CNS development under altered gravity: Cerebellar glial and neuronal protein expression in rat neonates exposed to hypergravity

Advances in Space Research

Volumn 33, Issue 8, 2004, Pages 1375-1380

  Nguon, K ^a   Li, G H ^a   Sajdel Sulkowska, E M ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Cerebellum; Development; Hypergravity; Rat

Indexed keywords

BONE; CELLS; DATA REDUCTION; GRAVITATION; MOLECULAR BIOLOGY; NEUROLOGY; PROTEINS;

CENTRAL NERVOUS SYSTEM (CNS); CEREBELLAR GLIAL;

SPACE RESEARCH;

GRAVITY; NERVOUS SYSTEM;

EID: 2342478621     PISSN: 02731177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.asr.2003.06.016     Document Type: Article

References (27)

1. Bruce L.L. Fritzsch B. The development of vestibular connections in rat embryos in microgravity J. Grav. Physiol. 4 1997 59-62
2. D'Amelio F. Daunton N.G. Effects of spaceflight in the adductor longus muscle of rats flown in the Soviet Biosatsllite COSMOS 2044, A study employing neural cell adhesion molecule (N-CAM) immunocytochemistry and conventional morphological techniques (light and electron microscopy) J. Neuropathol. Exp. Neural. 51 1992 415-431
3. Day J.R. Frank A.T. O'Callaghan J.P., et-al. Effects of microgravity and bone morphogenic protein II on GFAP in rat brain J. Appl. Physiol. 85 1998 716-722
4. Gustave Dit Duflo S. Gestreau C. Lacour M. Fos expression in the rat brain after exposure to gravito-inertial force change Brain Res. 861 2000 333-344
5. Holstein G.R. Kukielka E. Martinelli G.P. Anatomical observations of the rat cerebella nodules after 24 h of spaceflight J. Grav. Physiol. 1999 6, 47-50
6. Katafuchi T.T. Hori Y. Oomura, et-al. Cerebellar afferents to neuroendocrine cells: Implications for adaptive responses to simulated weightlessness Endocr. J. 42 1995 729-737
7. Keefe J.R. Alberts J.R. Krasnov I.E., et-al. Developmental morphology of the eye, vestibular system and brain in day fetal and newborn rats exposed in utero to null gravity during the flight of Cosmos NASA Tech. Mem. 88223 1986
8. Malacinski G.M. Neff A.W. Alberts J.R., et-al. Developmental biology in outer space BioScience 39 1989 314-320
9. Matsumoto-Miyai K. Ninomiya A. Yamasaki H., et-al. NMDA-dependent proteolysis of presynaptic adhesion molecule L1 in the hippocampus by neuropsin J. Neurosci. 23 2003 7727-7736
10. Newberg A.B. Changes in the central nervous system and their clinical correlates during long-term spaceflight Aviat. Space Environ. Med. 65 1994 562-572
11. Nicholas A.P. King J.L. Sambandam T., et-al. Immunohistochemical localization of citrullinated proteins in adult rat brain J. Comp. Neural. 459 2003 251-266
12. Noetzel M.J. Synthesis and phosphorylation of the glial fibrillary acidic protein during brain development: a tissue slice study Glia 3 1990 450-457
13. Paulus U. Kortje K.H. Rahmann H. Effect of development and altered gravity conditions on cytochrome oxidase activity in a vestibular nucleus of the larval teleost brain: A quantitative electromicroscopical study J. Neurobiol. 24 1993 1131-1141
14. Pompeiano O. d'Ascanio P. Centini C., et-al. Immediate early gene expression in the vestibular nuclei and related vegetative areas in rats during space flight Acta Otolaryngol. Suppl. 545 2001 120-126
15. Rahmann H. Slenzka K. Kortje K.H., et-al. Synaptic plasticity and gravity: Ultrastractural, biochemical and physico-chemical fundamentals Adv. Space Res. 12 1992 63-72
16. Rahmann H. Anken R.H. Gravity related research with fishes-perspectives in regard to upcoming International Space Station, ISS Adv. Space Res. 30 2002 697-710
17. Richoilley G. Planel H. Gasset G. Effects of hypergravity on Paramecium tetraurelia C. R. Acad. Sci. III 316 1993 585-587
18. Sajdel-Sulkowska E.M. Li G.-H. Ronca A.E., et-al. Effects of hypergravity exposure on the developing central nervous system: Possible involvement of thyroid hormone Exp. Biol. Med. 226 2001 790-798
19. Savel'ev S.V. Serova L.V. Besova N.V., et-al. Effect of weightlessness on rats endocrine system development Aviakosm. Ekolog. Med. 32 1998 31-36
20. Serova L.V. Hypergravity and development of mammals Physiologist 34 1991 s135-s136
21. Slenzka K. Appel R. Rahmann H. Developmental and altered gravity dependent changes in glucose-6-phospate dehydrogenase activity in the brain of the cichlid fish Oreochromis mossambicus Neurochem. Int. 26 1995 579-585
22. Slenzka K. Appel R. Kappel T., et-al. Influence of altered gravity on brain cellular energy and plasma membrane metabolism of developing lower aquatic vertebrates Adv. Space Res. 17 1996 125-128
23. Slenzka K. Appel R. Rahmann H. Metabolic adaptation to long term changes in gravity environment Adv. Space Res. 1998 22, 273-276
24. Sulkowski, G.M., Li, G.-H., Sajdel-Sulkowska, E.M. Effect of environmental impacts on the developing CNS: CD15, NCAM-L1 and GFAP expression in rat neonates exposed to hypergravity. Adv. Space Res. (in press)
25. Thelen K. Kedar V. Panicker A.K., et-al. The neuronal cell adhesion molecule L1 potentiates integrin-dependent cell migration to extracellular matrix proteins J. Neurosci. 22 2002 4818-4931
26. Uno Y. Horii A. Umemoto M., et-al. Effects of hypergravity on morphology and osteopontin expression in the rat otolith organs J. Vestib. Res. 10 2000 283-289
27. Wubbels R.J. de Jong H.A.A. Vestibular-induced behaviour of rats born and raised in hypergravity Brain Res. Bull. 52 2000 349-356