Bim-dependent apoptosis follows IGFBP-5 down-regulation in neuroblastoma cells

Biochemical and Biophysical Research Communications

Volumn 351, Issue 2, 2006, Pages 547-552

  Tanno, Barbara ^a   Vitali, Roberta ^a   Arcangelis, Davide De ^a   Mancini, Camillo ^a   Eleuteri, Patrizia ^a   Dominici, Carlo ^b,c,d   Raschellà, Giuseppe ^a  

^a ENEA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^d UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Apoptosis; Bim; IGF axis; IGFBP 5; Neuroblastoma

Indexed keywords

BIM PROTEIN; CASPASE 9; CYTOCHROME C; MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN BAX; SMALL INTERFERING RNA; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 5;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; GENE SILENCING; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; UPREGULATION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5; MEMBRANE PROTEINS; MITOCHONDRIA; NEUROBLASTOMA; PROTO-ONCOGENE PROTEINS;

EID: 33750506305     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.10.062     Document Type: Article

References (23)

1. Liu J.P., Baker J., Perkins A.S., Robertson E.J., and Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75 (1993) 59-72
2. Baserga R., Peruzzi F., and Reiss K. The IGF-1 receptor in cancer biology. Int. J. Cancer 107 (2003) 873-877
3. Pollak M.N., Schernhammer E.S., and Hankinson S.E. Insulin-like growth factors and neoplasia. Nat. Rev. Cancer 4 (2004) 505-518
4. Baxter R.C. Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities. Am. J. Physiol. Endocrinol. Metab. 278 (2000) E967-E976
5. Nam T.J., Busby Jr. W.H., Rees C., and Clemmons D.R. Thrombospondin and osteopontin bind to insulin-like growth factor (IGF)-binding protein-5 leading to an alteration in IGF-I-stimulated cell growth. Endocrinology 141 (2000) 1100-1106
6. Butt A.J., Dickson K.A., McDougall F., and Baxter R.C. Insulin-like growth factor-binding protein-5 inhibits the growth of human breast cancer cells in vitro and in vivo. J. Biol. Chem. 278 (2003) 29676-29685
7. Miyakoshi N., Richman C., Kasukawa Y., Linkhart T.A., Baylink D.J., and Mohan S. Evidence that IGF-binding protein-5 functions as a growth factor. J. Clin. Invest 107 (2001) 73-81
8. Tanno B., Cesi V., Vitali R., Sesti F., Giuffrida M.L., Mancini C., Calabretta B., and Raschella G. Silencing of endogenous IGFBP-5 by micro RNA interference affects proliferation, apoptosis and differentiation of neuroblastoma cells. Cell Death Differ. 12 (2005) 213-223
9. Brodeur G.M. Neuroblastoma: biological insights into a clinical enigma. Nat. Rev. Cancer 3 (2003) 203-216
10. el Badry O.M., Helman L.J., Chatten J., Steinberg S.M., Evans A.E., and Israel M.A. Insulin-like growth factor II-mediated proliferation of human neuroblastoma. J. Clin. Invest. 87 (1991) 648-657
11. Lovat P.E., Di Sano F., Corazzari M., Fazi B., Donnorso R.P., Pearson A.D., Hall A.G., Redfern C.P., and Piacentini M. Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide. J. Natl. Cancer Inst. 96 (2004) 1288-1299
12. Melino G., Bernassola F., Ranalli M., Yee K., Zong W.X., Corazzari M., Knight R.A., Green D.R., Thompson C., and Vousden K.H. p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J. Biol. Chem. 279 (2004) 8076-8083
13. Adrain C., and Martin S.J. The mitochondrial apoptosome: a killer unleashed by the cytochrome seas. Trends Biochem. Sci. 26 (2001) 390-397
14. Walton J.D., Kattan D.R., Thomas S.K., Spengler B.A., Guo H.F., Biedler J.L., Cheung N.K., and Ross R.A. Characteristics of stem cells from human neuroblastoma cell lines and in tumors. Neoplasia 6 (2004) 838-845
15. Green D.R. Apoptotic pathways: ten minutes to dead. Cell 121 (2005) 671-674
16. Zhao Y., Tan J., Zhuang L., Jiang X., Liu E.T., and Yu Q. Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim. Proc. Natl. Acad. Sci. USA 102 (2005) 16090-16095
17. Dijkers P.F., Birkenkamp K.U., Lam E.W., Thomas N.S., Lammers J.W., Koenderman L., and Coffer P.J. FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J. Cell Biol. 156 (2002) 531-542
18. Ley R., Ewings K.E., Hadfield K., Howes E., Balmanno K., and Cook S.J. Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover. J. Biol. Chem. 279 (2004) 8837-8847
19. Tan T.T., Degenhardt K., Nelson D.A., Beaudoin B., Nieves-Neira W., Bouillet P., Villunger A., Adams J.M., and White E. Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy. Cancer Cell 7 (2005) 227-238
20. Yin P., Xu Q., and Duan C. Paradoxical actions of endogenous and exogenous insulin-like growth factor-binding protein-5 revealed by RNA interference analysis. J. Biol. Chem. 279 (2004) 32660-32666
21. James P.L., Stewart C.E., and Rotwein P. Insulin-like growth factor binding protein-5 modulates muscle differentiation through an insulin-like growth factor-dependent mechanism. J. Cell Biol. 133 (1996) 683-693
22. Butt A.J., Dickson K.A., Jambazov S., and Baxter R.C. Enhancement of tumor necrosis factor-alpha-induced growth inhibition by insulin-like growth factor-binding protein-5 (IGFBP-5), but not IGFBP-3 in human breast cancer cells. Endocrinology 146 (2005) 3113-3122
23. Tanno B., Negroni A., Vitali R., Pirozzoli M.C., Cesi V., Mancini C., Calabretta B., and Raschella G. Expression of insulin-like growth factor-binding protein 5 in neuroblastoma cells is regulated at the transcriptional level by c-Myb and B-Myb via direct and indirect mechanisms. J. Biol. Chem. 277 (2002) 23172-23180