Down-regulation of cellular vascular endothelial growth factor levels induces differentiation of leukemic cells to functional leukemic-dendritic cells in acute myeloid leukemia

Leukemia and Lymphoma

Volumn 47, Issue 10, 2006, Pages 2224-2233

  Kang, Hyun Kyu ^a,b   Park, Jung Sun ^a,b   Kim, Sang Ki ^a,b   Choi, Bo Hwa ^a,b   Pham, Than Nhan Nguyen ^a,b   Zhu, Xiao Wei ^a,b   Cho, Duck ^b   Nam, Jong Hee ^b   Kim, Young Jin ^b   Rhee, Joon Haeng ^b   Chung, Ik Joo ^a,b   Kim, Hyeoung Joon ^a   Lee, Je Jung ^a,b  

^a Chonnam National University Medical School   (South Korea)

^b Chonnam National University   (South Korea)

Author keywords

Dendritic cell; Leukemia; VEGF

Indexed keywords

INTERLEUKIN 12; NEUTRALIZING ANTIBODY; VASCULOTROPIN;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL STIMULATION; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE LOCATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; MALE; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; CELL DIFFERENTIATION; CELL SEPARATION; DENDRITIC CELLS; DOWN-REGULATION; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEUKEMIA; MALE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES, CYTOTOXIC; TIME FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33750484687     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.1080/10428190600732236     Document Type: Article

References (32)

1. Lowenberg, B and Downing, J and Burnett, A. (1999) Acute myeloid leukemia N Engl J Med, 341, pp. 1051-1062.
2. Burnett, A and Kell, J and Rowntree, C. (2000) Acute myeloid leukemia: therapeutic indications Curr Opin Hematol, 7, pp. 333-338.
3. Buzyn, A and Petit, F and Ostankovitch, M and Figueiredo, S and Varet, B and Guillet, J and (1999) Membrane-bound Fas (Apo-1/CD95) ligand on leukemic cells: A mechanism of tumor immune escape in leukemia patients Blood, 94, pp. 3135-3140.
4. Buggins, A and Lea, N and Gaken, J and Darling, D and Farzaneh, F and Mufti, G and (1999) Effect of costimulation and the microenvironment on antigen presentation by leukemic cells Blood, 94, pp. 3479-3490.
5. Hirano, N and Takahashi, T and Takahashi, T and Ohtake, S and Hirashima, K and Emi, N and (1996) Expression of costimulatory molecules in human leukemias Leukemia, 10, pp. 1168-1176.
6. Notter, M and Willinger, T and Erben, U and Thiel, E. (2001) Targeting of a B7-1 (CD80) immunoglobulin G fusion protein to acute myeloid leukemia blasts increases their costimulatory activity for autologous remission T cells Blood, 97, pp. 3138-3145.
7. Reid, D. (2001) Dendritic cells and immunotherapy for malignant disease Br J Haematol, 112, pp. 874-887.
8. Banchereau, J and Steinman, R. (1998) Dendritic cells and the control of immunity Nature, 392, pp. 245-252.
9. Hart, D. (1997) Dendritic cells: Unique leukocyte populations which control the primary immune response Blood, 90, pp. 3245-3287.
10. Harrison, B and Adams, J and Briggs, M and Brereton, M and Yin, J. (2001) Stimulation of autologous proliferative and cytotoxic T-cell responses by 'leukemic dendritic cells' derived from blast cells in acute myeloid leukemia Blood, 97, pp. 2764-2771.
11. Choudhury, B and Liang, J and Thomas, E and Flores-Romo, L and Xie, Q and Agusala, K and (1999) Dendritic cells derived in vitro from acute myelogenous leukemia cells stimulate autologous, antileukemic T-cell responses Blood, 93, pp. 780-786.
12. Koski, G and Schwartz, G and Weng, D and Gress, R and Engels, F and Tsokos, M and (1999) Calcium ionophore-treated myeloid cells acquire many dendritic cell characteristics independent of prior differentiation state, transformation status, or sensitivity to biologic agents Blood, 94, pp. 1359-1371.
13. Waclavicek, M and Berer, A and Oehler, L and Stock, J and Schloegl, E and Majdic, O and (2001) Calcium ionophore: A single reagent for the differentiation of primary human acute myelogenous leukaemia cells towards dendritic cells Br J Haematol, 114, pp. 466-473.
14. Westers, T and Stam, A and Scheper, R and Regelink, J and Nieuwint, A and Schuurhuis, G and (2003) Rapid generation of antigen-presenting cells from leukaemic blasts in acute myeloid leukaemia Cancer Immunol Immunother, 52, pp. 523-524.
15. Fiedler, W and Graeven, U and Ergun, S and Verago, S and Kilic, N and Stock-schlader, M and (1997) Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia Blood, 89, pp. 1870-1875.
16. Folkman, J. (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease Nat Med, 1, pp. 27-31.
17. Lee, J and Chung, I and Park, M and Ryang, D and Park, C and Kim, H. (2001) Increased angiogenesis and Fas-ligand expression are independent processes in acute myeloid leukemia Leuk Res, 25, pp. 1067-1073.
18. Gabrilovich, D and Ishida, T and Nadaf, S and Ohm, J and Carbone, D. (1999) Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function Clin Cancer Res, 5, pp. 2963-2970.
19. Gabrilovich, D and Ishida, T and Oyama, T and Ran, S and Kravtsov, V and Nadaf, S and (1998) Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo Blood, 92, pp. 4150-4166.
20. Ohm, J and Shurin, M and Esche, C and Lotze, M and Carbone, D and Gabrilovich, D. (1999) Effect of vascular endothelial growth factor and FLT3 ligand on dendritic cell generation in vivo J Immunol, 163, pp. 3260-3268.
21. Almand, B and Resser, J and Lindman, B and Nadaf, S and Clark, J and Kwon, E and (2000) Clinical significance of defective dendritic cell differentiation in cancer Clin Cancer Res, 6, pp. 1755-1766.
22. Lee, J and Takei, M and Hori, S and Inoue, Y and Harada, Y and Tanosaki, R and (2002) The role of PGE(2) in the differentiation of dendritic cells: How do dendritic cells influence T-cell polarization and chemokine receptor expression? Stem Cells, 20, pp. 448-459.
23. Lee, J and Nam, C and Nam, J and Lee, H and Chung, I and Park, M and (2004) Generation of cytotoxic donor CD8+ T cells against relapsing leukemic cells following allogeneic transplantation by stimulation with leukemic cell- or leukemic lysate pulsed donor cell-derived dendritic cells Leuk Res, 28, pp. 517-524.
24. McCutcheon, M and Wehner, N and Wensky, A and Kushner, M and Doan, S and Hsiao, L and (1997) A sensitive ELISPOT assay to detect low-frequency human T lymphocytes J Immunol Methods, 210, pp. 149-166.
25. Choudhury, A and Gajewski, J and Liang, J and Popat, U and Claxton, D and Fliche, K and (1997) Use of leukemic dendritic cells for the generation of antileukemic cellular cytotoxicity against Philadelphia chromosome-positive chronic myelogenous leukemia Blood, 89, pp. 1133-1142.
26. Bae, Y and Yi, H and Lee, H and Jo, E and Kim, J and Lee, T and (2003) Differential activation of formyl peptide receptor-like 1 by peptide ligands J Immunol, 171, pp. 6807-6813.
27. Lee, J and Choi, B and Nam, J and Park, M and Song, W and Yang, D and (2004) The generation of leukemic dendritic cells from acute myeloid leukemia cells is potentiated by the addition of CD40 l at the terminal maturation stage J Clin Apher, 19, pp. 130-136.
28. Marten, A and Renoth, S and Lilienfeld-Toal, M and Buttgereit, P and Schakowski, F and Glasmacher, A and (2001) Enhanced lytic activity of cytokine-induced killer cells against multiple myeloma cells after co-culture with idiotype-pulsed dendritic cells Haematologica, 86, pp. 1029-1037.
29. Le, Y and Gong, W and Li, B and Dunlop, N and Shen, W and Su, S and (1999) Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and formyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation J Immunol, 163, pp. 6777-6784.
30. Hussong, J and Rodgers, G and Shami, P. (2000) Evidence of increased angiogenesis in patients with acute myeloid leukemia Blood, 95, pp. 309-313.
31. Lee, J and Kook, H and Park, M and Nam, J and Choi, B and Song, W and (2004) Immunotherapyusing autologous monocyte-derived dendritic cells pulsed with leukemic cell lysates for acute myeloid leukemia relapse after autologous peripheral blood stem cell transplantation J Clin Apher, 19, pp. 66-70.
32. Galea-Lauri, J. (2002) Immunological weapons against acute myeloid leukaemia Immunology, 107, pp. 20-27.