Molnar, Joseph ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Blood brain barrier; Butaclamol; Clopenthixol; Methotrimeprazine; Multidrug resistance; Stereoselectivity

Indexed keywords

BUTACLAMOL; CLOPENTHIXOL; GLYCOPROTEIN P; LEVOMEPROMAZINE;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG EFFECT; ENANTIOMER; LYMPHOMA CELL; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY; STEREOISOMERISM;

ANIMALS; ANTIPSYCHOTIC AGENTS; BUTACLAMOL; CLOPENTHIXOL; DRUG RESISTANCE, MULTIPLE; LYMPHOMA, T-CELL; METHOTRIMEPRAZINE; MICE; P-GLYCOPROTEIN; PROMETHAZINE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; VERAPAMIL;

EID: 0031813503     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Hofsli E and Nissen-Mayer J: Reversal of multidrug resistance by lipophillic drugs. Cancer Res 50: 3997-4002, 1990.
2. Fisher GA, Brophy NA, Yahanda AM, Adler KA, Lum BL, Bartlett NL, Halsay J and Sikic BI: The modulation multidrug resistance: clinical studies at Stanford. In: The Mechanism and New Approach on Drug Resistance of Cancer Cells ed. T. Miyazaki, F. Takaku and K. Sakurada. p.255-266, 1993. Elsevier Science Publishers B.V.
3. Aszalos A: Modulation of multidrug resistance in cancer by immunosuppressive agents. Pathology Oncology Research 1: 64-70, 1995.
4. Molnár J, Szabó D, Csuri K and Motohashi N: Cytotoxicity and calculation of half-mustard type phenothiazines. Anticancer Research (1998) in preparation.
5. Molnár J, Gálfi M, Lózsa A and Nakamura MJ: Inhibition of bacterial plasmid replication by stereoselective binding by tricyclic psychopharmacons. Research Comm. in Chem. Pathol. and Pharmacology 43/2: 235-249, 1984.
6. Cornwell MM, Pastan I, Gottesmann MM: Certain Calcium channel blockers bind specifically to multidrug resistant KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein. J. Biological Chemistry 262: 2166-2170, 1987.
7. Wainer IW, Granvil CP: Stereoselective separations of chiral anticancer drugs and their application to pharmacodynamic and pharmacokinetic studies. Ther Drug Monit Dec, 15 (6): 570-5, 1993.
8. Wainer IW: Stereoisomers in clinical oncology: Why it is important to know what the right and left hands are doing. Ann. Oncol 4 Suppl 2: 7-13, 1993.
9. Hiroshi Isobe, Awtar Krishan, Larry Wellham, Yoshisaku Kawakami: Drug resitance and p-glycoprotein expression, DNA topoisomerase II activity and glutatione content in malignant mesothelioma cell lines establised after in vivo chemotherapy. In: The Mechanism and New Approach on Drug Resistance of cancer cells . T. Miyazaki, F. Takaka and K. Sakurada, Elsevier Science Publishers p. 103-114, 1993.
10. Gruber A, Peterson C, Reizenstein P: D-verapamil and L-verapamil are equally effective in increasing vincristine accumulation in leukemic cells in vitro. International Journal of Cancer 41: 224-226, 1988.
11. Hoolt V, Kouba M, Dietel M, Vogt G: Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein. Biochem. Pharmacol. Jun 23; 43 (12): 2601-8 , 1992.
12. Bormann LS, Bornmann WG, Kuehne ME: Modulation of drug cytotoxicity by stereoisomeric series of C-20 vinblastine congmers that lack antimicrotubule activity. Cancer-Chemother-Pharmacol 31/5: 343-9, 1993.
13. Klimecki WT, Taylor CW, Dalton WS: Inhibition of cell-mediated cytolysis and P-glycoprotein function in natural killer cells by verapamil isomers and cyclosporine A analogs. J Clin Immunol May 15(3): 152-8, 1993.
14. 3H-cis-Z-flupenthixol binding and on adenylate cyclase activity in vitro. Life Sciences 23: 551-556, 1978.
15. Robert TA, Hagardorn AW and Daigneault EA: Differential stereoselectivity of metotrimiprasine enantiomers for selected central nervous system receptor types. Molec Pharmacol 21: 315-319, 1982.
16. Cumdell RB and Gilbert A: Cis-trans isomerism, In: Nelson T. ed., Photochemistry Studies in Modern Chemistry. Academic Press, New York, N.Y. P. 168, 1970.
17. Motohashi N, Kurihara T, Kawase M, Hever A, Tanaka M, Szabo D, Nacsa J, Yamanaka W, Kerim A, Molnar J: Drug resistance reversal, antimutagenicity and antiretroviral effect of phthalimido-and chlorethyl-phenothiazines. Anticancer Res (in press).
18. Bean WT, Thomas GE, Mamone JY, Homan SM, Levy BK, Johanson FE, Coscia CJ: Overexpression of sigma receptors in nonneural human tumors. Cancer Res 51: 6558-62, 1991.
19. Vilner BJ, de Costa BR, Bowen WD: Cytotoxic effects of sigma ligands: sigma receptor-mediated alterations in cellular morphology and viability. J-of Neuroscience 15/1: 117-134, 1995.
20. Hellewell SB, Bowen WD: A sigma-like binding site rat pheochromocytoma PC12 cells. Brain Res 527: 244-253, 1990.
21. Largent BL, Wilestrom H, Gandlach AL, Snader SH: Structural determinants of sigma receptor affinity. J Mol Pharmacol 32: 772-784.
22. Plassat JL, Amlaiky N and Hen R: Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase. Molecular Pharmacology 44: 229-236, 1993.
23. 125I-L-750. 667, Molecular Pharmacology 50: 1658-1664, 1996.
24. Molnár J, Szabó D, Mándi Y, I Mucsi, Fischer J, Varga A, S König, Motohashi N: Multidrug resistance reversal in mouse lymphoma cells by heterocyclic compounds. Anticancer Res 18: 3033-3038, 1998.
25. Hevér A, Santelli-Rouvier C, Brouant P, Khyari S, Molnár J, Barra Y, Barbe J: Effect of new thioacridine derivatives on p-gp function and on mdrl gene expression. Anticancer Res 18: 3053-3058, 1998.
26. Schwartz JB, Capili H, Wainer IW: Verapamil stereoisomers during racemic verapamil administration: effects of aging and comparisons to administration of individual stereoisomers. Clin. Pharmacol. Ther. Oct: 56(4): 368-76, 1994.
27. Molnár J, Gálfi M, Lózsa A, Nakamaru MJ: Inhibition of bacterial plasmid replication by stereoselective binding by tricyclic psychopharmacons. Research Communications in Chemical Pathology and Pharmacology 43: 235-249, 1984.