Dcr2 targets Ire1 and downregulates the unfolded protein response in Saccharomyces cerevisiae

EMBO Reports

Volumn 7, Issue 11, 2006, Pages 1124-1127

  Guo, Jinbai ^a   Polymenis, Michael ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; DOSE DEPENDENT CELL CYCLE REGULATOR 2; PHOSPHATASE; PROTEIN IRE1; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FUNGAL CELL; GENE OVEREXPRESSION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

ANIMALS; DOWN-REGULATION; MEMBRANE GLYCOPROTEINS; MODELS, GENETIC; OPEN READING FRAMES; PEDIGREE; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROTEIN FOLDING; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; RNA SPLICING; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 33750534382     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7400813     Document Type: Article

References (22)

1. Brewer JW, Diehl JA (2000) PERK mediates cell-cycle exit during the mammalian unfolded protein response. Proc Natl Acad Sci USA 97: 12625-12630
2. Brewer JW, Hendershot LM, Sherr CJ, Diehl JA (1999) Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression. Proc Natl Acad Sci USA 96: 8505-8510
3. Gelperin DM et al (2005) Biochemical and genetic analysis of the yeast proteome with a movable ORF collection. Genes Dev 19: 2816-2826
4. Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS (2003) Global analysis of protein expression in yeast. Nature 425: 737-741
5. Han BK, Bogomolnaya LM, Totten JM, Blank HM, Dangott LJ, Polymenis M (2005) Bem1p, a scaffold signaling protein, mediates cyclin-dependent control of vacuolar homeostasis in Saccharomyces cerevisiae. Genes Dev 19: 2606-2618
6. Kaiser C, Michaelis S, Mitchell A (1994) Methods in Yeast Genetics. Cold Spring Harbor, NY, USA: Cold Spring Harbor Laboratory Press
7. Kaufman RJ, Scheuner D, Schroder M, Shen X, Lee K, Liu CY, Arnold SM (2002) The unfolded protein response in nutrient sensing and differentiation. Nat Rev Mol Cell Biol 3: 411-421
8. Kawahara T, Yanagi H, Yura T, Mori K (1997) Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response. Mol Biol Cell 8: 1845-1862
9. Leber JH, Bernales S, Walter P (2004) IRE1-independent gain control of the unfolded protein response. PLoS Biol 2: E235
10. Niwa M, Patil CK, DeRisi J, Walter P (2005) Genome-scale approaches for discovering novel nonconventional splicing substrates of the Ire1 nuclease. Genome Biol 6: R3
11. Papa FR, Zhang C, Shokat K, Walter P (2003) Bypassing a kinase activity with an ATP-competitive drug. Science 302: 1533-1537
12. Pathak R, Bogomolnaya LM, Guo J, Polymenis M (2004) Gid8p (Dcr1p) and Dcr2p function in a common pathway to promote START completion in Saccharomyces cerevisiae. Eukaryot Cell 3: 1627-1638
13. Patil C, Walter P (2001) Intracellular signaling from the endoplasmic reticulum to the nucleus: The unfolded protein response in yeast and mammals. Curr Opin Cell Biol 13: 349-355
14. Polymenis M, Schmidt EV (1997) Coupling of cell division to cell growth by translational control of the G1 cyclin CLN3 in yeast. Genes Dev 11: 2522-2531
15. Rutkowski DT, Kaufman RJ (2004) A trip to the ER: Coping with stress. Trends Cell Biol 14: 20-28
16. Schroder M, Chang JS, Kaufman RJ (2000) The unfolded protein response represses nitrogen-starvation induced developmental differentiation in yeast. Genes Dev 14: 2962-2975
17. Schroder M, Clark R, Kaufman RJ (2003) IRE1- and HAC1-independent transcriptional regulation in the unfolded protein response of yeast. Mol Microbiol 49: 591-606
18. Shamu CE, Walter P (1996) Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. EMBO J 15: 3028-3039
19. Sidrauski C, Cox JS, Walter P (1996) tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Cell 87: 405-413
20. Sidrauski C, Walter P (1997) The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 90: 1031-1039
21. Tong AH et al (2001) Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science 294: 2364-2368
22. Welihinda AA, Tirasophon W, Green SR, Kaufman RJ (1998) Protein serine/ threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase. Mol Cell Biol 18: 1967-1977