Endoscopic ultrasound fine needle aspirate DNA analysis to differentiate malignant and benign pancreatic masses

American Journal of Gastroenterology

Volumn 101, Issue 11, 2006, Pages 2493-2500

  Khalid, Asif ^a,c   Nodit, Laurentia ^a   Zahid, Maliha ^a   Bauer, Kathy ^a   Brody, Debra ^a   Finkelstein, Sydney D ^b   McGrath, Kevin M ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b Redpath Integrated Pathology Inc   (United States)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ALLELE; ARTICLE; ASPIRATION BIOPSY; AUTOIMMUNE PANCREATITIS; AUTOSOME; CAPILLARY ELECTROPHORESIS; CHRONIC PANCREATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOLOGY; DIAGNOSTIC ACCURACY; DIFFERENTIAL DIAGNOSIS; DISEASE SEVERITY; ENDOSCOPIC BIOPSY; FEMALE; HETEROZYGOSITY LOSS; HUMAN; MALE; MALIGNANT NEOPLASTIC DISEASE; MICROSATELLITE MARKER; MUTATION; PANCREAS CANCER; PANCREATITIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; ULTRASOUND;

ADULT; AGED; AGED, 80 AND OVER; AUTOIMMUNE DISEASES; BIOPSY, FINE-NEEDLE; DIAGNOSIS, DIFFERENTIAL; ENDOSONOGRAPHY; FEMALE; GENES, RAS; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; PANCREATIC DISEASES; PANCREATIC NEOPLASMS; PANCREATITIS; POINT MUTATION; POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDIES;

EID: 33750531051     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1111/j.1572-0241.2006.00740.x     Document Type: Article

References (41)

1. Abraham SC, Wilentz RE, Yeo CJ, et al. Pancreaticoduodenectomy (Whipple resections) in patients without malignancy: Are they all 'chronic pancreatitis'? Am J Surg Pathol 2003;27:110-20.
2. Weber SM, Cubukcu-Dimopulo O, Palesty JA, et al. Lymphoplasmacytic sclerosing pancreatitis: Inflammatory mimic of pancreatic carcinoma. J Gastrointest Surg 2003;7:129-37.
3. Farrell JJ, Garber J, Sahani D, et al. EUS findings in patients with autoimmune pancreatitis. Gastrointest Endosc 2004;60:927-36.
4. Suits J, Frazee R, Erickson RA. Endoscopic ultrasound and fine needle aspiration for the evaluation of pancreatic masses. Arch Surg 1999;134:639-42.
5. Chang KJ, Nguyen P, Erickson RA, et al. The clinical utility of endoscopic ultrasound-guided fine-needle aspiration in the diagnosis and staging of pancreatic carcinoma. Gastrointest Endosc 1997;45:387-93.
6. Wiersema MJ, Vilmann P, Giovannini M, et al. Endosonography-guided fine-needle aspiration biopsy: Diagnostic accuracy and complication assessment. Gastroenterology 1997;112:1087-95.
7. Hruban RH, Adsay NV, Albores-Saavedra J, et al. Pancreatic intraepithelial neoplasia: A new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol 2001;25:579-86.
8. Apple SK, Hecht JR, Lewin DN, et al. Immunohistochemical evaluation of K-ras, p53, and HER-2/neu expression in hyperplastic, dysplastic, and carcinomatous lesions of the pancreas: Evidence for multistep carcinogenesis. Hum Pathol 1999;30:123-9.
9. Griffin CA, Hruban RH, Morsberger LA, et al. Tumor suppressive pathways in pancreatic carcinoma. Cancer Res 1997;57:1731-4.
10. Mizumoto K, Tanaka M. Genetic diagnosis of pancreatic cancer. J Hepatobiliary Pancreat Surg 2002;9:39-44.
11. Griffin CA, Hruban RH, Morsberger LA, et al. Consistent chromosome abnormalities in adenocarcinoma of the pancreas. Cancer Res 1995;55:2394-9.
12. Boschman CR, Stryker S, Reddy JK, et al. Expression of p53 protein in precursor lesions and adenocarcinoma of human pancreas. Am J Pathol 1994;145:1291-5.
13. Redston MS, Caldas C, Seymour AB, et al. p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions. Cancer Res 1994;54:3025-33.
14. Barton CM, Staddon SL, Hughes CM, et al. Abnormalities of the p53 tumor suppressor gene in human pancreatic cancer. Br J Cancer 1991;64:1076-82.
15. Biankin AV, Kench JG, Morey AL, et al. Overexpression of p21(WAF1/CIP1) is an early event in the development of pancreatic intraepithelial neoplasia. Cancer Res 2001;61:8830-7.
16. Caldas C, Hahn SA, da Costa LT, et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet 1994;8:27-32.
17. Goldstein AM, Fraser MC, Struewing JP, et al. Increased risk of pancreatic cancer in melanoma-prone kindreds with p16INK4 mutations. N Engl J Med 1995;333:970-4.
18. Wilentz RE, Iacobuzio-Donahue CA, et al. Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: Evidence that DPC4 inactivation occurs late in neoplastic progression. Cancer Res 2000;60:2002-6.
19. Hahn SA, Schutte M, Hoque AT, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 1996;271:350-3.
20. Luttges J, Galehdari H, Brocker V, et al. Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis. Am J Pathol 2001;158:1677-83.
21. Dillon DA, Johnson CC, Topazian MD, et al. The utility of Ki-ras mutation analysis in the cytologic diagnosis of pancreatobiliary neoplasm. Cancer J 2000;6:294-301.
22. Evans DB, Frazier ML, Charnsangavej C, et al. Molecular diagnosis of exocrine pancreatic cancer using a percutaneous technique. Ann Surg Oncol 1996;3:241-6.
23. Villanueva A, Reyes G, Cuatrecasas M, et al. Diagnostic utility of K-ras mutations in fine-needle aspirates of pancreatic masses. Gastroenterology 1996;110:1587-94.
24. Pellise M, Castells A, Gines A, et al. Clinical usefulness of KRAS mutational analysis in the diagnosis of pancreatic adenocarcinoma by means of endosonography-guided fine-needle aspiration biopsy. Aliment Pharmacol Ther 2003;17:1299-307.
25. Pinto MM, Emanuel JR, Chaturvedi V, et al. Ki-ras mutations and the carcinoembryonic antigen level in fine needle aspirates of the pancreas. Acta Cytol 1997;41:427-34.
26. Tada M, Komatsu Y, Kawabe T, et al. Quantitative analysis of K-ras gene mutation in pancreatic tissue obtained by endoscopic ultrasonography-guided fine needle aspiration: Clinical utility for diagnosis of pancreatic tumor. Am J Gastroenterol 2002;97:2263-70.
27. McCarthy DM, Maitra A, Argani P, et al. Novel markers of pancreatic adenocarcinoma in fine-needle aspiration: Mesothelin and prostate stem cell antigen labeling increases accuracy in cytologically borderline cases. Appl Immunohistochem Mol Morphol 2003;11:238-43.
28. van Heek T, Rader AE, Offerhaus GJ, et al. K-ras, p53, and DPC4 (MAD4) alterations in fine-needle aspirates of the pancreas: A molecular panel correlates with and supplements cytologic diagnosis. Am J Clin Pathol 2002;117:755-65.
29. Tascilar M, Offerhaus GJ, Altink R, et al. Immunohistochemical labeling for the Dpc4 gene product is a specific marker for adenocarcinoma in biopsy specimens of the pancreas and bile duct. Am J Clin Pathol 2001;116:831-7.
30. Khalid A, Pal R, Sasatomi E, et al. Use of microsatellite marker loss of heterozygosity in accurate diagnosis of pancreaticobiliary malignancy from brush cytology samples. Gut 2004;53:1860-5.
31. Khalid A, Finkelstein SD, Zahid M, et al. The role of pancreatic cyst aspirate DNA analysis in predicting cyst pathology. Clin Gastroenterol Hepatol 2005;3:967-73.
32. Uchida K, Okazaki K, Konishi Y, et al. Clinical analysis of autoimmune-related pancreatitis. Am J Gastroenterol 2000;95:2788-94.
33. Okazaki K, Chiba T. Autoimmune related pancreatitis. Gut 2002;51:1-4.
34. Horiuchi A, Kawa S, Hamano H, et al. ERCP features in 27 patients with autoimmune pancreatitis. Gastrointest Endosc 2002;55:494-9.
35. Kamisawa T, Egawa N, Nakajima H, et al. Clinical difficulties in the differentiation of autoimmune pancreatitis and pancreatic carcinoma. Am J Gastroenterol 2003;98:2694-9.
36. Hamano H, Kawa S, Horiuchi A, et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med 2001;344:732-8.
37. Pearson RK, Longnecker DS, Chari ST, et al. Controversies in clinical pancreatology: Autoimmune pancreatitis: Does it exist? Pancreas 2003;27:1-13.
38. Rosch T, Lorenz R, Braig C, et al. Endoscopic ultrasound in pancreatic tumor diagnosis. Gastrointest Endosc 1991;37:347-52.
39. Baron PL, Aabakken LE, Cole DJ, et al. Differentiation of benign from malignant pancreatic masses by endoscopic ultrasound. Ann Surg Oncol 1997;4:639-43.
40. Glasbrenner B, Schwarz M, Pauls S, et al. Prospective comparison of endoscopic ultrasound and endoscopic retrograde cholangiopancreatography in the preoperative assessment of masses in the pancreatic head. Dig Surg 2000;17:468-74.
41. Khalid A, Whitcomb DC. The importance of autoimmune pancreatitis. Gastroenterology 2001;121:1518-20.