Detrimental effect of eicosapentaenoic acid supplementation on bone following ovariectomy in rats

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 75, Issue 6, 2006, Pages 419-427

  Poulsen, Raewyn C ^a   Kruger, Marlena C ^a  

^a MASSEY UNIVERSITY   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIFEDIOL; FATTY ACID; ICOSAPENTAENOIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BONE DENSITY; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG MEGADOSE; FATTY ACID BLOOD LEVEL; FEMALE; LOW DRUG DOSE; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RAT; VITAMIN BLOOD LEVEL;

ANIMALS; BODY WEIGHT; BONE AND BONES; BONE DENSITY; CHOLECALCIFEROL; EICOSAPENTAENOIC ACID; FEMALE; LIPIDS; ORGAN SIZE; OVARIECTOMY; RATS; UTERUS;

ANIMALIA;

EID: 33750458990     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.plefa.2006.08.003     Document Type: Article

References (26)

1. Kruger M., and Horrobin D. Calcium metabolism, osteoporosis and essential fatty acids. A review. Progr. Lipid Res. 36 2/3 (1997) 131-151
2. Kruger M., Coetzer H., de Winter R., Gericke G., and van Papendorp D. Calcium, gamma-linolenic acid and eicosapentaenoic acid supplementation in senile osteoporosis. Aging, Clin. Exp. Res. 10 5 (1998) 385-394
3. van Papendorp D., Coetzer H., and Kruger M.C. Biochemical profile of osteoporotic patients on essential fatty acid supplementation. Nutr. Res. 15 3 (1995) 325-334
4. Schlemmer C., Coetzer H., Claassen N., and Kruger M. Oestrogen and essential fatty acid supplementation corrects bone loss due to ovariectomy in the female Sprague-Dawley rat. Prostaglandins Leukot. Essent. Fatty Acids 61 6 (1999) 381-390
5. Kruger M., Claassen N., Smuts C., and Potgieter H. Correlation between essential fatty acids and parameters of bone formation and degradation. Asia Pacific J. Clin. Nutr. 64 4 (1997) 235-238
6. Kruger M., Claassen N., Schlemmer C., and Coetzer H. Essential fatty acid supplementation: effect on oestrogen deficiency induced bone loss in the female rat. Calc. Tissue Int. 64 Suppl 1 (1999) 63
7. Sakaguchi K., Morita I., and Murota S. Eicosapentaenoic acid inhibits bone loss due to ovariectomy in rats. Prostaglandins Leukot. Essent. Fatty Acids 50 (1994) 81-84
8. National Research Council. Nutrient Requirements of Laboratory Animals, Fourth Revised Edition (1995), National Academy Press, Washington, DC
9. James K., Butts C., Hardacre A., Koolard J., Clark S., and Scott M. The effect of drying room temperature on the nutritional quality of New Zealand-grown maize for growing rats. J. Sci. Food Agric. 84 (2004) 147-157
10. O'Loughlin P.D., and Morris H.A. Oophorectomy acutely increases calcium excretion in adult rats. J. Nutr. 133 7 (2003) 2277-2280
11. Baggio B., Budakovic A., Nassuato M.A., Vezzoli G., Manzato E., Luisetto G., and Zaninotto M. Plasma phospholipid arachidonic acid content and calcium metabolism in idiopathic calcium nephrolithiasis. Kidney Int. 58 3 (2000) 1278-1284
12. Raisz L.G., Pilbeam C.C., and Fall P.M. Prostaglandins-mechanisms of action and regulation of production in bone. Osteoporosis Int. 3 (1993) S136-S140
13. Raisz L.G., Alander C., and Simmons H. Effects of prostaglandin E3 and eicosapentaenoic acid on rat bone in organ culture. Prostaglandins 37 5 (1989) 615-625
14. Achard F., Gilbert M., Benistant C., Ben Slama S., DeWitt D.L., Smith W.L., and Lagarde M. Eicosapentaenoic and docosahexaenoic acids reduce PGH synthase 1 expression in bovine aortic endothelial cells. Biochem. Biophys. Res. Commun. 241 2 (1997) 513-518
15. Kris-Etherton P.M., Harris W., and Appel L. Fish consumption, fish oil, omega-3 fatty acids and cardiovascular disease. Circulation 106 (2002) 2747-2757
16. Shibutani Y., Kurokawa M., Inoue K., Hamada Y., and Yajima G. Toxicity studies of 5,8,11,14,17-eicosapentaenoic acid ethyl ester (EPA-E) (III*) chronic toxicity study in rats. Yakuhin Kenkyu 20 4 (1989) 826-844
17. Shibutani Y., Ishikawa T., and Othtsuka Y. Toxicity studies of 5,8,11,14,17-eicosapentaenoic acid ethyl ester (EPA_E) (I) acute toxicity study in rats. Yakuhin Kenkyu 20 4 (1989) 801-807
18. Shibutani Y., Kurokawa M., Inoue K., Hamada Y., and Yajima G. Toxicity studies of 5,8,11,14,17-eicosapentaenoic acid ethyl ester (EPA-E) (II*) subacute toxicity study in rats. Yakuhin Kenkyu 20 4 (1989) 808-825
19. Horrobin D.F., Fokkema M., and Mukiet F. The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihommogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism. Prostaglandins Leukot. Essent. Fatty Acids 68 (2003) 301-304
20. Judex S., Wohl G., Wolff R., Leng W., Gillis A., and Zernicke R. Dietary fish oil supplementation adversely affects cortical bone morphology and biomechanics in growing rabbits. Calcif. Tissue Int. 66 6 (2000) 443-448
21. Saito J., Terano T., Hirai A., Shiina T., Tamura Y., and Saito Y. Mechanisms of enhanced production of PGI(2) in cultured rat vascular smooth muscle cells enriched with eicosapentaenoic acid. Atherosclerosis 131 2 (1997) 219-228
22. Lu C., Chan S., Haughey N., Lee W., and Mattson M. Selective and biphasic effect of the membrane lipid peroxidation product 4-hydroxy-2,3-nonenal on N-methyl-d-aspartate channels. J. Neurochem. 78 3 (2001) 577-589
23. Xu K., Zweier J., and Becker L. Hydroxyl radical inhibits sarcoplasmic reticulum Ca2+-ATPase function by direct attack on the ATP binding site. Circ. Res. 80 1 (1997) 76-81
24. Watkins B., Reinwald S., Li Y., and Seifert M.F. Protective actions of soy isoflavones and n-3 PUFAs on bone mass in ovariectomised rats. J. Nutr. Biochem. 16 (2005) 479-488
25. G. Fernandes, A. Bhattacharya, D. Sun, K. Zaman, R. Lawrence, A. Krishnan, Inhibition of bone loss by n-3 fatty acids in 12 month-old OVX mice as an animal model for menopause. In: Translating the Genome: 2003; Experimental Biology Abstract # 3964, San Diego, California, 2003.
26. Li Y., Reinwald S., Seifert M., and Watkins B. Dietary docosahexaenoic acid supplementation maintains bone mass in ovariectomised rats. Exp. Biol. Abstr. (2003) B321