Exposure to altered gravity during specific developmental periods differentially affects growth, development, the cerebellum and motor functions in male and female rats

Advances in Space Research

Volumn 38, Issue 6, 2006, Pages 1138-1147

  Nguon, K ^a   Ladd, B ^a   Sajdel Sulkowska, E M ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cerebellum; Developmental vulnerability; Hypergravity; Motor functions; Rat

Indexed keywords

ENVIRONMENTAL IMPACT; GROWTH KINETICS; LIVING SYSTEMS STUDIES; NEUROLOGY; SPACE RESEARCH;

CEREBELLUM; DEVELOPMENTAL VULNERABILITY; HYPERGRAVITY; MOTOR FUNCTIONS; RATS;

GRAVITATION;

EID: 33750503804     PISSN: 02731177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.asr.2006.09.007     Document Type: Article

References (38)

1. Aizikov G.S., and Markin A.S. Postures, movements and equilibrium functions of rats after flights on biosatellites. Kosm. Biol. Aviakosm. Med. 15 (1981) 33-38
2. Altman J., and Bayer S.A. Development of Cerebellum (1997), CRC Press, Inc., Boca Raton, FL
3. Andersen S.L. Trajectories of brain development: point of vulnerability or window of opportunity?. Neurosci. Behav. Res. 27 (2003) 3-18
4. Anken R.H., Kappel T., and Rahmann H. Morphometry of fish inner ear otoliths after development at 3 G hypergravity. Acta Otolaryngol. 118 (1998) 534-539
5. Anken R.H., Werner K., and Rahmann H. Effects of hypergravity on the development of cell number and asymmetry in fish brain nuclei. Adv. Space Res. 30 (2002) 849-853
6. Auvray N., Caston J., Reber A., and Stelz T. Role of the cerebellum in the ontogenesis of the equilibrium behavior in the young rat: a behavioral study. Brain Res. 505 (1989) 291-301
7. Bouet V., Ijkema-Paassen J., Wubbels R., and Gramsbergen A. Development of the locomotor system in 2 G exposed rats. J. Gravit. Physiol. 11 (2004) 165-166
8. Bouet V., Wubbels R.J., de Jong H.A., and Gramsbergen A. Behavioural consequences of hypergravity in developing rats. Brain Res. Dev. Brain Res. 153 (2004) 69-78
9. Brocard F., Clarac F., and Vinay L. Gravity influences the development of inputs from the brain to lumbar motorneurons in the rat. Neuroreport 14 (2003) 1697-1700
10. Bruce L.L., and Fritzsch B. The development of vestibular connections in rat embryos in microgravity. J. Gravt. Physiol. 4 (1997) 59-62
11. Caston J., Lalonde R., Delhaye-Bouchaud N., and Mariani J. The cerebellum and the postural sensimotor learning in mice and rats. Behav. Brain res. 95 (1998) 17-22
12. Dobbing J., and Sands J. Comparative aspects of the brain growth spurt. Early Hum. Dev. 3 (1979) 79-83
13. Gaboyard S., Sans A., and Lehouelleur J. Differential impact of hypergravity on maturating innervations in vestibular epithelia during rat development. Brain Res. Dev. Brain res. 143 (2003) 15-23
14. Gimenez y Ribotta M., Sandillon F., and Privat A. Influence of hypergravity on the development of monoaminergic system in the rat spinal cord. Brain Res. Dev. Brain Res. 111 (1998) 147-157
15. Heaton M.B., Mitchell J.J., and paiva M. Ethanol-induced alterations in neurotrophin expression in developing cerebellum: relationship to periods of temporal susceptibility. Alcohol. Clin. Exp. Res. 23 (1999) 1637-1642
16. Katafuchi T., Hori T., Oomura Y., and Koizumi K. Cerebellar affernts to neuroendocrine cell: implications for adaptive responses to stimulated weightlessness. Endocrine J. 42 (1995) 729-737
17. Ladd, B., Nguon, K., Sajdel-Sulkowska, E.M. Exposure to hypergravity affects pregnant rat dams and pregnancy outcome. Adv. Space Res., doi:10.1016/j.asr.2005.049, 2005.
18. Laputin A.N., and Kadenyuk L.K. Change-over coordination structure of astronauts' voluntary movements during orbital flight conditions. J. Gravit. Physiol. 6 (1999) 121-122
19. Layne C.S., McDonald P.V., and Bloomberg J.J. Neuromascular activation patterns during treadmill walking after space flight. Exp. Brain Res. 113 (1997) 104-116
20. Newberg A.B. Changes in the central nervous system and their clinical correlates during long-term spaceflight. Aviat. Space Environ. Med. 65 (1994) 562-572
21. Nguon K., Li G.-H., and Sajdel-Sulkowska E.M. CNS development under altered gravity: Cerebellar glial and neuronal protein expression in rat neonates exposed to hypergravity. Adv. Space Res. 33 (2004) 1375-1380
22. Nguon K., Baxter M.G., and Saidel-Sulkowska E.M. Perinatal exposure to polychlorinated biphenyls differentially affects cerebellar development and motor functions in male and female neonates. Cerebellum 4 (2005) 112-122
23. Nguon, K., Ladd, B., Sajdel-Sulkowska, E.M. Development of motor coordination and cerebellar structure in male and female rat neonates exposed to hypergravity. Adv. Space Res., doi:10.1016/j.asr.2005.02.095, 2005b.
24. Pierce D.R., Willams D.K., and Light K.E. Purkinje cell vulnerability to developmental ethanol exposure in the rat cerebellum. Alcohol. Clin. Exp. Res. 23 (1999) 1650-1659
25. Reschke M.F., Bloomberg J.J., Harm D.L., et al. Posture, locomotion, spatial orientation, and motion sickness as function of space flight. Brain Res. Brain Res. Rev. 28 (1998) 102-107
26. Sajdel-Sulkowska E.M., Li G.H., Ronca A.E., et al. Effects of hypergravity exposure on the developing central nervous system: possible involvement of thyroid hormone. Exp. Biol. Med. 226 (2001) 790-798
27. Sajdel-Sulkowska E.M., Nguon K., Rosen G., and Baxter M.G. Purkinje cell loss and motor impairment in rats developing under hypergravity. Neuroreport 16 (2005) 2037-2040
28. Savel'ev S.V., Serova L.V., Besova N.V., et al. Effect of weightlessness on rat's endocrine system development. Aviakosm. Ekolog. Med. 32 (1998) 31-36
29. Schmitz C., Dafotakis M., Heinsen H., et al. Use of cryostat sections from snap-frozen nervous tissue for combining stereological estimates with histological, cellular and molecular analyses on adjacent sections. J. Chem. Neuroanat. 20 (2000) 21-29
30. Sebastian C.E., Pfau K., and Horn E.R. An age-dependent sensitivity of the roll-induced vestibuloocular reflex to hypergravity exposure of several days in an amphibian (Xenopus laevis). Acta Astronaut. 42 (1998) 419-430
31. Serova L.V., Denisova L.A., and Pustynnikova A.M. Comparative analysis of hypo- and hypergravity effects on prenatal development of mammals. Physiologist 28 (1985) s5-s8
32. Sondag H.N., de Jong H.A., and Oosterveld W.J. Altered behavior in hamsters conceived and born in hypergravity. Brain res. Bull. 43 (1997) 289-294
33. Sulkowski G.M., Li G.-H., and Sajdel-Sulkowska E.M. CNS development under altered gravity: CD15, NCAM and GFAP expression in rat neonates exposed to hypergravity. Adv. Space Res. 33 (2004) 1423-1430
34. Tafforin C. Relationship between orientation, movement and posture in weightlessness: preliminary ethological observations. Acta Astronaut. 21 (1990) 271-280
35. Thullier F., Hayzoun K., Dubois M., Lestienne F., and Lalonde R. Exploration and motor activity in juvenile and adult rats exposed to hypergravity at 1.8 G during development: a preliminary report. Physiol. Behav. 76 (2002) 617-622
36. Tran T.D., and Kelly S.J. Critical periods for ethanol-induced cell loss in the hippocampal formation. Neurotoxicol. Teratol. 25 (2003) 519-528
37. Woodall S.M., Johnson B.M., Breier B.H., and Gluckman P.D. Chronic maternal undernutrition in the rat leads to delayed postnatal growth and elevated blood pressure of offspring. Pediatr. Res. 40 (1996) 438-443
38. Yates B.J., Holmes M.J., and Jian B.J. Plastic changes in processing of graviceptive signals during spaceflight potentially contribute to postflight orthostaticin tolerance. J. Vest. Res. 13 (2003) 395-404