Medical complications after lung transplantation

Seminars in Respiratory and Critical Care Medicine

Volumn 27, Issue 5, 2006, Pages 508-520

  Arcasoy, Selim M ^a,b   Wilt, Jessie ^a,b  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

Complications; Immunosuppression; Lung transplantation; Posttransplant malignancy; Venous thromboembolism

Indexed keywords

CARDIOVASCULAR DISEASE; CHRONIC GRAFT REJECTION; GASTROINTESTINAL DISEASE; GRAFT INFECTION; HEMATOLOGIC DISEASE; HYPOGAMMAGLOBULINEMIA; IMMUNOSUPPRESSIVE TREATMENT; LUNG CARCINOMA; LUNG COMPLICATION; LUNG TRANSPLANTATION; LYMPHOPROLIFERATIVE DISEASE; PLEURA DISEASE; POSTTRANSPLANTATION LYMPHOPROLIFERATIVE DISORDER; PRIORITY JOURNAL; REVIEW; VENOUS THROMBOEMBOLISM;

HUMANS; LUNG TRANSPLANTATION; POSTOPERATIVE COMPLICATIONS;

EID: 33750550453     PISSN: 10693424     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-954611     Document Type: Review

References (119)

1. Reitz BA, Wallwork JL, Hunt SA, et al. Heart-lung transplantation: successful therapy for patients with pulmonary vascular disease. N Engl J Med 1982;306:557-564
2. Trulock EP, Edwards LB, Taylor DO, Boucek MM, Keck BM, Hertz MI. Registry of the International Society for Heart and Lung Transplantation: twenty-second official adult lung and heart-lung transplant report - 2005. J Heart Lung Transplant 2005;24:956-967
3. Arcasoy SM. Medical complications and management of lung transplant recipients. Respir Care Clin N Am 2004;10: 505-529
4. Konen E, Weisbrod GL, Pakhale S, Chung T, Paul NS, Hutcheon MA. Fibrosis of the upper lobes: a newly identified late-onset complication after lung transplantation? AJR Am J Roentgenol 2003;181:1539-1543
5. Pakhale SS, Hadjiliadis D, Howell DN, et al. Upper lobe fibrosis: a novel manifestation of chronic allograft dysfunction in lung transplantation. J Heart Lung Transplant 2005; 24:1260-1268
6. Collins J, Hartman MJ, Warner TF, et al. Frequency and CT findings of recurrent disease after lung transplantation. Radiology 2001;219:503-509
7. Kazerooni EA, Cascade PN. Recurrent miliary sarcoidosis after lung transplantation. Radiology 1995;194:913
8. Kazerooni EA, Jackson C, Cascade PN. Sarcoidosis: recurrence of primary disease in transplanted lungs. Radiology 1994;192:461-464
9. Yeatman M, McNeil K, Smith JA, et al. Lung transplantation in patients with systemic diseases: an eleven-year experience at Papworth Hospital. J Heart Lung Transplant 1996;15:144-149
10. Johnson BA, Duncan SR, Ohori NP, et al. Recurrence of sarcoidosis in pulmonary allograft recipients. Am Rev Respir Dis 1993;148:1373-1377
11. Bjortuft O, Foerster A, Boe J, Geiran O. Single-lung transplantation as treatment for end-stage pulmonary sarcoidosis: recurrence of sarcoidosis in two different lung allografts in one patient. J Heart Lung Transplant 1994; 13:24-29
12. Carre P, Rouquette I, Durand D, et al. Recurrence of sarcoidosis in a human lung allograft. Transplant Proc 1995; 27:1686
13. Martinez FJ, Orens JB, Deeb M, Brunsting LA, Flint A, Lynch JP III. Recurrence of sarcoidosis following bilateral allogeneic lung transplantation. Chest 1994;106:1597-1599
14. Muller C, Briegel J, Hauer M, et al. Sarcoidosis recurrence following lung transplantation. Transplantation 1996;61: 1117-1119
15. Etienne B, Bertocchi M, Gamondes JP, et al. Relapsing pulmonary Langerhans' cell histiocytosis after lung transplantation. Am J Respir Crit Care Med 1998;157:288-291
16. Gabbay E, Dark JH, Ashcroft T, et al. Recurrence of Langerhans' cell granulomatosis following lung transplantation. Thorax 1998;53:326-327
17. Habib SB, Congleton J, Carr D, et al. Recurrence of recipient Langerhans' cell histiocytosis following bilateral lung transplantation. Thorax 1998;53:323-325
18. Dauriat G, Mal H, Thabut G, et al. Lung transplantation for pulmonary Langerhans' cell histiocytosis: a multicenter analysis. Transplantation 2006;81:746-750
19. O'Brien JD, Lium JH, Parosa JF, Deyoung BR, Wick MR, Trulock EP. Lymphangiomyomatosis recurrence in the allograft after single-lung transplantation. Am J Respir Crit Care Med 1995;151:2033-2036
20. Bittmann I, Dose TB, Muller C, Dienemann H, Vogelmeier C, Lohrs U. Lymphangioleiomyomatosis: recurrence after single lung transplantation. Hum Pathol 1997;28:1420-1423
21. Boehler A, Speich R, Russi EW, Weder W. Lung transplantation for lymphangioleiomyomatosis. N Engl J Med 1996;335:1275-1280
22. Nine JS, Yousem SA, Paradis IL, Keenan R, Griffith BP. Lymphangioleiomyomatosis: recurrence after lung transplantation. J Heart Lung Transplant 1994;13:714-719
23. Garver RI Jr, Zorn GL, Wu X, McGiffin DC, Young KR Jr, Pinkard NB. Recurrence of bronchioloalveolar carcinoma in transplanted lungs. N Engl J Med 1999;340:1071-1074
24. de Perrot M, Chernenko S, Waddell TK, et al. Role of lung transplantation in the treatment of bronchogenic carcinomas for patients with end-stage pulmonary disease. J Clin Oncol 2004;22:4351-4356
25. Baz MA, Kussin PS, Van Trigt P, Davis RD, Roggli VL, Tapson VF. Recurrence of diffuse panbronchiolitis after lung transplantation. Am J Respir Crit Care Med 1995; 151:895-898
26. King MB, Jessurun J, Hertz MI. Recurrence of desquamative interstitial pneumonia after lung transplantation. Am J Respir Crit Care Med 1997;156:2003-2005
27. Frost AE, Keller CA, Brown RW, et al. Giant cell interstitial pneumonitis: disease recurrence in the transplanted lung. Am Rev Respir Dis 1993;148:1401-1404
28. Calabrese F, Giacometti C, Rea F, et al. Recurrence of idiopathic pulmonary hemosiderosis in a young adult patient after bilateral single-lung transplantation. Transplantation 2002;74:1643-1645
29. Cook RC, Fradet G, English JC, et al. Recurrence of intravenous talc granulomatosis following single lung transplantation. Can Respir J 1998;5:511-514
30. Parker LA, Novotny DB. Recurrent alveolar proteinosis following double lung transplantation. Chest 1997;111: 1457-1458
31. Stewart S, McNeil K, Nashef SA, Wells FC, Higenbottam TW, Wallwork J. Audit of referral and explant diagnoses in lung transplantation: a pathologic study of lungs removed for parenchymal disease. J Heart Lung Transplant 1995;14: 1173-1186
32. Mal H, Guignabert C, Thabut G, et al. Recurrence of pulmonary emphysema in an alpha-1 proteinase inhibitor-deficient lung transplant recipient. Am J Respir Crit Care Med 2004;170:811-814
33. Buell JF, Gross TG, Woodle ES. Malignancy after transplantation. Transplantation 2005;80:S254-S264
34. Maurer JM, Frost AE, Glanville AR, Estenne M, Higenbottam T. International Guidelines for the Selection of Lung Transplant Candidates. Am J Respir Crit Care Med 1998; 158:335-339
35. Levine SM. A survey of clinical practice of lung transplantation in North America. Chest 2004;125:1224-1238
36. Cohen JI. Epstein-Barr virus infection. N Engl J Med 2000; 343:481-492
37. Bakker NA, van Imhoff GW, Verschuuren EA, et al. Early onset post-transplant lymphoproliferative disease is associated with allograft localization. Clin Transplant 2005;19: 327-334
38. Ramalingam P, Rybicki L, Smith MD, et al. Posttransplant lymphoproliferative disorders in lung transplant patients: the Cleveland Clinic experience. Mod Pathol 2002;15:647-656
39. Reams BD, McAdams HP, Howell DN, Steele MP, Davis RD, Palmer SM. Posttransplant lymphoproliferative disorder: incidence, presentation, and response to treatment in lung transplant recipients. Chest 2003;124:1242-1249
40. Gao SZ, Chaparro SV, Perlroth M, et al. Post-transplantation lymphoproliferative disease in heart and heart-lung transplant recipients: 30-year experience at Stanford University. J Heart Lung Transplant 2003;22:505-514
41. Benden C, Aurora P, Burch M, et al. Monitoring of Epstein-Barr viral load in pediatric heart and lung transplant recipients by real-time polymerase chain reaction. J Heart Lung Transplant 2005;24:2103-2108
42. Leung E, Shenton BK, Green K, et al. Dynamic EBV gene loads in renal, hepatic, and cardiothoracic transplant recipients as determined by real-time PCR light cycler. Transpl Infect Dis 2004;6:156-164
43. Marom EM, McAdams HP, Butnor KJ, Coleman RE. Positron emission tomography with fluoro-2-deoxy-D-glucose (FDG-PET) in the staging of post transplant lymphoproliferative disorder in lung transplant recipients. J Thorac Imaging 2004;19:74-78
44. Wigle DA, Chaparro C, Humar A, Hutcheon MA, Chan CK, Keshayjee S. Epstein-Barr virus serology and posttransplant lymphoproliferative disease in lung transplantation. Transplantation 2001;72:1783-1786
45. Paranjothi S, Yusen RD, Kraus MD, Lynch JP, Patterson GA, Trulock EP. Lymphoproliferative disease after lung transplantation: comparison of presentation and outcome of early and late cases. J Heart Lung Transplant 2001;20:1054-1063
46. Hachem RR, Chakinala MM, Yusen RD, et al. Abdominal-pelvic lymphoproliferative disease after lung transplantation: presentation and outcome. Transplantation 2004;77:431-437
47. Tsai DE, Hardy CL, Tomaszewski JE, et al. Reduction in immunosuppression as initial therapy for posttransplant lymphoproliferative disorder: analysis of prognostic variables and long-term follow-up of 42 adult patients. Transplantation 2001;71:1076-1088
48. Malouf MA, Chhajed PN, Hopkins P, Plit M, Turner J, Glanville AR. Anti-viral prophylaxis reduces the incidence of lymphoproliferative disease in lung transplant recipients. J Heart Lung Transplant 2002;21:547-554
49. Knoop C, Kentos A, Remmelink M, et al. Post-transplant lymphoproliferative disorders after lung transplantation: first-line treatment with rituximab may induce complete remission. Clin Transplant 2006;20:179-187
50. Oertel SH, Verschuuren E, Reinke P, et al. Effect of anti-CD 20 antibody rituximab in patients with post-transplant lymphoproliferative disorder (PTLD). Am J Transplant 2005;5:2901-2906
51. Hubbard R, Venn A, Lewis S, Britton J. Lung cancer and cryptogenic fibrosing alveolitis. a population-based cohort study. Am J Respir Crit Care Med 2000;161:5-8
52. Arcasoy SM, Hersh C, Christie JD, et al. Bronchogenic carcinoma complicating lung transplantation. J Heart Lung Transplant 2001;20:1044-1053
53. Collins J, Kazerooni EA, Lacomis J, et al. Bronchogenic carcinoma after lung transplantation: frequency, clinical characteristics, and imaging findings. Radiology 2002;224: 131-138
54. Abrahams NA, Meziane M, Ramalingam P, Mehta A, DeCamp M, Farver CF. Incidence of primary neoplasms in explanted lungs: long-term follow-up from 214 lung transplant patients. Transplant Proc 2004;36:2808-2811
55. Lee P, Minai OA, Mehta AC, DeCamp MM, Murthy S. Pulmonary nodules in lung transplant recipients: etiology and outcome. Chest 2004;125:165-172
56. Ferrer J, Roldan J, Roman A, et al. Acute and chronic pleural complications in lung transplantation. J Heart Lung Transplant 2003;22:1217-1225
57. Herridge MS, de Hoyos AL, Chaparro C, Winton TL, Kesten S, Maurer JR. Pleural complications in lung transplant recipients. J Thorac Cardiovasc Surg 1995;110: 22-26
58. Judson MA, Handy JR, Sahn SA. Pleural effusions following lung transplantation: time course, characteristics, and clinical implications. Chest 1996;109:1190-1194
59. Judson MA, Handy JR, Sahn SA. Pleural effusion from acute lung rejection. Chest 1997;111:1128-1130
60. Kroshus TJ, Kshettry VR, Hertz MI, Bolman RM III. Deep venous thrombosis and pulmonary embolism after lung transplantation. J Thorac Cardiovasc Surg 1995;110:540-544
61. Nathan SD, Barnett SD, Urban BA, Nowalk C, Moran BR, Burton N. Pulmonary embolism in idiopathic pulmonary fibrosis transplant recipients. Chest 2003;123:1758-1763
62. Jankowich MD. Idiopathic pulmonary fibrosis in transplantation. Chest 2003;124:2404 author reply 2404-2405
63. Burns KE, Iacono AT. Incidence of clinically unsuspected pulmonary embolism in mechanically ventilated lung transplant recipients. Transplantation 2003;76:964-968
64. Burns KE, Iacono AT. Pulmonary embolism on postmortem examination: an under-recognized complication in lung-transplant recipients? Transplantation 2004;77:692-698
65. Yegen HA, Lederer DJ, Wilt JS, et al. Risk factors for venous thromboembolism in lung transplant recipient [abstract]. Am J Respir Crit Care Med 2006;3:A536
66. Hammoud D, Chin B. False-positive ventilation-perfusion scan in a patient with a transplanted lung. Clin Nucl Med 2003;28:472-475
67. King-Biggs MB, Dunitz JM, Park SJ, Kay Savik S, Hertz MI. Airway anastomotic dehiscence associated with use of sirolimus immediately after lung transplantation. Transplantation 2003;75:1437-1443
68. Groetzner J, Kur F, Spelsberg F, et al. Airway anastomosis complications in de novo lung transplantation with sirolimus-based immunosuppression. J Heart Lung Transplant 2004;23:632-638
69. Vlahakis NE, Rickman OB, Morgenthaler T. Sirolimus-associated diffuse alveolar hemorrhage. Mayo Clin Proc 2004;79:541-545
70. Morelon E, Stern M, Israel-Biet D, et al. Characteristics of sirolimus-associated interstitial pneumonias in renal transplant patients. Transplantation 2001;72:787-790
71. Morelon E, Stern M, Kreis H. Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipients. N Engl J Med 2000;343:22S-226
72. McWilliams TJ, Levvey BJ, Russell PA, Milne DG, Snell GI. Interstitial pneumonitis associated with sirolimus: a dilemma for lung transplantation. J Heart Lung Transplant 2003;22:210-213
73. Champion L, Stern M, Israel-Biet D, et al. Brief communication: sirolimus-associated pneumonitis: 24 cases in renal transplant recipients. Ann Intern Med 2006;144: 505-509
74. Lindenfeld JA, Simon SF, Zamora MR, et al. BOOP is common in cardiac transplant recipients switched from a calcineurin inhibitor to sirolimus. Am J Transplant 2005;5:1392-1396
75. Garrean S, Massad MG, Tshibaka M, Hanhan Z, Caines AE, Benedetti E. Sirolimus-associated interstitial pneumonitis in solid organ transplant recipients. Clin Transplant 2005;19:698-703
76. Manito N, Kaplinsky EJ, Bernat R, et al. Fatal interstitial pneumonitis associated with sirolimus therapy in a heart transplant recipient. J Heart Lung Transplant 2004;23:780-782
77. Mal H, Brugiere O, Sleiman C, et al. Morbidity and mortality related to the native lung in single lung transplantation for emphysema. J Heart Lung Transplant 2000; 19:220-223
78. McAdams HP, Erasmus JJ, Palmer SM. Complications (excluding hyperinflation) involving the native lung after single-lung transplantation: incidence, radiologic features, and clinical importance. Radiology 2001;218:233-241
79. Speziali G, McDougall JC, Midthun DE, et al. Native lung complications after single lung transplantation for emphysema. Transpl Int 1997;10:113-115
80. Venuta F, Boehler A, Rendina EA, et al. Complications in the native lung after single lung transplantation. Eur J Cardiothorac Surg 1999;16:54-58
81. Frost AE, Keller CA, Noon GP, Short HD, Cagle PT. Outcome of the native lung after single lung transplant. Multiorgan Transplant Group. Chest 1995;107:981-984
82. Yonan NA, el-Gamel A, Egan J, Kakadellis J, Rahman A, Deiraniya AK. Single lung transplantation for emphysema: predictors for native lung hyperinflation. J Heart Lung Transplant 1998;17:192-201
83. Weill D, Torres F, Hodges TN, Olmos JJ, Zamora MR. Acute native lung hyperinflation is not associated with poor outcomes after single lung transplant for emphysema. J Heart Lung Transplant 1999;18;1080-1087
84. Moy ML, Loring SH, Ingenito EP, Mentzer SJ, Reilly JJ Jr. Causes of allograft dysfunction after single lung transplantation for emphysema: extrinsic restriction versus intrinsic obstruction. Brigham and Women's Hospital Lung Transplantation Group. J Heart Lung Transplant 1999;18: 986-993
85. Anderson MB, Kriett JM, Kapelanski DP, Perricone A, Smith CM, Jamieson SW. Volume reduction surgery in the native lung after single lung transplantation for emphysema. J Heart Lung Transplant 1997;16:752-757
86. Schulman LL, O'Hair DP, Cantu E, McGregor C, Ginsberg ME. Salvage by volume reduction of chronic allograft rejection in emphysema. J Heart Lung Transplant 1999;18:107-112
87. Venuta F, De Giacomo T, Rendina EA, et al. Thoracoscopic volume reduction of the native lung after single lung transplantation for emphysema. Am J Respir Crit Care Med 1998;157:292-293
88. Kotloff RM, Ahya VN. Medical complications of lung transplantation. Eur Respir J 2004;23:334-342
89. Verleden GM, Besse T, Maes B. Successful conversion from cyclosporine to tacrolimus for gastric motor dysfunction in a lung transplant recipient. Transplantation 2002;73:1974-1976
90. Weinkauf JG, Yiannopoulos A, Faul JL. Transcutaneous electrical nerve stimulation for severe gastroparesis after lung transplantation. J Heart Lung Transplant 2005;24:1444.e1-1444.e3
91. Yiannopoulos A, Shafazand S, Ziedalski T, et al. Gastric pacing for severe gastroparesis in a heart-lung transplant recipient. J Heart Lung Transplant 2004;23:371-374
92. Young LR, Hadjiliadis D, Davis RD, Palmer SM. Lung transplantation exacerbates gastroesophageal reflux disease. Chest 2003;124:1689-1693
93. D'Ovidio F, Singer LG, Hadjiliadis D, et al. Prevalence of gastroesophageal reflux in end-stage lung disease candidates for lung transplant. Ann Thorac Surg 2005;80:1254-1260
94. D'Ovidio F, Mura M, Tsang M, et al. Bile acid aspiration and the development of bronchiolitis obliterans after lung transplantation. J Thorac Cardiovasc Surg 2005;129:1144-1152
95. Hadjiliadis D, Duane Davis R, Steele MP, et al. Gastroesophageal reflux disease in lung transplant recipients. Clin Transplant 2003;17:363-368
96. Palmer SM, Miralles AP, Howell DN, Brazer SR, Tapson VF, Davis RD. Gastroesophageal reflux as a reversible cause of allograft dysfunction after lung transplantation. Chest 2000;118:1214-1217
97. Davis RD Jr, Lau CL, Eubanks S, et al. Improved lung allograft function after fundoplication in patients with gastroesophageal reflux disease undergoing lung transplantation. J Thorac Cardiovasc Surg 2003;125:533-542
98. Smith PC, Slaughter MS, Petty MG, Shumway SJ, Kshettry VR, Bolman RM III. Abdominal complications after lung transplantation. J Heart Lung Transplant 1995; 14:44-51
99. Gilljam M, Chaparro C, Tullis E, Chan C, Keshavjee S, Hutcheon M. GI complications after lung transplantation in patients with cystic fibrosis. Chest 2003;123:37-41
100. Hoekstra HJ, Hawkins K, de Boer WJ, Rottier K, van der Bij W. Gastrointestinal complications in lung transplant survivors that require surgical intervention. Br J Surg 2001; 88:433-438
101. Lubetkin EI, Lipson DA, Palevsky HI, et al. GI complications after orthotopic lung transplantation. Am J Gastroenterol 1996;91:2382-2390
102. Dellon ES, Morgan DR, Mohanty SP, Davis K, Aris RM. High incidence of gastric bezoars in cystic fibrosis patients after lung transplantation. Transplantation 2006;81:1141-1146
103. Hachem RR, Chakinala MM, Yusen RD, et al. Abdominal-pelvic lymphoproliferative disease after lung transplantation: presentation and outcome. Transplantation 2004;77:431-437
104. Calvet A, Pujol MO, Bertocchi M, Bastien O, Boissonnat P, Mornex JF. Parvovirus B19 infection in thoracic organ transplant recipients. J Clin Virol 1999;13:37-42
105. Kariyawasam HH, Gyi KM, Hodson ME, Cohen BJ. Anaemia in lung transplant patient caused by parvovirus B19. Thorax 2000;55:619-620
106. Salerno CT, Burdine J, Perry EH, Kshettry VR, Hertz MI, Bolman RM III. Donor-derived antibodies and hemolysis after ABO-compatible but nonidentical heart-lung and lung transplantation. Transplantation 1998;65: 261-264
107. Taaning E, Morling N, Mortensen SA, Pettersson G, Simonsen AC. Severe hemolysis caused by graft-derived anti-B production after lung transplantation. J Heart Lung Transplant 1996;15:850-851
108. Qu L, Kiss JE. Thrombotic microangiopathy in transplantation and malignancy. Semin Thromb Hemost 2005; 31:691-699
109. Hachem RR, Yusen RD, Chakinala MM, Aloush AA, Patterson GA, Trulock EP. Thrombotic microangiopathy after lung transplantation. Transplantation 2006;81:57-63
110. Goldfarb NS, Avery RK, Goormastic M, et al. Hypogammaglobulinemia in lung transplant recipients. Transplantation 2001;71:242-246
111. Kawut SM, Shah L, Wilt JS, et al. Risk factors and outcomes of hypogammaglobulinemia after lung transplantation. Transplantation 2005;79:1723-1726
112. Yip NH, Lederer DJ, Kawut SM, et al. Immunoglobulin G levels before and after lung transplantation. Am J Respir Crit Care Med 2006;173:917-921
113. Rocha PN, Rocha AT, Palmer SM, Davis RD, Smith SR. Acute renal failure after lung transplantation: incidence, predictors and impact on perioperative morbidity and mortality. Am J Transplant 2005;5:1469-1476
114. Ishani A, Erturk S, Hertz MI, Matas AJ, Savik K, Rosenberg ME. Predictors of renal function following lung or heart-lung transplantation. Kidney Int 2002;61:2228-2234
115. Venuta F, De Giacomo T, Rendina EA, et al. Recovery of chronic renal impairment with sirolimus after lung transplantation. Ann Thorac Surg 2004;78:1940-1943
116. Shitrit D, Rahamimov R, Gidon S, et al. Use of sirolimus and low-dose calcineurin inhibitor in lung transplant recipients with renal impairment: results of a controlled pilot study. Kidney Int 2005;67:1471-1475
117. Chobanian AV, Bakris GL, Black HR, et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003;42:1206-1252
118. Fletcher B, Berra K, Ades P, et al. Managing abnormal blood lipids: a collaborative approach. Circulation 2005;112: 3184-3209
119. Johnson BA, Iacono AT, Zeevi A, McCurry KR, Duncan SR. Statin use is associated with improved function and survival of lung allografts. Am J Respir Crit Care Med 2003;167:1271-1278